Corydalis saxicola Bunting: A Review of Its Traditional Uses, Phytochemistry, Pharmacology, and Clinical Applications

Feng, Qicheng; Chen, Yao; Wang, Fan‐Fan; Tang, Shaoqing; Fang, Yi-Lin

doi:10.3390/ijms24021626

Cited by 11 publications

(3 citation statements)

References 20 publications

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“…Among the medicinal Corydalis species, C. saxicola is widely used in Traditional Chinese Medicine due to its antibacterial, antiviral and anticancer activities ( Orhan et al., 2007 ; Kim et al., 2010 ; Li et al., 2013 ; Kim et al., 2014 ; Tian et al., 2016 ; Zhang et al., 2016 ; Liu et al., 2019 ; Feng et al., 2023 ; Qin et al., 2023b ). Studies suggest that these pharmacological activities are due to the presence of unique benzylisoquinoline alkaloid compounds known as cavidines (e.g., cavidine, apocavidine, dehydrocavidine and dehydroapocavidine) ( Bhakuni and Chaturvedi, 1983 ; Qin et al., 2023a ). As a calcicole plant, C. saxicola is found exclusively in and around the rocky crevices of calcium-rich karst landscapes.…”

Section: Introductionmentioning

confidence: 99%

RNA editing events and expression profiles of mitochondrial protein-coding genes in the endemic and endangered medicinal plant, Corydalis saxicola

Li,

Liu,

Qin

et al. 2024

Front. Plant Sci.

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Corydalis saxicola, an endangered medicinal plant endemic to karst habitats, is widely used in Traditional Chinese Medicine to treat hepatitis, abdominal pain, bleeding hemorrhoids and other conditions. However, to date, the mitochondrial (mt) genome of C. saxicola has not been reported, which limits our understanding of the genetic and biological mechanisms of C. saxicola. Here, the mt genome of C. saxicola was assembled by combining the Nanopore and Illumina reads. The mt genome of C. saxicola is represented by a circular chromosome which is 587,939 bp in length, with an overall GC content of 46.50%. 40 unique protein-coding genes (PCGs), 22 tRNA genes and three rRNA genes were identified. Codon usage of the PCGs was investigated and 167 simple sequence repeats were identified. Twelve homologous fragments were identified between the mt and ct genomes of C. saxicola, accounting for 1.04% of the entire mt genome. Phylogenetic examination of the mt genomes of C. saxicola and 30 other taxa provided an understanding of their evolutionary relationships. We also predicted 779 RNA editing sites in 40 C. saxicola mt PCGs and successfully validated 506 (65%) of these using PCR amplification and Sanger sequencing. In addition, we transcriptionally profiled 24 core mt PCGs in C. saxicola roots treated with different concentrations of CaCl2, as well as in other organs. These investigations will be useful for effective utilization and molecular breeding, and will also provide a reference for further studies of the genus Corydalis.

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Section: Introductionmentioning

confidence: 99%

RNA editing events and expression profiles of mitochondrial protein-coding genes in the endemic and endangered medicinal plant, Corydalis saxicola

Li,

Liu,

Qin

et al. 2024

Front. Plant Sci.

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“…Papaveraceae is renowned for the opium poppy (Papaver somniferum), which can serve as a source of analgesic drugs [27]. In addition, Corydalis yanhusuo, Dactylicapnos torulosa, Chelidonium majus, Macleaya cordata, Hylomecon japonica, Hypecoum erectum, and Eomecon chionantha are also used in traditional medicine [28][29][30][31][32][33][34]. The taxonomy and phylogeny of Papaveraceae have been a subject of ongoing debate.…”

Section: Introductionmentioning

confidence: 99%

Extreme Reconfiguration of Plastid Genomes in Papaveraceae: Rearrangements, Gene Loss, Pseudogenization, IR Expansion, and Repeats

Cao,

Wang,

Cao

et al. 2024

IJMS

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The plastid genomes (plastomes) of angiosperms are typically highly conserved, with extreme reconfiguration being uncommon, although reports of such events have emerged in some lineages. In this study, we conducted a comprehensive comparison of the complete plastomes from twenty-two species, covering seventeen genera from three subfamilies (Fumarioideae, Hypecooideae, and Papaveroideae) of Papaveraceae. Our results revealed a high level of variability in the plastid genome size of Papaveraceae, ranging from 151,864 bp to 219,144 bp in length, which might be triggered by the expansion of the IR region and a large number of repeat sequences. Moreover, we detected numerous large-scale rearrangements, primarily occurring in the plastomes of Fumarioideae and Hypecooideae. Frequent gene loss or pseudogenization were also observed for ndhs, accD, clpP, infA, rpl2, rpl20, rpl32, rps16, and several tRNA genes, particularly in Fumarioideae and Hypecooideae, which might be associated with the structural variation in their plastomes. Furthermore, we found that the plastomes of Fumarioideae exhibited a higher GC content and more repeat sequences than those of Papaveroideae. Our results showed that Papaveroideae generally displayed a relatively conserved plastome, with the exception of Eomecon chionantha, while Fumarioideae and Hypecooideae typically harbored highly reconfigurable plastomes, showing high variability in the genome size, gene content, and gene order. This study provides insights into the plastome evolution of Papaveraceae and may contribute to the development of effective molecular markers.

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“…Corydalis species are one of traditional Chinese medicines for pain relief, known for their anti-inflammatory and anticancer effects [14,15]. In traditional Chinese medicine, this substance is utilized for the treatment of various ailments, including abdominal pain, menstrual cramps, and bleeding hemorrhoids.…”

Section: Introductionmentioning

confidence: 99%

Acetylcorynoline Induces Apoptosis and G2/M Phase Arrest through the c-Myc Signaling Pathway in Colon Cancer Cells

Park,

Jee,

Park

et al. 2023

IJMS

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Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, and despite advances in treatment, survival rates are still low; therefore, the development of novel drugs is imperative. Acetylcorynoline (ACN) is derived from Corydalis ambigua Cham. et Schltdl tubers. The effect of ACN on colon cancer is still unknown. Therefore, we investigated its potential effects. Our data showed that ACN inhibited cell viability and proliferation. Moreover, ACN induced apoptosis and cell cycle arrest by inhibiting cell growth. In the present study, we hypothesized that ACN regulates c-Myc through CNOT2 or MID1IP1. ACN reduced the protein expression of oncogenic genes, decreased c-Myc half-life, and rapidly inhibited the serum stimulation response. Moreover, knockdown of CNOT2 and MID1IP1 with ACN increased apoptosis and further reduced the expression of oncogenes. In addition, ACN exhibited a synergistic effect with low-dose 5-fluorouracil (5-FU) and doxorubicin (Dox). Collectively, our data demonstrate that ACN inhibited c-Myc expression through CNOT2 and MID1IP1, and induced apoptosis. These findings indicate the potential of ACN as a therapeutic agent against colon cancer.

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Corydalis saxicola Bunting: A Review of Its Traditional Uses, Phytochemistry, Pharmacology, and Clinical Applications

Cited by 11 publications

References 20 publications

RNA editing events and expression profiles of mitochondrial protein-coding genes in the endemic and endangered medicinal plant, Corydalis saxicola

RNA editing events and expression profiles of mitochondrial protein-coding genes in the endemic and endangered medicinal plant, Corydalis saxicola

Extreme Reconfiguration of Plastid Genomes in Papaveraceae: Rearrangements, Gene Loss, Pseudogenization, IR Expansion, and Repeats

Acetylcorynoline Induces Apoptosis and G2/M Phase Arrest through the c-Myc Signaling Pathway in Colon Cancer Cells

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