Cortisol promotes differentiation of epidermal ionocytes through Foxi3 transcription factors in zebrafish (Danio rerio)

Cruz, Shelly A.; Chao, Pei-Lin; Hwang, Pung‐Pung

doi:10.1016/j.cbpa.2012.09.011

Cited by 52 publications

(68 citation statements)

References 72 publications

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“…Furthermore, it was demonstrated that cortisol treatment stimulated the mRNA expression of glial cell missing-2 (gcm2) (Kumai et al, 2014b) and forkhead box I3 (foxi3a and foxi3b) (Cruz et al, 2013a), which are transcription factors critically involved in ionocyte development in zebrafish (Chang et al, 2009;Kumai et al, 2014b;Shono et al, 2011). Similarly, GR knockdown was shown to decrease the numbers of HRCs and NaRCs (Cruz et al, 2013b).…”

Section: Cortisolmentioning

confidence: 94%

Neuroendocrine control of ionic balance in zebrafish

Kwong

Kumai

Perry

2016

General and Comparative Endocrinology

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Section: Cortisolmentioning

confidence: 94%

Neuroendocrine control of ionic balance in zebrafish

Kwong

Kumai

Perry

2016

General and Comparative Endocrinology

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“…A previous study by Hoshijima and Hirose demonstrated that acclimation of zebrafish to ion-poor water increased the mRNA expression of atrial natriuretic peptide, renin, growth hormone and parathyroid hormone; however, their role in ion homeostasis and acid-base balance remain poorly understood. To date, only cortisol (Cruz et al, 2013;Kumai et al, 2012a), isotocin (Chou et al, 2011), prolactin (Breves et al, 2013 and catecholamines (Kumai et al, 2012b) have been implicated in regulating Na + uptake in zebrafish. In particular, cortisol is thought to play a major role in regulating Na + uptake in acid-exposed zebrafish.…”

Section: Endocrine Responses To Acid Stressmentioning

confidence: 99%

“…HRCs and NaRCs). Cruz et al (Cruz et al, 2013) demonstrated that cortisol treatment increased the proliferation of NaRCs and HRCs in zebrafish larval skin and adult gill through its stimulatory effects on foxi3a/3b, transcription factors involved in the regulation of ionocyte differentiation Esaki et al, 2009;Hsiao et al, 2007;Jänicke et al, 2007). Because of the increase in wholebody cortisol levels in acid-exposed larvae, the role of cortisol in ionocyte proliferation/epidermal development offers an attractive mechanism to explain the observed increase in HRCs in response to acid exposure.…”

