“…Since the isolation of ovine corticotropinreleasing factor (oCRF), a peptide with 41 aminoacid residues (Vale et al, 1981), there have been a number of studies to assess the clinical usefulness of synthetic oCRF in patients with various disorders (Orth et al, 1982;Nakahara et al, 1983;Pieters et al, 1983;Tsukada et al, 1984;Schulte et al, 1984;Fujita et al, 1984;Tomita et al, 1984;Kageyama et al, 1984 ;Lytras et al, 1984 ;Hermus et al, 1985). In 1983, Shibahara et al demonstrated that the amino acid sequence of human corticotropin-releasing hormone (hCRH) is identical with that of rat CRF (Rivier et al, 1983) and different at seven amino acid residues from that of oCRF.…”