Cortitrol supplementation reduces serum cortisol responses to physical stress

Kraemer, William J.; French, Duncan N.; Spiering, Barry A.; Volek, Jeff S.; Sharman, Matthew J.; Ratamess, Nicholas A.; Judelson, Daniel A.; Silvestre, Ricardo; Watson, Greig; Gómez, Ana L.; Maresh, Carl M.

doi:10.1016/j.metabol.2004.12.010

Cited by 24 publications

(25 citation statements)

References 40 publications

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“…All groups displayed a significant reduction in Pre-Ex CORT concentrations at week 12 compared to week 0, an adaptation to resistance training that is consistent with previous reports (Staron et al 1994;Kraemer et al 1999;Tarpenning et al 2001). The implications of repeated modification of the acute exercise-induced CORT response may be inferred from the work of Kraemer et al (2005), who suggest that an accumulated reduction in CORT concentrations results in reduced total tissue exposure to CORT, thereby influencing the subsequent phase of recovery by modulating anabolic and catabolic processes (Kraemer et al 1998b). In the current investigation, changes in fCSA were significantly correlated with the change in CORT response, during week 0, when all data were combined.…”

Section: Discussionsupporting

confidence: 86%

“…The resultant physiological stress associated with resistance exercise protocols designed to maximally stimulate the major muscle groups (i.e., whole-body; moderate volume, high intensity) often produces hypersecretion of cortisol (CORT) >500 nmol l À1 (Tarpenning et al 2001;Bird et al 2005;Kraemer et al 2005), while insulin (INS) levels remain unchanged (Roy et al 1997) or decrease (Raastad et al 2000). Infusion studies have shown that elevated systemic cortisol results in net muscle protein catabolism (Simmons et al 1984;Gore et al 1993).…”

Section: Introductionmentioning

confidence: 99%

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Independent and combined effects of liquid carbohydrate/essential amino acid ingestion on hormonal and muscular adaptations following resistance training in untrained men

2006

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This investigation examined chronic alteration of the acute hormonal response associated with liquid carbohydrate (CHO) and/or essential amino acid (EAA) ingestion on hormonal and muscular adaptations following resistance training. Thirty-two untrained young men performed 12 weeks of resistance training twice a week, consuming ~675 ml of either, a 6% CHO solution, 6 g EAA mixture, combined CHO + EAA supplement or placebo (PLA). Blood samples were obtained pre- and post-exercise (week 0, 4, 8, and 12), for determination of glucose, insulin, and cortisol. 3-Methylhistidine excretion and muscle fibre cross-sectional area (fCSA) were determined pre- and post-training. Post-exercise cortisol increased (P<0.05) during each training phase for PLA. No change was displayed by EAA; CHO and CHO + EAA demonstrated post-exercise decreases (P<0.05). All groups displayed reduced pre-exercise cortisol at week 12 compared to week 0 (P<0.05). Post-exercise insulin concentrations showed no change for PLA; increases were observed for the treatment groups (P<0.05), which remained greater for CHO and CHO + EAA (P<0.001) than PLA. EAA and CHO ingestion attenuated 3-methylhistidine excretion 48 h following the exercise bout. CHO + EAA resulted in a 26% decrease (P<0.01), while PLA displayed a 52% increase (P<0.01). fCSA increased across groups for type I, IIa, and IIb fibres (P<0.05), with CHO + EAA displaying the greatest gains in fCSA relative to PLA (P<0.05). These data indicate that CHO + EAA ingestion enhances muscle anabolism following resistance training to a greater extent than either CHO or EAA consumed independently. The synergistic effect of CHO + EAA ingestion maximises the anabolic response presumably by attenuating the post-exercise rise in protein degradation.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Independent and combined effects of liquid carbohydrate/essential amino acid ingestion on hormonal and muscular adaptations following resistance training in untrained men

2006

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“…The rigor of FERG workouts also contributed to the current time effect. Research notes workouts against heavy loads evoke time effects, because athletes will incur higher [C] than sedentaries who perform similar protocols (23,25,(30)(31)(32)(33)38). Finally multisprint (32,41) and 2-hour running protocols (12) each elevated [C], because the former produced values like current results.…”

Section: Discussionmentioning

confidence: 64%

“…Postexercise [GH] usually peak within 15 minutes because of the volume of work performed (1,2,19,34,44). Although the CO6 workout provided an expected response, whereby a higher TW volume evoked a greater [GH] at 1 minute postexercise and the latter declined (33,45), CE3 had the opposite effect, which suggests that eccentric actions delay postexercise [GH] increases.…”

