1984
DOI: 10.1111/j.1365-2265.1984.tb00061.x
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Corticotrophin Releasing Factor: Responses in Normal Subjects and Patients With Disorders of the Hypothalamus and Pituitary

Abstract: Synthetic CRF-41 has been given to 43 patients with hypothalamic, pituitary or adrenal diseases and contrasted with the responses in 20 normal subjects. In the normal subjects the mean increment in serum cortisol (+/- SE) was 276 +/- 38 nmol/l; the increments showed a significant negative correlation with the basal serum cortisol levels (r = -0.56; P less than 0.02). The mean peak serum cortisol was 662 +/- 34 nmol/l and the mean peak corticosterone was 28.6 +/- 3.8 nmol/l. There was a significant positive cor… Show more

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Cited by 153 publications
(59 citation statements)
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“…Since there are significant negative correlations between the basal and percent maximum increase in plasma cortisol levels after CRH in patients with Cushings disease, the weakened ACTH response to hCRH can be explained by a high basal cortisol concentration, as in normal subjects. In patients with Nelson's syndrome and Addison's disease, elevated basal ACTH levels increased further after CRH administration, and these data are compatible with the observations reported previously using oCRF (Muller et al, 1982;Fujita et al, 1984;Lytras et al, 1984;Hirata et al, 1984). Low ACTH levels in patients with adrenal Cushing's syndrome or isolated ACTH deficiency did not respond to hCRH at all.…”
supporting
confidence: 89%
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“…Since there are significant negative correlations between the basal and percent maximum increase in plasma cortisol levels after CRH in patients with Cushings disease, the weakened ACTH response to hCRH can be explained by a high basal cortisol concentration, as in normal subjects. In patients with Nelson's syndrome and Addison's disease, elevated basal ACTH levels increased further after CRH administration, and these data are compatible with the observations reported previously using oCRF (Muller et al, 1982;Fujita et al, 1984;Lytras et al, 1984;Hirata et al, 1984). Low ACTH levels in patients with adrenal Cushing's syndrome or isolated ACTH deficiency did not respond to hCRH at all.…”
supporting
confidence: 89%
“…Since the isolation of ovine corticotropinreleasing factor (oCRF), a peptide with 41 aminoacid residues (Vale et al, 1981), there have been a number of studies to assess the clinical usefulness of synthetic oCRF in patients with various disorders (Orth et al, 1982;Nakahara et al, 1983;Pieters et al, 1983;Tsukada et al, 1984;Schulte et al, 1984;Fujita et al, 1984;Tomita et al, 1984;Kageyama et al, 1984 ;Lytras et al, 1984 ;Hermus et al, 1985). In 1983, Shibahara et al demonstrated that the amino acid sequence of human corticotropin-releasing hormone (hCRH) is identical with that of rat CRF (Rivier et al, 1983) and different at seven amino acid residues from that of oCRF.…”
mentioning
confidence: 99%
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“…In contrast, a study of 43 patients with hypothalamic, pituitary or adrenal disease found that six patients who were ACTH deficient in response to insulin-induced hypoglycaemia responded normally to CRF-41 (ovine CRH) [86]. However, these patients had suffered either hypothalamic or pituitary lesions and the data suggested a functional defect of ACTH secretion due to the failure of CRF to reach the corticotroph.…”
Section: Crh Testingmentioning
confidence: 95%
“…Em radioimunoensaios convencionais, o valor de dosagem de ACTH utilizado para essa distinção é de 10 ng/L (118)(119)(120) . Confirmado o hipercortisolismo ACTH dependente, a avaliação hipofisária com ressonância magnética de hipófise é realizada.…”
Section: Corticotropinomasunclassified