Corynebacterium propinquum Associated With Acute, Nongonococcal Urethritis

Abdolrasouli, Alireza; Roushan, Azita

doi:10.1097/olq.0000000000000027

Cited by 19 publications

(10 citation statements)

References 26 publications

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“…The next closest relative of C34 is Corynebacterium propinquum (Supporting Information Fig. S1), a pathogen known in humans (Díez-Aguilar et al, 2013), that can be sexually transmitted (Abdolrasouli & Roushan, 2013). C34 also clusters closely with the pathogenic C. pseudodiphtheriticum (Díez-Aguilar et al, 2013) and more distantly with the causative agent of diphtheria (C. diphtheriae) and the pathogenic C. pseudotuberculosis (Supporting Information, Fig.…”

Section: Resultsmentioning

confidence: 99%

Experimental evidence of a sexually transmitted infection in a wild vertebrate, the black-legged kittiwake (Rissa tridactyla)

Dongen

White

Brandl

et al. 2019

Biological Journal of the Linnean Society

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Sexually transmitted infections (STIs) in animals may have profound eco-evolutionary consequences, yet experimental studies of the sexual transmission of pathogens in wild populations are lacking. Here to identify sexually transmitted bacteria, we experimentally manipulated ejaculate transfer in black-legged kittiwakes (Rissa tridactyla) by blocking insemination after pairs had commenced copulating. We found that a Corynebacterium pathogenic strain was cleared from the cloaca of females five times more frequently in the experimental group, indicating it had been sexually transferred. A typical feature of STIs is that they reduce fertility, and in our kittiwake population, infected females suffered significantly higher hatching failure than uninfected females. Nevertheless, infected females achieved the same reproductive success as uninfected females by laying earlier and producing more eggs, suggesting reproductive compensation, a common strategy adopted by infected animals and plants. Our results provide new insights into the fitness consequences of STIs in a wild species and may stimulate further research on their evolutionary implications.

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Section: Resultsmentioning

confidence: 99%

Experimental evidence of a sexually transmitted infection in a wild vertebrate, the black-legged kittiwake (Rissa tridactyla)

Dongen

White

Brandl

et al. 2019

Biological Journal of the Linnean Society

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“…It has also been reported as the causative agent in a handful of respiratory tract infections worldwide [6–8]. It has also been reported to cause acute nongonococcal urethritis in one patient from Iran [11]. To our knowledge, this is the first report of Corynebacterium propinquum causing prosthetic valve endocarditis.…”

Section: Discussionmentioning

confidence: 80%

Corynebacterium propinquum: A Rare Cause of Prosthetic Valve Endocarditis

Jangda

Upadhyay

Bagheri

et al. 2016

Case Reports in Medicine

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Nondiphtheria Corynebacterium species are often dismissed as culture contaminants, but they have recently become increasingly recognized as pathologic organisms. We present the case of a 48-year-old male patient on chronic prednisone therapy for rheumatoid arthritis with a history of mitral valve replacement with prosthetic valve. He presented with fever, dizziness, dyspnea on exertion, intermittent chest pain, and palpitations. Transesophageal echocardiography revealed two medium-sized densities along the inner aspect of the sewing ring and one larger density along the atrial surface of the sewing ring consistent with vegetation. Two separate blood cultures grew Corynebacterium propinquum, which were sensitive to ceftriaxone but highly resistant to vancomycin and daptomycin. The patient completed a course of ceftriaxone and repeat TEE study and after 6 weeks demonstrated near complete resolution of the vegetation. To our knowledge, this case represents the first in the literature of Corynebacterium propinquum causing prosthetic valve endocarditis. The ability of these organisms to cause deep-seated systemic infections should be recognized, especially in immune-compromised patients.

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“…propinquum (formerly called CDC coryneform group ANF-3) is considered a member of the normal oropharynx and skin flora. It has occasionally been involved in opportunistic infections such as respiratory infections 6-8 , bacteremia 9 , endocarditis 10 , pleural effusion 11 , osteoarticular infections 12,13 , trichomycosis axillaris 14 , non-gonococcal urethritis 15 , and contact lens related keratitis 16 . Previous hospitalization, immunosuppression, chronic corticosteroid therapy, previous broad-spectrum antibiotic therapy, and underlying respiratory disease are the risk factors shared in most of the published cases of C. propinquum infections.…”

Section: Discussionmentioning

confidence: 99%

Corynebacterium propinquum bronchopneumonia in a child with ataxia telangiectasia

et al. 2016

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Nondiphtherial Corynebacterium species isolated from clinical specimens are usually considered as contaminants by many clinicians when reported by microbiologists. However, an increasing number of studies have confirmed the importance of Corynebacterium spp. in the etiology of a variety of infectious processes. In this report, we present a case of bronchopneumonia caused by Corynebacterium propinquum. The infection occurred in a seven-year-old child who had a history of immunosuppression due to ataxia telangiectasia. The purulent sputum of the patient yielded a large number of polymorphonuclear leucocytes with abundant gram-positive coryneform bacilli in gram staining and pure growth of coryneform bacteria in culture. Definitive identification as C. propinquum was made by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and 16S rRNA gene sequencing. C. propinquum should be recognized as a potential pathogen and included in the etiologic diagnostic algorithm, particularly in patients with immunosuppressive conditions.

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Corynebacterium propinquum Associated With Acute, Nongonococcal Urethritis

Cited by 19 publications

References 26 publications

Experimental evidence of a sexually transmitted infection in a wild vertebrate, the black-legged kittiwake (Rissa tridactyla)

Experimental evidence of a sexually transmitted infection in a wild vertebrate, the black-legged kittiwake (Rissa tridactyla)

Corynebacterium propinquum: A Rare Cause of Prosthetic Valve Endocarditis

Corynebacterium propinquum bronchopneumonia in a child with ataxia telangiectasia

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