Corticosteron, a Crystallized Compound with the Biological Activity of the Adrenal-cortical Hormone

Fremery, P. De; Laqueur, Ernst; Reichstein, T.; Spanhoff, R. W.; Uyldert, Ina E.

doi:10.1038/139026a0

Cited by 45 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…-Comparative assays on desoxycorticosterone and cortin in adrenalectomized rats by the muscular fatigue method show that the former is inactive by mouth, but is active when sub cutaneously administered and that it possesses some progesterone action. "Cortin" is active by mouth in adrenal insufficiency but does not exhibit progesterone activity (101). In adrenalectomized dogs kept on a low sodium and chloride diet, the daily injection of 1 to 1.5 mg. desoxycorticosterone, dissolved in oil, maintains a 10 kg.…”

Section: Suprarenal Cortexmentioning

confidence: 99%

Hormones

Koch¹

1940

Annu. Rev. Biochem.

View full text Add to dashboard Cite

Because the more definitely biochemical advances in the field of hormones are very nearly limited to those of the steroid type together with the limited space available for reviewing a very extensive litera ture, I have taken advantage of the editors' liberal policy and have limited this review to the biochemistry of the steroid hormones. ESTROGENSDistribution and forms of estrogens.-Although all of the estro gen activity in cow and hog ovaries is considered to be in the free form, only 50 to 75 per cent is free in the horse ovary or its follicular fluid (1). During pregnancy 50 to 75 per cent of the blood estrogens in women are in the free form (2). The best method of hydrolysis of the conjugated forms of estrogens in pregnancy urine is still a prob lem. One g.roup recommends boiling the pregnancy urine for ten minutes with 15 per cent concentrated hydrochloric added. Longer heating results in serious loss of estrogens (3). Others recommend that the urine from pregnant mares be allowed to stand at pH 0.4 to 0.6 at room temperature for at least four weeks (4). The writer, in studies on urine from normal men and nonpregnant women, has obtained the highest yield of estrogens by boiling the urine previously acidified to pH 1 to 1.2 with hydrochloric acid for fifteen minutes.Longer boiling at this pH also causes destruction of estrogens. The gradual increase in the urinary excretion of estrogens in women to a peak of 80,000 rat units near the termination has been confirmed, but in one case of toxemia of pregnancy, the excretion was subnormal.

show abstract

Section: Suprarenal Cortexmentioning

confidence: 99%

Hormones

Koch¹

1940

Annu. Rev. Biochem.

View full text Add to dashboard Cite

show abstract

“…The first compound isolated from the adrenal gland which had significant cortin activity was named corticosterone by Reichstein (18,19). Other cortin-active constituents were later named according to their structural relation to corticosterone, namely, dehydrocorticosterone, 17-hydroxycorticosterone, 17-hydroxydehydrocorticosterone and desoxycorticosterone.…”

Section: Nomenclaturementioning

confidence: 99%

“…be active in a series of four animals in both curative and preventive experiments (19), 0.25 to 0.5 mg. of corticostorone being equivalent in potency to the extract from 50 gm. of glands.…”

Section: The Adrenalectomized Dogmentioning

confidence: 99%

The Adrenal Cortical Hormones

Pfiffner

1942

Advances in Enzymology - And Related Areas of Molecular Biology

View full text Add to dashboard Cite

“…In the case of the progestational properties of cortical hormone it has been shown that desoxycorticosterone acetate produces a progesta¬ tional reaction in the uterus of the rabbit in doses of 5-10 mg. (i.e. 5 to 10 times as much as the required amount of progesterone) [Miescher, Fischer & Tschopp, 1938;de Fremery & Spanhoff, 1939;Robson, 1939;Heuverswyn, Collins, Williams, & Gardner, 1939], and in the cat [Leathern & Crafts, 1940]. Like progesterone, desoxycorticosterone is also able (a) to maintain pregnancy in spayed mice and in spayed and hypophysectomized rabbits, (b) to suppress the response of the rabbit uterus to pituitrin, (c) to suppress the oestrous cycle in mice and (d) to inhibit the effects of oestrone [Robson, 1939].…”

mentioning

confidence: 99%

The Effect of Desoxycorticosterone on the Endometrium of Monkeys

Zuckerman¹

1940

Journal of Endocrinology

View full text Add to dashboard Cite

The fact that the properties of progesterone and desoxycorticosterone overlap is indicated on the one hand by experiments which show that progesterone produces some of the specific effects of desoxycorticosterone and on the other by experiments which demonstrate that desoxycorticosterone has a progestational effect on the endometrium. In the first case it has been shown : (a) that progesterone prolongs the life of adrenalectomized animals [

show abstract

Corticosteron, a Crystallized Compound with the Biological Activity of the Adrenal-cortical Hormone

Cited by 45 publications

References 5 publications

Hormones

Hormones

The Adrenal Cortical Hormones

The Effect of Desoxycorticosterone on the Endometrium of Monkeys

Contact Info

Product

Resources

About