Cortisol Secretion in Stressed Babies during the Neonatal Period

Economou, George C.; Andronikou, Stiliani; Challa, Anna; Cholevas, Vasileios; Lapatsanis, P

doi:10.1159/000183798

Cited by 32 publications

(31 citation statements)

References 11 publications

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“…It has also been suggested that a reversed rhythm may be associated with chronic stress [23]. A similar finding was reported by Economou et al [45 ]who studied sick preterm and term infants in the first week of life, and found that grouped F means were higher at 20:00 h than at 08:00 and 14:00 h. Preterm infants are exposed to a variety of noxious stimuli, and may become hypersensitive to physical stimuli [46]. The concept of ‘wind-up’, where infants perceive non-noxious stimuli as ‘pain’, is now widely accepted [47].…”

Section: Discussionsupporting

confidence: 76%

Lack of Adult-Type Salivary Cortisol Circadian Rhythm in Hospitalized Preterm Infants

et al. 2005

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Background/Aims: Knowledge of the presence or absence of cortisol (F) circadian rhythm in preterm infants is important for the interpretation of F measurements made in samples taken for both clinical and research purposes. Little is known about its emergence in very preterm infants. This study examines circadian rhythm in F secretion in hospitalized infants born before 30 weeks’ gestation. Methods: Design: Prospective longitudinal observational study. Subjects: 11 infants admitted consecutively and born before 30 completed weeks of gestation. Measurements: F was measured by highly specific radioimmunoassay on morning and evening saliva samples gathered at weekly intervals until discharged home. Circadian rhythm was defined as ≧40% reduction from morning to evening level. Results: For all data, the median salivary F was 10.3 nmol/l (range <0.5–372.8). F levels were highest in the first 3 weeks of life. No infants displayed classical circadian rhythm for 4 weeks or more prior to being discharged from hospital. The other infants showed randomly distributed morning and evening F values with a trend in 4 infants towards periods of consistently higher evening than morning values. Conclusion: Adult-type F circadian rhythm is rarely evident in hospitalized preterm infants born before 30 weeks’ gestation.

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Section: Discussionsupporting

confidence: 76%

Lack of Adult-Type Salivary Cortisol Circadian Rhythm in Hospitalized Preterm Infants

et al. 2005

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“…The primary focus was not necessarily on CCR development [64]. The results from studies on preterm infants were either in line with ours regarding time for onset of CCR [70,74], or the studies were not designed to cover that time period (one month CA) [68,69,[71][72][73]. De Weerth et al investigated the dynamics of cortisol levels among infants age nine months, with risk factors similar to our group of infants at high psychosocial risk, and concluded that high maternal stress predicts high infant cortisol levels with high total AUC; our findings of high variability in AUC along with CCR curves that do not flatten over time are consistent with these results.…”

Section: Development Of Salivary Cortisol Circadian Rhythmmentioning

confidence: 83%

“…Cortisol levels peak in the morning and subsequently drop to a nadir in the evening [59,60] Seven earlier studies have explored the development of CCR in preterm infants [68][69][70][71][72][73][74], three of which investigated cortisol in saliva [69][70][71]. To date, there has been no general consensus regarding when CCR is established.…”

Section: Cortisol Circadian Rhythmmentioning

confidence: 99%

“…Seven earlier studies have investigated development of salivary CCR in full-term infants [61][62][63][64][65][66][67] and an additional seven studies have investigated CCR development in preterm infants [68][69][70][71][72][73][74] (saliva, plasma, or serum), whereas only one study has examined CCR in high psychosocial risk infants at <twelve months of age [100] (saliva).…”

Section: Development Of Salivary Cortisol Circadian Rhythmmentioning

confidence: 99%

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Stress : Clinical and Developmental Aspects of Salivary Cortisol in Infants

