In the past two decades there have been significant gains in our understanding of prevention and education related to lung disease, much of it enabled by research sponsored by the Division of Lung Diseases (DLD) of the National Heart, Lung, and Blood Institute (NHLBI). This paper will discuss the evolution of the prevention and education knowledge base through focus on three dimensions of research. First, it will use chronic obstructive pulmonary disease (COPD) as a case for examining advances in our ability to screen and identify patients at risk for developing disease. It will illustrate that COPD research has moved us closer to being able to identify populations that should benefit from early and targeted interventions. Second, it will examine the literature on smoking, perhaps the most damaging of all health-related behaviors because of its strong association with a range of respiratory conditions. The aim will be to assess recent contributions to intervention research on efforts to prevent or reduce smoking as a risk factor in lung disease. Third, it will explore the extant research related to asthma education and describe the development of the National Asthma Education and Prevention Program (NAEPP). It will discuss how research and educational initiatives in asthma have contributed to advances in disease management by patients, including changes in self-management behavior, health status, health care use, and the quality of life.The concluding section of the paper will consider future research directions. Given how far prevention and education research have taken us, where are the gaps in our knowledge and what are the priority areas for further investigation?
SCREENING AND PREVENTION IN COPDChronic obstructive pulmonary disease is now the fourth common cause of death in the United States (1), and it is expected that 110,000 or more deaths from COPD will occur during 1997 alone. Chronic obstructive pulmonary disease is an extremely common disease, but because it is relatively asymptomatic early in its course, most would agree that the currently estimated prevalence of 16 million cases, based on physician diagnosis, probably represents less than half the cases that would be identified if screening spirometry were to be performed. The greatest cause of COPD is smoking, but many smokers do not develop COPD. If screening spirometry was performed on all smokers, those most likely to develop COPD could be identified early, and efforts to prevent and treat this disabling and lethal disease could then be focused on those individuals at greatest risk.Research over the past 30 years has increased our understanding of the basic mechanisms of COPD ( see review by Anthonisen and Senior, this issue, p. S139), its pathogenesis, the varying pathologic entities encompassing this disorder, including chronic obstructive bronchitis, emphysema, and asthmatic bronchitis, and much about the epidemiology of this disease. The natural history of COPD is characterized by a slow, progressive limitation of maximal expiratory airflow....