Corticosterone metabolism by chicken follicle cells does not affect ovarian reproductive hormone synthesis in vitro

Rettenbacher, Sophie; Henriksen, Rie; Groothuids, Ton G.; Lepschy, Michael

doi:10.1016/j.ygcen.2012.12.013

Cited by 9 publications

(8 citation statements)

References 56 publications

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“…At the age of 23 days, chickens showed two factors. One included HDL and 17-OHP, the other one comprises progesterone and cortisol (see Table 2), which agrees with the data of S. Rettenbacher et al [29]. These authors showed that an increase in the glucocorticoid content due to stress or exogenous experimental impact (for example, glucocorticoid administration to intact chickens) can lead to a decrease in the conversion of progesterone to 17-OHP and its derivatives due to inhibition of specific enzymes (e.g.…”

Section: Factor Analysis With Principal Component Methods Of Blood Biosupporting

confidence: 88%

“…At the same time, in incubated in vitro ovarian tissues of female chickens and testicles of males (i.e. without exogenous stress impact), glucocorticoids do not interfere with the progesterone transformation into 17-OHP and then into androstenedione, testosterone and other steroid products [29]. It was shown [30] that stress inhibits the enzyme responsible for the conversion of cholesterol to pregnenolone.…”

Section: Factor Analysis With Principal Component Methods Of Blood Biomentioning

confidence: 98%

“…These authors showed that an increase in the glucocorticoid content due to stress or exogenous experimental impact (for example, glucocorticoid administration to intact chickens) can lead to a decrease in the conversion of progesterone to 17-OHP and its derivatives due to inhibition of specific enzymes (e.g. 17-hydroxylase, 17,20-lyase, 17p-hydroxysteroid dehydrogenase) or competitive interaction of glucocorticoids with nuclear and membrane progesterone receptors involved in regulation of expression of the glucocorticoid-synthesizing enzymes [29]. At the same time, in incubated in vitro ovarian tissues of female chickens and testicles of males (i.e.…”

Section: Factor Analysis With Principal Component Methods Of Blood Biomentioning

confidence: 99%

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Involvement of Cholesterol, Progesterone, Cortisol and Lipoproteins in Metabolic Changes During Early Ontogenesis of Broiler Chicks of an Industrial Cross

Kolesnik¹,

Дерхо²

2017

S-h. biol.

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Morphophysiological changes in body are influenced by environmental factors, what is more, the specific nature of the body reactions depends on the reaction rate and the stage of ontogenesis on which the physiological stimuli act (I. Schmalhausen, 1982). Also it is known that hormones participate in the regulation of metabolism, growth and development, in adaptation processes. We determined the concentration of high-density (HDL) and low density (LDL) lipoproteins directly involved in protein and lipid metabolism, total cholesterol (TCS), progesterone (P 4), 17hydroxyprogesterone (17-OHP), and cortisol in blood plasma of Hubbard F15 broiler chickens at early postnatal ontogenesis using four groups of poultry of the industrial herd of Chebarkulskaya Ptitsa LLC (Chelyabinsk Province, Russian Federation), 10 animals in each, aged 1, 7, 23 and 42 days, respectively. The role and interrelations of these substances in metabolism were assessed using Pearson's correlation analysis and factor analysis by the principal components method with Varimax factor rotation. Thus, in 1-day aged chicks, the integration of factors HDL, LDL, TCS, P 4 and cortisol involved in metabolic processes and metabolism regulations was noted with r-Pearson for P 4

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Section: Factor Analysis With Principal Component Methods Of Blood Biosupporting

confidence: 88%

Section: Factor Analysis With Principal Component Methods Of Blood Biomentioning

confidence: 98%

Section: Factor Analysis With Principal Component Methods Of Blood Biomentioning

confidence: 99%

See 1 more Smart Citation

Involvement of Cholesterol, Progesterone, Cortisol and Lipoproteins in Metabolic Changes During Early Ontogenesis of Broiler Chicks of an Industrial Cross

Kolesnik¹,

Дерхо²

2017

S-h. biol.

