Corticosterone mediates electroacupuncture-produced anti-edema in a rat model of inflammation

Li, Aihui; Zhang, Rui-Xin; Wang, Yi; Zhang, Haiqing; Ren, Ke; Berman, Brian M.; Tan, Ming; Lao, Lixing

doi:10.1016/j.dza.2008.01.024

Cited by 6 publications

(15 citation statements)

References 21 publications

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“…The SNS also activates the HPA axis, stimulating cortisol release [150,152]. As previous mentioned, corticosterone inhibits cytokines, prostaglandin and cox-2, thereby blocking inflammation in rats [151].…”

Section: The Role Of the Endocannabinoid System In Dry Needling-mediamentioning

confidence: 95%

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Peripheral and Spinal Mechanisms of Pain and Dry Needling Mediated Analgesia: A Clinical Resource Guide for Health Care Professionals

Butts¹,

Dunning²

2016

Int J Phys Med Rehabil

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There are a number of biochemical, biomechanical, endocrinological and neurovascular mechanisms underpinning the anti-nociceptive and anti-inflammatory effects of dry needling (DN). While myofascial trigger points likely play a role in peripheral pain, a diagnostic tool for localizing them has not been validated, and DN studies that have targeted trigger points to elicit localized twitch responses have reported mixed results. Therefore, the mechanism responsible for DN-mediated analgesia may be more complicated. DN activates opioid-based pain reduction, mediated by endogenous cannabinoids and the sympathetic nervous system, and non-opioid pain relief via serotonin and norepinephrine from the brain stem. DN also triggers the hypothalamic-pituitary-adrenal axis centrally and the corticotropin releasing hormone-proopiomelanocortin-corticosteroid axis locally to inhibit cox-2, reducing inflammatory cytokines. Recent studies demonstrate that DN combined with mechanical and/or electrical stimulation may reverse PKC-mediated peripheral hyperalgesic priming by normalizing nociceptive channels, to include TRPV, ASIC, TTX and P2X/Y. Electrical DN (EDN) stimulates immune cells, fibroblasts and keratinocytes to release CGRP and substance-P, altering the stimulation of TTX receptors to reverse hyperalgesia. It also encourages the supraoptic nucleus to release oxytocin to quiet ASIC receptors peripherally and stimulate opioid interneurons spinally. Moreover, EDN inhibits ERK1/2 kinase pathways of inflammation in the spinal cord and stimulates Aδ fibers and N/OFQ to reverse C-fiber mediated central changes. Mechanotransduction of fibroblasts and peripheral nerves via TRPV1 and P2X/Y-mediated intracellular Ca 2+ wave propagation and subsequent activation of the nucleus accumbens inhibits spinal pain transmission via glycinergic and opioidergic interneurons. The increased ATP is metabolized to adenosine, which activates P1 purinergic receptors, events considered key to DN analgesia and rho kinase-based tissue remodeling. Mechanotransduction-mediated release of histamine further explains analgesia secondary to needling points distal to pain. DN-mediated analgesia is dependent on a number of synergistic physiologic events involving biochemical and mechanical processes in neural, connective and muscle tissue.

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Section: The Role Of the Endocannabinoid System In Dry Needling-mediamentioning

confidence: 95%

“…Following an injection of CFA, EDN was able to control the resulting edema by stimulating a 10-fold increase in corticosterone. When corticosterone receptors were chemically blocked, however, the anti-inflammatory effects of DN were lost [152].…”

Section: Stimulation Of the Neuroendocrine System Via Dry Needlingmentioning

confidence: 99%

Peripheral and Spinal Mechanisms of Pain and Dry Needling Mediated Analgesia: A Clinical Resource Guide for Health Care Professionals

Butts¹,

Dunning²

2016

Int J Phys Med Rehabil

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“…Accumulative evidence demonstrates that EA significantly inhibits paw inflammation and hyperalgesia in a rat model [12–14]. However, it has been reported that EA may produce differential effects under healthy and pathological conditions [15].…”

Section: Introductionmentioning

confidence: 99%

Effect of Electroacupuncture on Activation of p38MAPK in Spinal Dorsal Horn in Rats with Complete Freund's Adjuvant-Induced Inflammatory Pain

