Corticotrophins, Corticosteroids, and Prostaglandins

Corticotrophins, corticosteroids, and prostaglandins

“…The mechanism of action of ACTH seizures is still unclear but direct stimulation of ACTH receptors on the brain and adrenal glands are correlated with its action. The use of (ACTH) has been reported to have adverse effects on cardiac function, nervous system, and mild rash ( Brophy & Ray, 2015 [R]; Watson et al, 2019 [R]). The meta-analysis of 19 studies reviewing the use of ACTH reported edema as one of the most commonly reported adverse event followed by insomnia, mood swings, and hyper- glycemia ( Kittanamongkolchai et al, 2016 ) [M].…”

“…This is useful for conditions in which the whole body is in need of corticosteroids, however, is associated with significant systemic toxicities in many isolated conditions that are treated with corticosteroid. Many of these toxicities are well known hyperglycemia, hormonal axis depression, and immunosuppression whereas some long-term effects such as hypertension, and behavioral/cognitive changes has also been reported ( Brophy & Ray, 2015 [R]; Kaplan & Brophy, 2017 [R]). Some of these effects are dose dependent and most of them wear off once the patient is off medication.…”