Cortisol level predicts myocardial infarction in patients with ischaemic chest pain

Bain, R.J.I.; Poeppinghaus, Vji; Jones, G. Melvill; Peaston, M. J. T.

doi:10.1016/0167-5273(89)90164-2

Cited by 20 publications

(13 citation statements)

References 17 publications

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“…Firstly, AMI is an inflammatory related disease, which may increase neutrophil percentage, and therefore, eosinophil percentage is decreased (21,22). Second, during the development of AMI, cortisol level is increased (23), which can decrease the peripheral eosinophil percentage (24,25), as also noticed in additional studies investigating the acute behavior of eosinophils in stress conditions (26). Although we failed to find the independent prognostic value of eosinophil for AMI, this may be due to the small sample size of our study, and we believe that further studies with large sample sizes may be needed to investigate the prognostic value of eosinophil percentage in patients with this condition.…”

Section: Discussionmentioning

confidence: 99%

Lower mean corpuscular hemoglobin concentration is associated with poorer outcomes in intensive care unit admitted patients with acute myocardial infarction

Huang¹,

Hu²

2016

Annals of Translational Medicine

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Background: Accumulated studies have shown that hematological parameters [e.g., red blood cell distribution width (RDW), hemoglobin, platelet count] and serum potassium level can impact the prognosis of patients with acute myocardial infarction (AMI). However, no previous study has evaluated the prognostic values of these laboratory tests simultaneously.Methods: This study is based on an intensive care unit (ICU) database named Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC II). Adult patients with AMI were included, and their hematological parameters and serum ion levels on admission were extracted. The relationships between these laboratory tests and hospital mortality were evaluated using a logistic regression model and receiver operating characteristic (ROC) curve analysis. The effects of these laboratory tests on 1-year mortality were evaluated using a Cox hazard regression model and Kaplan-Meier curve analysis.Results: In univariable analysis, increased white blood cell (WBC), neutrophil percentage, mean corpuscular volume (MCV), RDW, potassium and decreased red blood cell (RBC), hemoglobin, mean corpuscular hemoglobin concentration (MCHC), hematocrit and percentage of lymphocyte, monocyte, basophil and eosinophil were significantly associated with hospital mortality. In multivariable analyses, basophil percentage, potassium, WBC and MCHC were independently associated with hospital morality, while WBC, RDW, MCHC, potassium and percentages of neutrophil and lymphocyte were associated with 1-year mortality.Conclusions: Hematological parameters and serum potassium can provide prognostic information in AMI patients. MCHC is an independent prognostic factor for both short and long term outcomes of AMI.

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Section: Discussionmentioning

confidence: 99%

Lower mean corpuscular hemoglobin concentration is associated with poorer outcomes in intensive care unit admitted patients with acute myocardial infarction

Huang¹,

Hu²

2016

Annals of Translational Medicine

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“…-qualitä-ten nachweisen. Ob es tatsächlich bei akuten Schmerzereignissen eine solche Korrelation gibt, wird gegenwärtig kontrovers diskutiert: Während es bei schmerzhafter Angina pectoris zu keinem nennenswerten Kortisolanstieg kommt, korreliert der oft dramatische Anstieg beim Myokardinfarkt nur mit der Größe des Infarktareals, sodass die meisten Autoren eine monokausale Korrelation mit dem Schmerzereignis ablehnen und stattdessen eine multifaktorielle Ursache des Kortisolanstiegs im Sinne einer sekundären Stressantwort des Organismus vermuten [2,35].…”

Section: Akute Schmerzenunclassified

Funktionsst�rung der hypothalamisch-hyphophys�r-adrenalen Achse bei Patienten mit akuten, chronischen und intervallartigen Schmerzsyndromen

Strittmatter¹,

Bianchi²,

Ostertag

et al. 2005

Schmerz

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Pain experiences cause increased plasma cortisol levels with significant elevation of the daily average. Whereas in cases of acute pain, a direct but unspecific stress reaction not connected with the pain seems to be likely, the underlying cause in cases of chronic and episodic pain appears to be a complex and enduring activation of the hypothalamic-pituitary-adrenal axis, likewise independent from pain, probably associated with concomitant depressive symptoms and disruption of the circadian rhythm of release controlled by the hypothalamus.

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“…Coronary artery calcification is associated with flattened cortisol profiles over the day in middle-aged adults [5]. A prospective association between cortisol and future CHD has been documented in middle-aged men [6], while acute cortisol elevation following ACS predicts adverse cardiac outcomes [7,8]. Raised cortisol concentrations also predict mortality in patients with chronic heart failure [9].…”

Section: Introductionmentioning

confidence: 98%

Depression is associated with flatter cortisol rhythms in patients with coronary artery disease

Bhattacharyya

Molloy

Steptoe

2008

Journal of Psychosomatic Research

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Cortisol level predicts myocardial infarction in patients with ischaemic chest pain

Cited by 20 publications

References 17 publications

Lower mean corpuscular hemoglobin concentration is associated with poorer outcomes in intensive care unit admitted patients with acute myocardial infarction

Lower mean corpuscular hemoglobin concentration is associated with poorer outcomes in intensive care unit admitted patients with acute myocardial infarction

Funktionsst�rung der hypothalamisch-hyphophys�r-adrenalen Achse bei Patienten mit akuten, chronischen und intervallartigen Schmerzsyndromen

Depression is associated with flatter cortisol rhythms in patients with coronary artery disease

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