Corynebacterium--Nonmedical

Liebl, Wolfgang

doi:10.1007/0-387-30743-5_30

Cited by 39 publications

(36 citation statements)

References 179 publications

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“…It consists of 59 validly described species, of which two taxon groups and 35 species are medically relevant (von Graevenitz & Bernard, 2001). Nonmedical corynebacteria are widely disseminated in nature and have been isolated from a number of different environments other than soil, including dairy products, plant material, faeces and animal skin (Liebl, 2001). Except for phage-mediated transfer and a few conjugative plasmids, corynebacteria appear devoid of a natural competence system for exogenous DNA uptake (Vertès et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R

et al. 2007

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Section: Introductionmentioning

confidence: 99%

Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R

et al. 2007

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“…glutamicum can use a variety of carbohydrates and organic acids as carbon and energy sources (Kinoshita & Tanaka, 1972;Liebl, 1991). As carbon sources, glucose and acetate have been shown to serve as substrates for amino acid production by C. glutamicum.…”

Section: Introductionmentioning

confidence: 99%

Effect of carbon source availability and growth phase on expression of Corynebacterium glutamicum genes involved in the tricarboxylic acid cycle and glyoxylate bypass

2008

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The effect of different carbon sources on the expression of tricarboxylic acid (TCA) cycle genes, along with glyoxylate bypass genes, in Corynebacterium glutamicum was determined. All TCA cycle genes were coordinately expressed in medium containing acetate. Growth in the presence of acetate gave rise to abundant expression of most TCA cycle genes, with the level of gltA transcript being the highest. However, when the cells entered the stationary phase triggered by acetate exhaustion, all genes were repressed, except sucCD and mdhB, which were slightly induced. Acetate withdrawal from the growth medium during the exponential phase also led to rapid repression of most TCA cycle genes and a corresponding twofold increase in the expression of sucCD, which were strongly induced by citrate and succinate. In addition, glucose depletion during the stationary phase led to a corresponding 8-20-fold induction of the sucCD, aceA and aceB genes. Addition of glucose to acetate medium resulted in about 10-fold induction of sucCD. The strong dependence of TCA cycle sucCD and glyoxylate bypass aceA and aceB expression on carbon source availability was confirmed and the regulatory system will be studied precisely. INTRODUCTIONCorynebacterium glutamicum, a non-pathogenic, facultative anaerobic Gram-positive soil bacterium, is widely used in the industrial production of numerous metabolites, including amino acids and organic acids (Kinoshita et al., 1957;Liebl, 2005;Nishimura et al., 2007). In contrast to closely related, medically important pathogenic species, such as Corynebacterium diphtheriae and Mycobacterium tuberculosis, C. glutamicum is generally recognized as a nonhazardous organism (Dover et al., 2004;Funke et al., 1997). Furthermore, this organism has gained increasing interest as a suitable model organism for high-G+C-content Grampositive bacteria in general and for Corynebacterineae, a suborder of the Actinomycetes, in particular.One of the central metabolic pathways in C. glutamicum and in other aerobic bacteria is the tricarboxylic acid (TCA) cycle, which is responsible for the complete oxidation of acetyl-CoA derived from various substrates and for the provision of precursors for amino acid biosynthesis. TCA cycle intermediates are commonly used by other metabolic reactions in a wide variety of cell types. Due to the commercial importance of the amino acids and organic acids produced by C. glutamicum, the control of TCA cycle enzyme activities has been the subject of intensive studies, and the phenotypes of mutants affecting TCA cycle genes have been analysed (Eikmanns et al., 1994(Eikmanns et al., , 1995Molenaar et al., 1998Molenaar et al., , 2000Usuda et al., 1996;Wittmann & De Graaf, 2005). However, limited work has been devoted to the regulation of the expression of C. glutamicum TCA cycle genes in response to different growth phases and carbon sources. Recently we have reported the transcription of C. glutamicum genes involved in the TCA cycle and glyoxylate bypass (Han et al., 2008). In fact, aspects of the re...

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“…This type of peptidoglycan is found only in members of three other genera of this suborder, namely Corynebacterium, Dietzia and Turicella. While phylogenetic data suggested that strain OFN S31 T was related to the genus Mycobacterium, the fact that the strain lacks mycolic acids indicates that it is related to C. amycolatum, C. kroppenstedtii and T. otitidis (Liebl, 2006) (Table 2). …”

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confidence: 99%

Hoyosella altamirensis gen. nov., sp. nov., a new member of the order Actinomycetales isolated from a cave biofilm

Jurado

Kroppenstedt

Sáiz‐Jiménez

et al. 2009

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLO

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Corynebacterium--Nonmedical

Cited by 39 publications

References 179 publications

Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R

Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R

Effect of carbon source availability and growth phase on expression of Corynebacterium glutamicum genes involved in the tricarboxylic acid cycle and glyoxylate bypass

Hoyosella altamirensis gen. nov., sp. nov., a new member of the order Actinomycetales isolated from a cave biofilm

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