Section: Endocrine Responses To Acid Stressmentioning

confidence: 99%

The physiology of fish at low pH: the zebrafish as a model system

Kwong

Kumai

Perry

2014

Journal of Experimental Biology

119

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Ionic regulation and acid-base balance are fundamental to the physiology of vertebrates including fish. Acidification of freshwater ecosystems is recognized as a global environmental problem, and the physiological responses to acid exposure in a few fish species are well characterized. However, the underlying mechanisms promoting ionic and acid-base balance for most fish species that have been investigated remain unclear. Zebrafish (Danio rerio) has emerged as a powerful model system to elucidate the molecular basis of ionic and acid-base regulation. The utility of zebrafish is related to the ease with which it can be genetically manipulated, its suitability for state-of-the-art molecular and cellular approaches, and its tolerance to diverse environmental conditions. Recent studies have identified several key regulatory mechanisms enabling acclimation of zebrafish to acidic environments, including activation of the sodium/hydrogen exchanger (NHE) and H + -ATPase for acid secretion and Na + uptake, cortisol-mediated regulation of transcellular and paracellular Na + movements, and ionocyte proliferation controlled by specific cell-fate transcription factors. These integrated physiological responses ultimately contribute to ionic and acid-base homeostasis in zebrafish exposed to acidic water. In the present review, we provide an overview of the general effects of acid exposure on freshwater fish, the adaptive mechanisms promoting extreme acid tolerance in fishes native to acidic environments, and the mechanisms regulating ionic and acid-base balance during acid exposure in zebrafish. KEY WORDS: Acid exposure, Acid-base balance, Ionic regulation, Zebrafish IntroductionDeclining fish populations in acidified lakes and streams (see review by McDonald, 1983a) was a significant factor promoting intensive research over the past 40 years on the ecological and physiological consequences of aquatic acidification. In freshwater (FW) ecosystems, acidification is caused largely by atmospheric acidic deposition (i.e. acid rain). Acidification of FW is a global problem, which has been documented in several geographic regions including eastern Europe, the USA and China (Psenner, 1994;Schindler, 1988;Wright et al., 2005). In Canada, it is estimated that about 40% of lakes are in regions susceptible to acid deposition (Kelso et al., 1990). Most aquatic animals, including fish, live in a narrow range of pH near neutrality, and acute or chronic exposure to acidic water can adversely affect their physiological functions (McDonald, 1983a;Wood, 1989). Nevertheless, some species thrive in acidic environments, and thus can serve as useful models for investigating the mechanisms underlying adaptation to acid stress. REVIEWDepartment of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, Canada, K1N 6N5.*Author for correspondence (wkwong@uottawa.ca)The mechanisms of ionic and acid-base regulation in fish have been summarized in previous reviews (Claiborne et al., 2002;Evans et al., 2005;Gilmour and Perry, 2009;Goss et al., 19...

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“…1F) to modulate ionoregulatory functions in the early embryo. Previous work has revealed that cortisol and isotocin help regulate ionocyte differentiation at various levels in the ionocyte lineage (Chou et al, 2011; Cruz et al, 2013), suggesting complex hormonal control of ionocyte differentiation and function. Given the remarkable similarity in the differentiation programs between ionocytes and intercalated cells of mammalian kidney (Hwang and Chou, 2013), the study of hormonal action on zebrafish ionocyte differentiation may provide insight into whether and how prolactin and other pituitary hormones direct cell differentiation in incipient renal tubules.…”

Section: Working Models For Prolactin Action On Ionocyte Populationsmentioning

confidence: 99%

Prolactin and teleost ionocytes: New insights into cellular and molecular targets of prolactin in vertebrate epithelia

Breves

McCormick

Karlstrom

2014

General and Comparative Endocrinology

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The peptide hormone prolactin is a functionally versatile hormone produced by the vertebrate pituitary. Comparative studies over the last six decades have revealed that a conserved function for prolactin across vertebrates is the regulation of ion and water transport in a variety of tissues including those responsible for whole-organism ion homeostasis. In teleost fishes, prolactin was identified as the “freshwater-adapting hormone”, promoting ion-conserving and water-secreting processes by acting on the gill, kidney, gut and urinary bladder. In mammals, prolactin is known to regulate renal, intestinal, mammary and amniotic epithelia, with dysfunction linked to hypogonadism, infertility, and metabolic disorders. Until recently, our understanding of the cellular mechanisms of prolactin action in fishes has been hampered by a paucity of molecular tools to define and study ionocytes, specialized cells that control active ion transport across branchial and epidermal epithelia. Here we review work in teleost models indicating that prolactin regulates ion balance through action on ion transporters, tight-junction proteins, and water channels in ionocytes, and discuss recent advances in our understanding of ionocyte function in the genetically and embryonically accessible zebrafish (Danio rerio). Given the high degree of evolutionary conservation in endocrine and osmoregulatory systems, these studies in teleost models are contributing novel mechanistic insight into how prolactin participates in the development, function, and dysfunction of osmoregulatory systems across the vertebrate lineage.

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Cortisol promotes differentiation of epidermal ionocytes through Foxi3 transcription factors in zebrafish (Danio rerio)

Cited by 52 publications

References 72 publications

Neuroendocrine control of ionic balance in zebrafish

Neuroendocrine control of ionic balance in zebrafish

The physiology of fish at low pH: the zebrafish as a model system

Prolactin and teleost ionocytes: New insights into cellular and molecular targets of prolactin in vertebrate epithelia

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