Section: Discussionmentioning

confidence: 99%

Blood Lactate and Hormonal Responses to Prototype Flywheel Ergometer Workouts

Caruso

Coday²,

Monda³

et al. 2010

Journal of Strength and Conditioning Research

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The purpose of the study was to compare blood lactate and hormonal responses with flywheel ergometer (FERG) leg presses for preliminary assessment of workouts best suited for future in-flight resistance exercise. Comprised of 10 repetition sets, the workouts entailed 3 sets of concentric and eccentric (CE3) actions, or concentric-only actions done for 3 (CO3) or 6 (CO6) sets. Methods employed included assessment of blood lactate concentrations ([BLa-]) before and 5 minutes postexercise. Venous blood was also collected before and at 1 and 30 minutes postexercise to assess growth hormone, testosterone, cortisol concentrations ([GH], [T], [C]) and [T/C] ratios. [BLa-] were compared with 2 (time) x 3 (workout) analysis of variance. Hormones were assessed with 2 (gender) x 3 (time) x 3 (workout) analysis of covariances. Results showed [BLa-] had a time effect. Growth hormone concentration showed gender x workout, gender x time, and workout x time interactions, whereas [T] had a 3-way interaction. [C] had gender, time, and workout effects. [T/C] yielded a gender x time interaction. It was concluded that, because CO6 and CE3 yielded similar anabolic hormonal data but the latter had a lower [C] 30 minutes postexercise, CE3 served as the best workout. Although the FERG was originally designed for microgravity, the effort put forth by current subjects was like that for workouts aimed at greater athletic performance and conditioning. Practical applications suggest that eccentric actions should be used for FERG workouts geared toward muscle mass and strength improvement.

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“…OS → Adrenal hormone alterations OS and resulting reduced cell energy can trigger stress hormone activation and altered regulation (cortisol supports glucose as a cell energy substrate) (Aschbacher et al, 2013;Ghiciuc et al, 2013;Joergensen et al, 2011;Kraemer et al, 2005;Schmoller et al, 2009). Brain cell death is amplified when cell energy depletion is coupled with glucocorticoids/ stress hormones (Sapolsky & Pulsinelli, 1985).…”

Section: Branch Of Model Nr Relationshipmentioning

confidence: 99%

Coenzyme Q10 Benefits Symptoms in Gulf War Veterans: Results of a Randomized Double-Blind Study

et al. 2014

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We sought to assess whether coenzyme Q10 (CoQ10) benefits the chronic multisymptom problems that affect one-quarter to one-third of 1990-1 Gulf War veterans, using a randomized, double-blind, placebo-controlled study. Participants were 46 veterans meeting Kansas and Centers for Disease Control criteria for Gulf War illness. Intervention was PharmaNord (Denmark) CoQ10 100 mg per day (Q100), 300 mg per day (Q300), or an identical-appearing placebo for 3.5 ± 0.5 months. General self-rated health (GSRH), the primary outcome, differed across randomization arms at baseline, and sex significantly predicted GSRH change, compelling adjustment for baseline GSRH and prompting sex-stratified analysis. GSRH showed no significant benefit in the combined-sex sample. Among males (85% of participants), Q100 significantly benefited GSRH versus placebo and versus Q300, providing emphasis on Q100. Physical function (summary performance score, SPS) improved on Q100 versus placebo. A rise in CoQ10 approached significance as a predictor of improvement in GSRH and significantly predicted SPS improvement. Among 20 symptoms each present in half or more of the enrolled veterans, direction-of-difference on Q100 versus placebo was favorable for all except sleep problems; sign test 19:1, p=0.00004) with several symptoms individually significant. Significance for these symptoms despite the small sample underscores large effect sizes, and an apparent relation of key outcomes to CoQ10 change increases prospects for causality. In conclusion, Q100 conferred benefit to physical function and symptoms in veterans with Gulf War illness. Examination in a larger sample is warranted, and findings from this study can inform the conduct of a larger trial.

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Cortitrol supplementation reduces serum cortisol responses to physical stress

Cited by 24 publications

References 40 publications

Independent and combined effects of liquid carbohydrate/essential amino acid ingestion on hormonal and muscular adaptations following resistance training in untrained men

Independent and combined effects of liquid carbohydrate/essential amino acid ingestion on hormonal and muscular adaptations following resistance training in untrained men

Blood Lactate and Hormonal Responses to Prototype Flywheel Ergometer Workouts

Coenzyme Q10 Benefits Symptoms in Gulf War Veterans: Results of a Randomized Double-Blind Study

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