Corynebacteria (including diphtheria)

Smith, Kelsy F.; Oram, Diana Marra

doi:10.1016/b978-012373944-5.00216-9

Cited by 8 publications

(10 citation statements)

References 6 publications

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“…In this study, the biomarkers species, S. epidermidis , S. liquefaciens , and K. pneumonia, which are found in deceased COVID-19 patients are well known bacterial pathogens. Similarly, C. xerosis resemble to C. amycolatum [ 35 ] which is a very close relative to C. diphtheriae may cause infection in immunocompromised patients [ 36 ]. Moreover, C. xerosis itself may cause several types of infections including endocarditis [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal microbiome of COVID-19 patients revealed a distinct bacterial profile in deceased and recovered individuals

Kumar¹,

Pandit²,

Sharma³

et al. 2022

Microbial Pathogenesis

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Section: Discussionmentioning

confidence: 99%

Nasopharyngeal microbiome of COVID-19 patients revealed a distinct bacterial profile in deceased and recovered individuals

Kumar¹,

Pandit²,

Sharma³

et al. 2022

Microbial Pathogenesis

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“…In this study, the biomarkers species, S. epidermidis, S. liquefaciens, and K. pneumoniae which are found in demised COVID-19 patients are well known pathogens. Similarly, C. xerosis resemble to C. amycolatum [20] which is a very close relative to C. diphtheriae may cause infection in immunocompromised patients [21]. Moreover, C. xerosis itself may cause several types of infections including endocarditis [22].…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal Microbiome of COVID-19 Patients Using 16S Amplicon Analysis Revealed Distinct Bacterial Profile in Demised and Recovered Individuals

Kumar¹,

Pandit²,

Sharma³

et al. 2021

Preprint

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Background COVID-19 pandemic has shaken the entire world and the socio-economic life on the planet. The implications of the bacterial co-infections in SARS-CoV-2 patients remained the least explored subject of clinical manifestations among the COVID-19. Identification and association of the nasopharyngeal microbial community structure within SARS-CoV-2 infected patients could reveal microbiota dynamics that may determine and/or influence the disease outcome in the COVID-19 patients. Results Here, in this study, we present distinct nasopharyngeal microbiome in the demised (N=48) and recovered (N=29) COVID-19 patients as compared to the control group (N=33). The nasal microbiome composition in the three groups vary significantly (PERMANOVA, p-value <0.001), where demised patients showed higher species richness as compared to the recovered and control groups. Pathogenic genera including Corynebacterium (LAD score 5.51), Staphylococcus, Serratia, Klebsiella and their corresponding species were found as biomarkers (p-value <0.05, LDA cutoff 4.0) in the patients those who demised due to SARS-CoV-2 infection. Except for a few pathogenic species in the genera, Ochrobactrum (LDA score 5.79), and Burkholderia (LDA 5.29), the recovered group harbors ordinal bacteria (p-value <0.05, LDA-4.0) as biomarkers. Similarly, Pseudomonas (LDA score 6.19), and several healthy oral/nasal cavity commensal including Veillonella, and Porphyroonas, were biomarkers for the control individuals. Conclusions Dysbiosis in the commensal nasopharyngeal microbiota, especially due to infection of opportunistic pathogens could lead to more complex and severe COVID-19 disease dynamics. Whereas, healthy commensal bacteria may trigger the immune response and alter the viral infection susceptibility and thus, may help in preventing the viral infection and possible recovery which is yet to be explored. The findings in the present study provide key considerations and have significant implications for the COVID-19 treatment and control measures. However, further study is required to address the microbiome based therapeutic aspects.

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“…Corynebacterium is genus within the phylum Actinobacteria and the order Actinomycetales and it involves a heterogeneous group of approximately 60 species that are easily differentiated through chemical analysis [1]. Bacteria belonging to the genus Corynebacterium can be found in a wide range of ecological niches such as dairy products, soil, sewage, plant surfaces, and aquatic environments [2].…”

Section: Introductionmentioning

confidence: 99%

“…Corynebacterium species also occur as normal flora in humans and animals [1,5,6]. However, there is very little information on the diversity and host range of this bacteria species in many parts of the world [1,5,6]. Previously nondiphtheria Corynebacterium species were considered to be none pathogenic strains within the genus.…”

Section: Introductionmentioning

confidence: 99%

Isolation of <i>Corynebacterium</i> Species from Retail Mutton and Lamb in the North West Province, South Africa

Dlamini¹,

Ateba²

2014

JFNR

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Corynebacterium species occur as part of the normal flora of animals and humans and there is very little information on the diversity and host range of these pathogens. Despite this, some Corynebacterium species have been reported to cause infections in both animals and humans. Infections usually result from the consumption of contaminated food products such as meat and milk as well as contact with infected animals. The aim of study was to isolate, identify and characterize Corynebacterium species from retail meat products obtained from some supermarkets in the North West Province, South Africa. A total of 25 mutton and lamb meat samples were purchased from some supermarket and butcheries in the North West Province, South Africa and bacteria was isolated using Colombia agar supplemented with 5% (w/v) bovine blood. Seventy five presumptive Corynebacterium isolates were obtained based on colonial morphology and these isolates were screened for characters of Corynebacterium species. Amongst these, 67 isolates were catalase positive while 54 were Gram positive rods. Twenty four representative isolates were not able to utilize urea and ferment glucose and maltose respectively. However 19 (79.2%) of these isolates were able to utilize nitrate and33% were positively identified as Corynebacterium species using API Coryne assay. Eleven percent of the isolates were positively identified as Corynebacterium species by 16S specific rRNA PCR analysis. From these results it was evident that Corynebacterium species were present in the raw meat products and the meat products could pose severe health risks to consumers, especially individuals who are immuno-compromised. This therefore amplifies the need to implement strict measures that limit the transmission of these pathogens through the food chain to consumers. Moreover, constant assessments of the health risks associated with contaminated food products in the South African market should be performed on routine basis.

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Corynebacteria (including diphtheria)

Cited by 8 publications

References 6 publications

Nasopharyngeal microbiome of COVID-19 patients revealed a distinct bacterial profile in deceased and recovered individuals

Nasopharyngeal microbiome of COVID-19 patients revealed a distinct bacterial profile in deceased and recovered individuals

Nasopharyngeal Microbiome of COVID-19 Patients Using 16S Amplicon Analysis Revealed Distinct Bacterial Profile in Demised and Recovered Individuals

Isolation of <i>Corynebacterium</i> Species from Retail Mutton and Lamb in the North West Province, South Africa

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