2014
DOI: 10.1371/journal.pone.0088109
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Corticotropin-Releasing Factor Facilitates Epileptiform Activity in the Entorhinal Cortex: Roles of CRF2 Receptors and PKA Pathway

Abstract: Whereas corticotropin-releasing factor (CRF) has been considered as the most potent epileptogenic neuropeptide in the brain, its action site and underlying mechanisms in epilepsy have not been determined. Here, we found that the entorhinal cortex (EC) expresses high level of CRF and CRF2 receptors without expression of CRF1 receptors. Bath application of CRF concentration-dependently increased the frequency of picrotoxin (PTX)-induced epileptiform activity recorded from layer III of the EC in entorhinal slices… Show more

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Cited by 7 publications
(5 citation statements)
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“…On the other hand, Gi signaling inhibits adenylate cyclase, thereby decreasing cAMP production and PKA activation . Again, in good agreement with protective mechanisms driving P2Y expression, elevated cAMP has been reported to be proepileptogenic and PKA inhibition reduced epileptiform activity …”
Section: Discussionsupporting
confidence: 58%
“…On the other hand, Gi signaling inhibits adenylate cyclase, thereby decreasing cAMP production and PKA activation . Again, in good agreement with protective mechanisms driving P2Y expression, elevated cAMP has been reported to be proepileptogenic and PKA inhibition reduced epileptiform activity …”
Section: Discussionsupporting
confidence: 58%
“…Because the EC is an important structure involved in epilepsy, we studied the roles of NOP in epilepsy by bath perfusion of PTX or Mg 2+ -free extracellular solution in entorhinal slices. As demonstrated previously (Kurada et al, 2014;Wang et al, 2013), stable epileptiform activity could be recorded from layer III of the EC in the horizontal slices after perfusion of PTX (100 μM) for ~20 min. After recordings of stable basal epileptiform activity for 10 min, NOP (0.3 μM) dissolved in the PTX-containing extracellular solution was applied to the slices for ~ 7 min.…”
Section: Activation Of Orl-1 Receptors Depresses Epileptic Activity Isupporting
confidence: 69%
“…CRF exerts its physiological function by binding to its G-protein coupled receptors, CRF 1 and CRF 2 , to activate the downstream cAMP signaling [ 31 , 45 ]. CRF 1 receptors are highly expressed in the pituitary and the limbic areas where they modulate the activity of HPA axis [ 46 ].…”
Section: Endocrine System and Depressionmentioning
confidence: 99%