Liang

Fang

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Activation of mitogen-activated protein kinases (MAPKs), especially p38 MAPK, plays an important role in the development of central sensitization related to persistent inflammatory pain. Electroacupuncture (EA) is well known to relieve persistent inflammatory pain. However, little is known about relationship between EA and p38 MAPK. Inflammatory pain rat model was induced by intraplantar injection of complete Freund's adjuvant (CFA). Male adult SD rats were randomly divided into the saline group, CFA group, and CFA + EA group. EA (constant saquare wave, 2 Hz and 100 Hz alternating frequencies, intensities ranging from 1 to 2 mA) was applied to bilateral “Zusanli” (ST 36) and “Kunlun” acupoints (BL 60) for 30 min, once per day. The paw edema and paw withdrawal threshold (PWT) were measured at preinjection and days postinjection 1, 3, and 14. Spinal p-p38MAPK- immunoreactivty (p-p38MAPK-IR) cells were detected by immunohistochemistry at postinjection day 3 and 14. EA significantly inhibited paw edema at postinjection days 14 and increased PWT at postinjection days 3 and 14. Moreover, the increasing number of spinal p-p38MAPK-IR cells which was induced by CFA injection was suppressed by EA stimulation. These results indicate that anti-inflammatory and analgesic effect of EA might be associated with its inhibition of spinal p38 MAPK activation and thereby provide a potential mechanism for the treatment of inflammatory pain by EA.

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“…This antiedema effect was eradicated in animals given an adrenalectomy (ADX) and in those pretreated with a corticosterone antagonist RU486, 34,35 but neither treatment blocked the antihyperalgesia effect of EA. (2) At the pituitary level, EA significantly increased plasma adrenocorticotropic hormone (ACTH) levels, while the ACTH receptor antagonist ACTH (1124) blocked EA antiedema but not EA antihyperalgesia (unpublished data).…”

Section: The Hormonal Pathwaymentioning

confidence: 99%

“…34,35 Pharmacologic studies showed that EA antihyperalgesia is mediated by mu and delta but not kappa opioid receptors. 36 Studies also show that lesioning of the G-protein-coupled receptor by pertussis toxin blocks EA antihyperalgesia.…”

Section: The Neural Pathwaymentioning

confidence: 99%

The Status and Future of Acupuncture Mechanism Research

Napadow

Ahn

Longhurst

et al. 2008

The Journal of Alternative and Complementary Medicine

Self Cite

188

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On November 8-9, 2007, the Society for Acupuncture Research (SAR) hosted an international conference to mark the tenth anniversary of the landmark NIH [National Institutes of Health] Consensus Development Conference on Acupuncture. More than 300 acupuncture researchers, practitioners, students, funding agency personnel, and health policy analysts from 20 countries attended the SAR meeting held at the University of Maryland School of Medicine, Baltimore, MD. This paper summarizes important invited lectures in the area of basic and translational acupuncture research. Specific areas include the scientific assessment of acupuncture points and meridians, the neural mechanisms of cardiovascular regulation by acupuncture, mechanisms for electroacupuncture applied to persistent inflammation and pain, basic and translational research on acupuncture in gynecologic applications, the application of functional neuroimaging to acupuncture research with specific application to carpal-tunnel syndrome and fibromyalgia, and the association of the connective tissue system to acupuncture research. In summary, mechanistic models for acupuncture effects that have been investigated experimentally have focused on the effects of acupuncture needle stimulation on the nervous system, muscles, and connective tissue. These mechanistic models are not mutually exclusive. Iterative testing, expanding, and perhaps merging of such models will potentially lead to an incremental understanding of the effects of manual and electrical stimulation of acupuncture needles that is solidly rooted in physiology. 861

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Corticosterone mediates electroacupuncture-produced anti-edema in a rat model of inflammation

Abstract: Background: Electroacupuncture (EA) has been reported to produce anti-edema and antihyperalgesia effects on inflammatory disease. However, the mechanisms are not clear. The present study investigated the biochemical mechanisms of EA anti-inflammation in a rat model.

Cited by 6 publications

References 21 publications

Peripheral and Spinal Mechanisms of Pain and Dry Needling Mediated Analgesia: A Clinical Resource Guide for Health Care Professionals

Peripheral and Spinal Mechanisms of Pain and Dry Needling Mediated Analgesia: A Clinical Resource Guide for Health Care Professionals

Effect of Electroacupuncture on Activation of p38MAPK in Spinal Dorsal Horn in Rats with Complete Freund's Adjuvant-Induced Inflammatory Pain

The Status and Future of Acupuncture Mechanism Research

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