Ivars¹

2016

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A functional stress-response system is essential for survival at birth, as well as for health and further development. Altered cortisol response and hypothalamic-pituitary-adrenal system function may have both short and long-term effects on health and development throughout life. Cortisol secretion follows a circadian rhythm in adults. Data in the literature concerning basal cortisol levels is scant, with divergent results regarding the timeframe for establishment of cortisol circadian rhythm in children. Nevertheless, cortisol is often studied in stress-related research concerning preterm infants, full-term infants, and infants at high psychosocial risk. This thesis aimed to investigate at what age cortisol circadian rhythm develops in healthy full-term infants, preterm infants, and infants at high psychosocial risk and to identify whether such development is dependent on gestational or postnatal age. A secondary aim was to investigate whether either behavioral regularity or daily life trauma are associated with establishment of cortisol circadian rhythm. The last two interventional studies explored whether a) parental participation in the Hagadal daycare attachment program in one study and b) oral administration of glucose during nasopharyngeal suctioning in the other study influenced development of salivary cortisol circadian rhythm and/or cortisol levels. The effects, if any, of the Hagadal daycare attachment program on caregiver sensitivity to infants were also investigated. The present thesis includes four original studies. Papers I, II, and III describes prospective, longitudinal studies extending over a year, including a survey of the cortisol levels and development of cortisol circadian rhythm in three infant groups. Paper III also included an intervention component addressing the possible effects of the Hagadal daycare attachment program. Paper IV describes a case-control study designed to generate paired baseline-response data concerning the effects of oral glucose administration during nasopharyngeal suctioning as an interventional procedure. Cortisol circadian rhythm in salivary cortisol secretion was similarly established at one month postnatal age in full-term infants and at one month corrected age in preterm infants, reflecting a process dependent on gestational age. This rhythm persisted throughout the first year of life in all infants and consolidated over time in healthy full-term and preterm infants, but not in infants at high psychosocial risk, who displayed higher variability in cortisol levels. The infants in paper IV had not yet reached one month of corrected age and therefore had not yet developed cortisol circadian rhythm at the time of the investigation. No correlation was found between development of cortisol circadian rhythm and either behavioral regularity or reported traumatic life events. This thesis presents data on salivary cortisol levels among three different groups of infants during the first year of life. Cortisol circadian rhythm among infants in study III evolved in respon...

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“…Preterm infantlarda akut hastalık sırasında adrenal korteksin sekretuvar kapasitesindeki düşmenin bu cevabın yetersizliğinde rol olabileceği düşünülmektedir 5 . Yenidoğan döneminde adrenal korteks fonksiyonları ile, respiratuvar distres sendromu, gestasyonel yaş, doğum ağırlığı ve arteriyel hipotansiyon gibi bir çok faktör ilişkili bulunmuştur 6,7 Öte yandan bazı prematüre bebeklerde respiratuvar distres sendromu gelişmemektedir. Teorik olarak bu konunun ve hastalığın postnatal seyrinin bebeğin strese endojen cevabı ile ilişkili olma ihtimali vardır.…”

Section: Introductionunclassified

Endogenous Cortisol Response in Infants with Respiratory Distress Syndrome

Çetişli¹,

Elmas²,

Çetin³

2016

Sakarya Med J

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ÖzAmaç Respiratuvar distres sendromu (RDS), prematüre bebeklerde morbidite ve mortalitenin en önemli nedenidir. RDS 'nin gelişmesinde en önemli faktör gestasyonel yaş olmakla birlikte bazı maternal ve fetal faktörler de hastalığın gelişmesinde etkilidir. Steroidlerin c-AMP (siklik adenozin monofosfat) yolu ile sürfaktan yapımını ve doğum eylemi sırasında sürfaktan sekresyonunu stimüle ettiği bilinmektedir. Bazı prematüre bebeklerde RDS gelişmemektedir. Bu hastalığın postnatal seyrinin bebeğin strese endojen cevabı ile ilişkili olma ihtimalini düşündürmektedir. Bu çalışmada, RDS gelişen bebeklerin stres karşısında endojen kortizol yanıtları araştırıldı. Gereç ve YöntemlerGestasyonel yaşları 28-35 hafta arasında değişen respiratuvar distres sendromlu 20 bebek, hafif solunum distresli 19 bebek ve sağlıklı 25 bebekte postnatal 2-8. saatte ve 2.gün kortizol düzeyleri çalışıldı.

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Cortisol Secretion in Stressed Babies during the Neonatal Period

Cited by 32 publications

References 11 publications

Lack of Adult-Type Salivary Cortisol Circadian Rhythm in Hospitalized Preterm Infants

Lack of Adult-Type Salivary Cortisol Circadian Rhythm in Hospitalized Preterm Infants

Stress : Clinical and Developmental Aspects of Salivary Cortisol in Infants

Endogenous Cortisol Response in Infants with Respiratory Distress Syndrome

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