Corynebacterium macginleyi-associated Blebitis: A Case Report

Qin, Vincent; Laurent, Terry; Ledoux, A

doi:10.1097/ijg.0000000000001051

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…A diversity of type and degree of enrichment is not surprising, as Corynebacterium species comprise a diverse genus, with over 110 validated species (Oliveira et al 2017). Most human-associated Corynebacteria are considered commensals, commonly residing in the skin, upper respiratory tract, conjunctiva, and the urogenital tract (Ang and Brown 2007; Cogen et al 2008; Hemsley et al 1999; Qin et al 2018; Sokol-Leszczynska et al 2019). However, several species of Corynebacteria are known to be strictly pathogenic, most notoriously C. diphtheria (Bernard 2012; Cogen et al 2008).…”

Section: Resultsmentioning

confidence: 99%

Cutaneous surgical wounds have distinct microbiomes from intact skin

Gupta

Poret

Hashemi

et al. 2022

Preprint

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Background: Infections are relatively rare following cutaneous surgical procedures, despite the potential for wound exposure to pathogens both during surgery and throughout the healing process. Although gut commensals are believed to reduce the risk of intestinal infections, an analogous role for skin commensals has not been described. In fact, the microbiome of normally healing surgical skin wounds has not yet been profiled using culture-independent techniques. Results: We characterized the wound microbiome in 52 patients who underwent skin cancer surgery and healed without signs or symptoms of infection. A week after surgery, several bacterial species displayed significant differences in relative abundance when compared to control, non-operated skin from the same patient. The most common bacteria found on intact skin, Cutibacterium acnes, was depleted in wounds 5-fold. Surprisingly, Staphylococcus aureus, a frequent cause of postoperative skin infections, was enriched 6.4-fold in clinically non-infected wounds, suggesting active suppression of this pathogen. Finally, members of the Corynebacterium genus were the dominant organism is postoperative wounds, making up 37% of the average wound microbiome. Conclusion: We observed distinct bacterial communities in acute wounds a week after surgery and anatomically-matched normal skin from the same patient. Future studies focused on the biological and clinical significance of the wound microbiome may shed light on normal wound healing and potential therapeutic opportunities to mitigate infection risk.

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Section: Resultsmentioning

confidence: 99%

Cutaneous surgical wounds have distinct microbiomes from intact skin

Gupta

Poret

Hashemi

et al. 2022

Preprint

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“…Although C. macginleyi has been isolated from various types of infections, such as endocarditis, surgical site infections, and bladder catheter infections [ 37 , 38 , 39 ], the majority of C. macginleyi case reports are of ocular infections [ 14 ]. C. macginleyi has been isolated from cases of blebitis, conjunctivitis, endophthalmitis, and keratitis [ 35 , 40 , 41 , 42 , 43 ]. C. macginleyi has few known virulence factors, but this may be due to the lack of functional studies conducted with this species.…”

Section: Gram-positive Ocular Pathogensmentioning

confidence: 99%

Ocular Bacterial Infections: A Ten-Year Survey and Review of Causative Organisms Based on the Oklahoma Experience

Astley,

Mursalin,

Coburn

et al. 2023

Microorganisms

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Ocular infections can be medical emergencies that result in permanent visual impairment or blindness and loss of quality of life. Bacteria are a major cause of ocular infections. Effective treatment of ocular infections requires knowledge of which bacteria are the likely cause of the infection. This survey of ocular bacterial isolates and review of ocular pathogens is based on a survey of a collection of isolates banked over a ten-year span at the Dean McGee Eye Institute in Oklahoma. These findings illustrate the diversity of bacteria isolated from the eye, ranging from common species to rare and unique species. At all sampled sites, staphylococci were the predominant bacteria isolated. Pseudomonads were the most common Gram-negative bacterial isolate, except in vitreous, where Serratia was the most common Gram-negative bacterial isolate. Here, we discuss the range of ocular infections that these species have been documented to cause and treatment options for these infections. Although a highly diverse spectrum of species has been isolated from the eye, the majority of infections are caused by Gram-positive species, and in most infections, empiric treatments are effective.

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Other Corynebacteria

Norton¹,

Bratcher²

2023

Principles and Practice of Pediatric Infectious Diseases

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Corynebacterium macginleyi-associated Blebitis: A Case Report

Cited by 5 publications

References 17 publications

Cutaneous surgical wounds have distinct microbiomes from intact skin

Cutaneous surgical wounds have distinct microbiomes from intact skin

Ocular Bacterial Infections: A Ten-Year Survey and Review of Causative Organisms Based on the Oklahoma Experience

Other Corynebacteria

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