Cortisol and testosterone in hair as biological markers of systolic heart failure

Pereg, David; Chan, Jeff; Russell, Elizabeth M.; Berlin, Tatiana; Mosseri, Morris; Seabrook, Jamie A.; Koren, Gideon; Uum, Stan Van

doi:10.1016/j.psyneuen.2013.07.015

Cited by 49 publications

(28 citation statements)

References 38 publications

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“…As far as we know, the reverse case, that is, an imbalance in favor of the HPA axis, has not to date been discussed in the context of social behavior. However, in the healthcare domain, a high cortisol/testosterone ratio has been reported to predict ischemic heart disease (Smith et al, 2005) and hospitalization related to congestive heart failure (Pereg et al, 2013), generally suggesting that higher cortisol relative to testosterone might be associated with lower cardiovascular health. In sum, further research is needed to answer the question whether it is possible to identify combinations of testosterone and cortisol concentrations which are particularly favorable with regard to prosocial behavior.…”

Section: Discussionmentioning

confidence: 99%

Salivary testosterone and cortisol are jointly related to pro-environmental behavior in men

Sollberger

Bernauer

Ehlert

2015

Social Neuroscience

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Recently, cortisol has been suggested to moderate the positive relationship between testosterone and antisocial behavior. More precisely, high testosterone levels have been found to be related to aggressive or dominant behavior especially when cortisol levels were low. In the present study, we aimed to extend these findings to pro-environmental behavior as an indicator of prosocial behavior. In a first step, 147 male participants provided information on their everyday pro-environmental behavior by completing an online questionnaire on various energy-saving behaviors. In a second step, subjects provided two saliva samples for the assessment of testosterone and cortisol on two subsequent mornings after awakening. We found that testosterone was negatively related to pro-environmental behavior, but only in men with low cortisol. In conclusion, our findings provide first evidence for the joint association of testosterone and cortisol with everyday pro-environmental behavior. These results further reinforce the importance of considering interdependent hormone systems simultaneously rather than focusing on a single hormone.

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Section: Discussionmentioning

confidence: 99%

Salivary testosterone and cortisol are jointly related to pro-environmental behavior in men

Sollberger

Bernauer

Ehlert

2015

Social Neuroscience

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“…However, consistent associations between HCC and stress‐related health outcomes support continued efforts to obtain complementary assessments of such biological markers. Epidemiological studies for HCC examining large samples and including additional instruments addressing emotional reactivity, social desirability, or the individual appraisal, might thus be advantageous .…”

Section: Commentmentioning

confidence: 99%

The Association of Hair Cortisol with Self‐Reported Chronic Psychosocial Stress and Symptoms of Anxiety and Depression in Women Shortly after Delivery

Braig

Grabher

Ntomchukwu

et al. 2015

Paediatric Perinatal Epid

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HCC were not found to correlate with self-reports of chronic stress, anxiety, or depressive symptomatology. Among other things, these findings could reflect problems with questionnaire-based assessments obtained shortly after delivery such as recall bias and/or suggest that associations between cortisol secretion and psychosocial stress are difficult to detect due to, e.g. a strong physiological increase of cortisol in the last trimester.

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“…Long-term cortisol exposure may not only be important in developing an increased cardiovascular disease risk profile, but may also have modulating effects in cardiac disease. This is illustrated by the finding that higher HCC have been associated with worse functional status in heart failure (35), and with worse subjective physical health in structural heart disease (32).…”

Section: Cardiometabolic Statusmentioning

confidence: 99%

Clinical applications of cortisol measurements in hair

Wester

Rossum

2015

European Journal of Endocrinology

175

141

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Cortisol measurements in blood, saliva and urine are frequently used to examine the hypothalamus-pituitary-adrenal (HPA) axis in clinical practice and in research. However, cortisol levels are subject to variations due to acute stress, the diurnal rhythm and pulsatile secretion. Cortisol measurements in body fluids are not always a reflection of long-term cortisol exposure. The analysis of cortisol in scalp hair is a relatively novel method to measure cumulative cortisol exposure over months up to years. Over the past years, hair cortisol concentrations (HCC) have been examined in association with a large number of somatic and mental health conditions. HCC can be used to evaluate disturbances of the HPA axis, including Cushing's syndrome, and to evaluate hydrocortisone treatment. Using HCC, retrospective timelines of cortisol exposure can be created which can be of value in diagnosing cyclic hypercortisolism. HCC have also been shown to increase with psychological stressors, including major life events, as well as physical stressors, such as endurance exercise and shift work. Initial studies show that HCC may be increased in depression, but decreased in general anxiety disorder. In posttraumatic stress disorder, changes in HCC seem to be dependent on the type of traumatic experience and the time since traumatization. Increased hair cortisol is consistently linked to obesity, metabolic syndrome and cardiovascular disease. Potentially, HCC could form a future marker for cardiovascular risk stratification, as well as serve as a treatment target.

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Cortisol and testosterone in hair as biological markers of systolic heart failure

Cited by 49 publications

References 38 publications

Salivary testosterone and cortisol are jointly related to pro-environmental behavior in men

Salivary testosterone and cortisol are jointly related to pro-environmental behavior in men

The Association of Hair Cortisol with Self‐Reported Chronic Psychosocial Stress and Symptoms of Anxiety and Depression in Women Shortly after Delivery

Clinical applications of cortisol measurements in hair

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