Corynebacterium parvum versus tetracycline as pleural sclerosing agents in rabbits

Vargas, Francisco Suso; Wang, N.-S.; Teixeira, Lisete R.; Carmo, Alipio O.; Silva, L. M. M. F.; Light, Richard W.

doi:10.1183/09031936.95.08122174

Cited by 11 publications

(10 citation statements)

References 23 publications

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“…They detected limited inflammation in only one rabbit [18]. Another study of Vargas et al, conducted to compare the effects of pleurodesis initiated by Corynebacterium parvum and tetracycline in rabbits, showed that 4 and 8 mg of Corynebacterium parvum did not cause any fibrogenic effects [19]. In our study, we achieved a powerful and successful outcome with the use of H 2 O 2 , similar to that achieved through talc pleurodesis.…”

Section: Discussionsupporting

confidence: 73%

Thoracic surgery Comparison of the effects of pleurodesis induced by talc and hydrogen peroxide

Eser¹,

Günay²,

Kürkçüoğlu³

2013

kitp

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Section: Discussionsupporting

confidence: 73%

Thoracic surgery Comparison of the effects of pleurodesis induced by talc and hydrogen peroxide

Eser¹,

Günay²,

Kürkçüoğlu³

2013

kitp

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“…Bleomycin appears to be effective in producing a pleurodesis in patients with malignant pleural effusion [11,19] but not in normal rabbits [20,21]. The intrapleural injection of dried Corynebacterium parvum is effective in controlling malignant pleural effusions [23] but does not produce a pleurodesis in rabbits [22]. It is possible that the presence of the malignancy alters the pleural responsiveness so that a pleurodesis results only when tumor cells are present with these two agents.…”

Section: Discussionmentioning

confidence: 99%

Comparison of mitoxantrone and tetracycline as pleural sclerosing agents in rabbits

Light¹,

Wang

Despars³

et al. 1996

Lung

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Bleomycin is the antineoplastic agent used most commonly for the treatment of malignant pleural effusion. It is absorbed rapidly from the pleural space and does not elicit pleurodesis in the normal rabbit pleura. Mitoxantrone is a new antineoplastic that differs from bleomycin in that it binds to membranes. Accordingly it might remain in the pleural space for a longer period and produce a pleurodesis. The objective of this project was to determine whether mitoxantrone is an effective sclerosant in an experimental model in rabbits. The following medications were instilled intrapleurally in anesthetized male rabbits: 35 mg/kg tetracycline or 0.5, 1.0, or 2.0 mg/kg mitoxantrone. The animals were killed at 28 days and the pleural spaces assessed grossly for pleurodesis and microscopically for fibrosis and inflammation. The mean degree of gross pleurodesis did not differ significantly in the rabbits that received tetracycline (3.8 +/- 0.4) and in the rabbits that received 2 mg/kg mitoxantrone (3.2 +/- 1.3). The degree of pleural and lung inflammation was significantly greater after mitoxantrone than after tetracycline, both ipsilaterally and contralaterally. The mortality after the highest dose of mitoxantrone was 50%. From this study we conclude that the intrapleural administration of mitoxantrone in rabbits can produce a pleurodesis. The histologic picture after mitoxantrone administration differs markedly from that after tetracycline injection. After mitoxantrone injection there are many more inflammatory cells present on the side that received the injection, and there is much more fibrosis and inflammation in the contralateral pleura and lung. The model of pleural fibrosis following intrapleural mitoxantrone may be useful for the study of pleural fibrosis.

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“…A trend for a higher complete response rate in the tetracycline arm might be related to the higher doses used (1.5 g), as suggested by its mechanism of action. In an experimental model, intrapleural tetracycline acts in a dose-dependent way, stimulating mesothelial cells to release a growth-factor-like activity for fibroblasts that induces pleural fibrosis [16,17]. By contrast, the injection of bleomycin was ineffective in creating pleural fibrosis in rabbits with normal pleura, thus suggesting a possible antineoplastic effect [18].…”

Section: Discussionmentioning

confidence: 99%

Pleurodesis in malignant pleural effusions: a randomized study of tetracycline versus bleomycin

Martínez‐Moragón

Aparicio²,

Rogado³

et al. 1997

Eur Respir J

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Malignant pleural effusions are commonly managed with tube thoracostomy drainage followed by chemical pleurodesis. Both tetracycline and bleomycin have been shown to be effective for intrapleural instillation, although neither agent has definitively proved advantages over the other. The aim of the present study was to compare these two agents in terms of response rate and toxicity profile.A prospective, randomized trial was carried out in a single centre. Between May 1993 and January 1996, 62 evaluable patients with proved malignant pleural effusion were allocated to receive either intrapleural tetracycline (1.5 g) or bleomycin (60 mg) after the same drainage procedure. Demographic, clinical and fluid parameter data were comparable in both groups. Response was evaluated at 1, 3 and 6 months after pleurodesis.Mean survival and time to relapse did not differ between the two groups. No statistically significant differences were found in terms of efficacy at each evaluation time. Overall, 16 (52%) and 20 (64%) patients had a recurrence of pleural effusion during follow-up in the tetracycline and bleomycin arms, respectively. Fever was most common in bleomycin-treated patients (p=0.024) while pain was most frequent in the tetracycline arm (nonsignificant).Since no study agent was superior to the other in this trial, we suggest that economic costs, drug availability and medical skill should be considered in the choice of a sclerosing agent.

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Corynebacterium parvum versus tetracycline as pleural sclerosing agents in rabbits

Cited by 11 publications

References 23 publications

Thoracic surgery Comparison of the effects of pleurodesis induced by talc and hydrogen peroxide

Thoracic surgery Comparison of the effects of pleurodesis induced by talc and hydrogen peroxide

Comparison of mitoxantrone and tetracycline as pleural sclerosing agents in rabbits

Pleurodesis in malignant pleural effusions: a randomized study of tetracycline versus bleomycin

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