Cortisol and dehydroepiandrosterone-sulphate levels correlate with symptom severity in first-episode psychosis

Garner, Belinda; Phassouliotis, Christina; Phillips, Lisa; Markulev, Connie; Butselaar, Felicity; Bendall, Sarah; Yao, Yun; McGorry, Patrick D.

doi:10.1016/j.jpsychires.2010.06.008

Cited by 64 publications

(50 citation statements)

References 49 publications

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“…5 Although studies have suggested that basal cortisol levels are elevated in first-episode psychosis (FEP), reactivity to acute stress is also impaired. [6][7][8] A third biological pathway in psychosis is related to the influence of glucocorticoids on neuroplasticity. 1 Increased concentrations of cortisol have been shown to reduce neurotrophin levels (such as brain derived neurotrophic factor, BDNF), which can lead to volumetric changes in the brain (e.g., reduced hippocampal volume).…”

Section: Introductionmentioning

confidence: 99%

Hair cortisol in drug-naïve first-episode individuals with psychosis

Andrade

Rizzo

Noto

et al. 2016

Rev. Bras. Psiquiatr.

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Objectives: To compare hair cortisol concentrations (HCC) in drug-naïve first-episode psychosis (FEP) patients and healthy controls and to investigate the correlations between HCC and psychopathology. Methods: Twenty-four drug-naïve FEP patients and 27 gender-and age-matched healthy control subjects were recruited. The Structured Clinical Interview for DSM-IV (SCID-1) was used to confirm/ rule out diagnoses, and the Positive and Negative Symptoms Scale (PANSS) was used to assess symptom severity. Hair samples (2-3 cm long) obtained from the posterior vertex region of the scalp were processed in 1-cm segments considering a hair growth rate of 1 cm per month. The 1-cm segments were classified according to their proximity to the scalp: segment A was the closest to the scalp and referred to the month prior to inclusion in the study. Segments B and C referred to the 2nd and 3rd months prior to the time of evaluation respectively. Hair steroid extraction was performed using a known protocol. Results: Two-way analysis of covariance (ANCOVA) with gender and age as covariates revealed a group effect (F 1.106 = 4.899, p = 0.029) on HCC. Between-segment differences correlated with total PANSS score and with PANSS General Psychopathology subscale and total score. Conclusions: Our findings suggest that hypothalamic-pituitary-adrenal (HPA) axis, as assessed by long-term (3-month) cortisol concentration, is abnormal in the early stages of psychosis. The magnitude of changes in HCC over time prior to the FEP correlates to psychopathology. HPA axis abnormalities might begin prior to full-blown clinical presentation requiring hospital admission.

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Section: Introductionmentioning

confidence: 99%

Hair cortisol in drug-naïve first-episode individuals with psychosis

Andrade

Rizzo

Noto

et al. 2016

Rev. Bras. Psiquiatr.

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“…On the other hand, studies employing psychosocial challenge paradigms have reported blunted cortisol responses in schizophrenia patients [5,6]. Individuals who are at risk for developing psychosis [7,8], those with first episode psychosis [9,10], and those *Address correspondence to this author at the Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan; Tel: +81 42 341 2711; Fax +81 42 346 1744; E-mail: hori@ncnp.go.jp with schizotypal personality [11,12] have also been shown to be associated with altered HPA axis function, although findings are again not uniform, that is, both hyper-and hypocortisolism are reported. All these findings indicate that although schizophrenia would be associated with altered HPA axis function, its precise nature is yet to be established.…”

Section: Introductionmentioning

confidence: 99%

Elevated Cortisol Level and Cortisol/DHEAS Ratio in Schizophrenia as Revealed by Low-Dose Dexamethasone Suppression Test

Hori¹

2012

TONEUROPPJ

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Abstract:Earlier studies have used the dexamethasone (DEX) suppression test (DST) to investigate the hypothalamicpituitary-adrenal (HPA) function in schizophrenia, although the findings are controversial. Recently there has been an increased interest in the role of dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) in HPA axis function. Several studies have investigated basal DHEA(S) levels and cortisol/DHEA(S) ratios in schizophrenia patients, while no attempts have been made to investigate DHEA(S) level in response to the DEX administration. We aimed to compare the post-DEX cortisol and DHEAS levels and the cortisol/DHEAS ratio between schizophrenia patients and healthy controls. Here we administered the DST to 43 patients with schizophrenia and 37 age-and sex-matched healthy controls. Plasma cortisol levels, serum DHEAS levels, and cortisol/DHEAS ratio after administration of 0.5 mg of DEX were compared between the two groups. Schizophrenia patients showed significantly higher cortisol level and cortisol/DHEAS ratio than controls, while DHEAS levels were not significantly different between groups. These results suggest that besides the cortisol level, cortisol/DHEAS ratio as assessed with the DST might reflect abnormal HPA axis function in schizophrenia.

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“…Previous studies have suggested that alterations in cortisol and DHEA-S levels may play a role in the pathophysiology of schizophrenia [3,16,[20][21][22][23]. Serum cortisol and DHEA-S levels may be used as a biological marker for the diagnosis of schizophrenia; however, further studies with larger sample sizes are warranted to support this finding [3].…”

Section: Introductionmentioning

confidence: 94%

Serum Cortisol and DHEA-S Levels in Schizophrenic Patients with Different Response to Antipsychotic Therapy: Association with Psychopathology / Серумски Концентрации На Кортизол И DHEA-S Кал Пациенти Со Шизофренша Со Различен Одговор На Антипсихотичната Терапша Асоци.1Аци.1А Со Психопатологшата

Babinkostova

Stefanovski

Janicevic-Ivanovska

et al. 2015

Prilozi

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Background: Previous studies suggested that alterations in serum cortisol and DHEA-S levels may play a role in the pathophysiology of schizophrenia. Imbalance in serum cortisol and DHEA-S levels may be related to responsivity to antipsychotic treatment. Aim: To compare serum cortisol and DHEA-S levels between patients with schizophrenia and healthy controls and to evaluate their association with psychopathology in schizophrenic patients with different response to antipsychotic treatment. Material and Methods:This clinical prospective study included 60 patients with schizophrenia and 40 healthy age and sex matched controls. All patients experienced an acute exacerbation of the illness (PANSS: P1 and P3 ≥ 4). Clinical evaluation of patients was performed using the Positive and Negative Symptom Scale. A questionnaire for socio-demographic and clinical data collection was used. For the purposes of the study, the examined group was divided in two subgroups: responders and nonresponders. Serum cortisol and DHEA-S levels were measuredat baseline in all participants and after 3 and 6 weeks of the antipsychotic treatment in patients with schizophrenia. Results: Patients with schizophrenia had significantly higher serum cortisol and DHEA-S levels comparedwith control group. Responders had significantly higher serum cortisol and DHEA-S levels compared with nonresponders. Responders group had significant correlation between serum cortisol and PANSS positive scale score as well as between hostility and serum DHEA-S. Conclusion: Elevated serum cortisol and DHEA-S levels may play a role in the pathophysiology of schizophrenia. Serum cortisol and DHEA-S are associated with psychopathology in schizophrenic patients with different response to antipsychotic therapy.

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Cortisol and dehydroepiandrosterone-sulphate levels correlate with symptom severity in first-episode psychosis

Cited by 64 publications

References 49 publications

Hair cortisol in drug-naïve first-episode individuals with psychosis

Hair cortisol in drug-naïve first-episode individuals with psychosis

Elevated Cortisol Level and Cortisol/DHEAS Ratio in Schizophrenia as Revealed by Low-Dose Dexamethasone Suppression Test

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