Cortisol awakening and stress response, personality and psychiatric profiles in patients with takotsubo cardiomyopathy

Kastaun, Sabrina; Schwarz, Niko; Juenemann, Martin; Yeniguen, Mesut; Nef, Holger; Moellmann, Helge; Hamm, Christian W.; Sammer, Gebhard; Hennig, Juergen; Bachmann, Georg; Gerriets, Tibo

doi:10.1136/heartjnl-2014-305745

Cited by 36 publications

(34 citation statements)

References 30 publications

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“…Our findings do not lend support for maladaptive personality or stress coping characteristics, which might predispose to TTC. These results hereby confirm and enlarge our previous findings that female TTC patients seem not to differ in their personality (and psychiatric) profiles when compared with female NSTEMI patients or cardiachealthy women [4]. Although Hefner and colleagues found TTC patients to use some positive coping strategies less often than healthy controls of a three times as large normative sample [6], they did not detect any differences in comparison with ACS patients and do not support a routine evaluation of stress management in TTC patients [7].…”

supporting

confidence: 93%

“…(4,5) 12.2 ± 3.6 11.6 ± 3.8 11.0 ± 3.1 0.585 0.251 Positive 3 (8,9,10) 17.5 ± 2.3 17.6 ± 2.7 17.3 ± 2.3 0.900 0.714 Positive (2,3,4,5,8,9,10) 14. …”

Section: Fundingmentioning

confidence: 97%

“…However, TTC patients showed a blunted cortisol stress response (CSR) compared with cardiac-healthy controls and high incidences of stressful or traumatic life-events compared with healthy controls and non-ST-segment elevation myocardial infarction (NSTEMI) patients [4].…”

mentioning

confidence: 99%

“…All participants gave written, informed consent and have recently attended our previous study. For extensive information about methodological, clinical and sociodemographic characteristics please refer to this publication [4]. The local ethics committee approved the study.…”

mentioning

confidence: 99%

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Locus of control and stress management strategies in women with takotsubo cardiomyopathy

Kastaun

Gerriets

Yeniguen

et al. 2014

International Journal of Cardiology

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supporting

confidence: 93%

“…(4,5) 12.2 ± 3.6 11.6 ± 3.8 11.0 ± 3.1 0.585 0.251 Positive 3 (8,9,10) 17.5 ± 2.3 17.6 ± 2.7 17.3 ± 2.3 0.900 0.714 Positive (2,3,4,5,8,9,10) 14. …”

Section: Fundingmentioning

confidence: 97%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Locus of control and stress management strategies in women with takotsubo cardiomyopathy

Kastaun

Gerriets

Yeniguen

et al. 2014

International Journal of Cardiology

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“…(Abbate et al 2002;Bardales et al 1996;Colucci et al 2000;Feuerstein and Young 2000;Ma et al 2013;Saraste et al 1997). Stress alters the levels of catecholamine hormones, which play an important role in hypertension (Louis et al 2012), cardiac necrosis, arrhythmia, and apoptosis in cardiomyocytes (Kastaun et al 2014;Schomig et al 1991;Zaugg et al 2000;Zhao et al 2013). Therefore, preventing cardiomyocytes from undergoing apoptosis is an important strategy for the treatment of cardiac diseases.…”

Section: Introductionmentioning

confidence: 99%

HSP70 inhibits stress-induced cardiomyocyte apoptosis by competitively binding to FAF1

Gao¹,

Liu²,

Huang³

et al. 2015

Cell Stress and Chaperones

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Stress-induced cardiomyocyte apoptosis plays an important role in the pathogenesis of a variety of cardiovascular diseases. Our early studies showed that HSP70 effectively inhibited apoptosis, but the underlying mechanism remained unclear. Fas-associated factor 1 (FAF1) is a member of the Fas death-inducing signaling complex (Fas-DISC) that acts upstream of caspase-8. We investigated the interactions among FAF1, HSP70, and FAS in stressed cardiomyocytes to elucidate the protective mechanism of HSP70. FAS and caspase-3/8 activity was higher in cardiomyocytes undergoing stress-induced apoptosis in restraint-stressed rats compared with cardiomyocytes in non-stressed rats, which indicated that the Fas signaling pathway was activated after restraint stress. Geranylgeranylacetone (GGA) induced an increase in HSP70 expression, which reduced stress-induced apoptosis. Additionally, overexpression of HSP70 via transfection with the pEGFP-rHSP70 plasmid attenuated norepinephrine (NE)-induced apoptosis. FAF1 expression increased during stressinduced apoptosis, and overexpression of FAF1 exacerbated NE-induced apoptosis. We also found that HSP70 interacted with FAF1. Overexpression of HSP70 inhibited the binding of FAF1 to FAS in H9C2 cells, which indicated that HSP70 suppressed NE-induced apoptosis by competitively binding to FAF1. An N-terminal deletion mutant of HSP70 (HSP70-△N) was unable to interact with FAF1. After HSP70-△N was transfected into H9C2 cells, the cells were unable to attenuate the NE-induced increases in caspase-8 and apoptosis. These results indicate that the 1-120 sequence of HSP70 binds to FAF1, which alters the interactions between FAS and FAF1 and inhibits the activation of the Fas signaling pathway and apoptosis.

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Effects of late‐night eating of easily—or slowly—digestible meals on sleep, hypothalamo‐pituitary‐adrenal axis, and autonomic nervous system in healthy young males

2021

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Aim of the current study was to assess the effects of the digestibility of late-night high calorie meal on sleep and the activities of the hypothalamo-pituitary-adrenal (HPA) and autonomous nervous system (ANS) in healthy young males. For that purpose, effects of an easily digestible meal (starch + sugar-rich meal, SSR, i.e., dessert) or a slowly digestible meal (protein + fat-rich, PFR, i.e. kebab) were investigated in a crossover design in 16 participants (20-26 year old). They did not eat anything after 07:00 PM on Day 0; had an SSR meal on Day 1 and a PFR meal on Day 2 at 10:00 PM. HPA and ANS activities were measured by cortisol awakening response (CAR) and heart rate variability (HRV), respectively. The participants provided salivary samples for CAR; had a 5-min continuous electrocardiogram recording for HRV; and filled in sleep questionnaires. Late-night eating of SSR and PFR diets increased the area under the curve of CAR (p < 0.05) but did not affect HRV parameters (p > 0.05). PFR meal significantly disturbed sleep (p < 0.05). The data suggests that increased activity of HPA, but not ANS, might be involved in pathophysiology of late-night eating and that this might be due to disturbed sleep if slowly-digestible meal is consumed.

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Cortisol awakening and stress response, personality and psychiatric profiles in patients with takotsubo cardiomyopathy

Cited by 36 publications

References 30 publications

Locus of control and stress management strategies in women with takotsubo cardiomyopathy

Locus of control and stress management strategies in women with takotsubo cardiomyopathy

HSP70 inhibits stress-induced cardiomyocyte apoptosis by competitively binding to FAF1

Effects of late‐night eating of easily—or slowly—digestible meals on sleep, hypothalamo‐pituitary‐adrenal axis, and autonomic nervous system in healthy young males

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