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“…Though this determination is outside the scope of the present study, we outline two nonmutually exclusive hypotheses to help direct future research. First, females could reduce the accumulation of circulating plasma corticosterone in yolks during vitellogenesis through catalysis at follicles via enzymes such as 11β-HSD (Rettenbacher et al, 2013;Yang, 1997). Second, during vitellogensis and nesting, females may have a hypo-reactive HPA axis (Jessop et al, 2000, Jessop, 2001Paitz et al, 2014;Valverde et al, 1999), reducing the amount of circulating steroid available for accumulation in the yolk.…”

Section: Discussionmentioning

confidence: 99%

Evidence of embryonic regulation of maternally derived yolk corticosterone

Carter

Bowden

Paitz

2018

Journal of Experimental Biology

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In recent years, the potential for maternal stress effects to adaptively alter offspring phenotype has received considerable attention. This research has identified offspring traits that are labile in response to maternal stress; however, an understanding of the mechanisms underlying these effects is lagging and is crucial to appreciating the significance of this maternal effect. In the present study, we sought to better understand maternal stress effects by examining the potential for embryonic regulation of corticosterone exposure, determining the phenotypic consequences of elevated corticosterone during development, and characterizing the levels of maternally transferred corticosterone in unmanipulated eggs using Trachemys scripta. By dosing eggs with tritiated corticosterone and tracking the steroid throughout development, we found that most corticosterone is metabolized, and less than 1% of the corticosterone dose reaches the embryo as free corticosterone. We also found that exogenous dosing of corticosterone, in concentrations sufficient to overwhelm embryonic metabolism, reduces embryonic survival and negatively impacts hatchling traits important to fitness. Our results demonstrate that concentrations of maternal corticosterone in the yolks of unmanipulated eggs are low and are significantly lower than the doses of corticosterone required to elicit phenotypic effects in hatchlings. Taken together, these results provide evidence that both the embryo and the female may minimize corticosterone accumulation in the embryo to avoid reductions in embryonic survival and negative impacts on offspring phenotype and fitness.

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“…We extracted steroids from egg yolk according to Rettenbacher, Henriksen, Groothuids, and Lepschy (2013). Briefly, we homogenized three egg yolks, and 5 g was mixed with 10 mL of double-distilled water and stirred for 30 min.…”

Section: High-performance Liquid Chromatography Analysismentioning

confidence: 99%

Distribution and concentration of maternal progesterone in the yolk of Greater Rhea eggs (Rhea americana)

et al. 2017

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Progesterone is the most concentrated maternal yolk steroid characterized to date in birds; however, no information about it is available in ratite eggs. We collected freshly laid eggs from zoo-housed Greater Rhea females (Rhea americana) bred under similar rearing conditions during two breeding seasons to characterize concentration and distribution of maternal yolk progesterone. After high-performance liquid chromatography analysis, yolk hormone was measured using a commercial electrochemiluminescence immunoassay. Progesterone concentrations were found to vary significantly among the yolk layers, supporting a follicular origin for this steroid in Greater Rhea eggs. Additionally, highly similar mean absolute yolk progesterone concentrations were detected between 2013 and 2015 breeding seasons (1,332.98 ± 82.59 and 1,313.59 ± 85.19 ng/g, respectively). These values are also comparable to those found in some domestic carinate species. Findings suggest that at population level, when rearing conditions are similar, mean absolute yolk maternal progesterone concentrations also appear bounded. Future research on the factors and mechanisms that regulate progesterone deposition in Greater Rhea eggs is needed to better understand whether its levels depend on different rearing conditions.

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Corticosterone metabolism by chicken follicle cells does not affect ovarian reproductive hormone synthesis in vitro

Cited by 9 publications

References 56 publications

Involvement of Cholesterol, Progesterone, Cortisol and Lipoproteins in Metabolic Changes During Early Ontogenesis of Broiler Chicks of an Industrial Cross

Involvement of Cholesterol, Progesterone, Cortisol and Lipoproteins in Metabolic Changes During Early Ontogenesis of Broiler Chicks of an Industrial Cross

Evidence of embryonic regulation of maternally derived yolk corticosterone

Distribution and concentration of maternal progesterone in the yolk of Greater Rhea eggs (Rhea americana)

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