Corynebacterium pseudotuberculosis Pneumonia in a Veterinary Student Infected During Laboratory Work

Heggelund, Lars; Gaustad, Peter; Håvelsrud, Othilde Elise; Blom, Jochen; Borgen, Lars; Sundset, Arve; Sørum, Henning; Frøland, Stig S.

doi:10.1093/ofid/ofv053

Cited by 30 publications

(22 citation statements)

References 31 publications

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“…Similar cluster aggregation was observed for a different biovar of C. pseudotuberculosis based on the whole genome analysis performed by Heggelund et al . ().…”

Section: Discussionmentioning

confidence: 97%

Identification ofCorynebacterium pseudotuberculosisisolated from muscular abscesses in two horses: First report in Mexico

Muñoz-Bucio¹,

Cortés-Pérez²,

Arellano-Reynoso³

et al. 2016

Equine Veterinary Education

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Summary Two Quarter Horse stallions from the same region in Mexico presented with pectoral abscesses and lameness. Exudate samples were taken from drained muscular abscesses and Corynebacterium pseudotuberculosis, identified by bacteriological techniques and multiplex polymerase chain reaction, was obtained in a pure isolation culture from both samples. The sequences of a hypervariable region of the rpoB gene showed 100% and 99% identity to C. pseudotuberculosis 316 biovar equi (CP003077.1) isolated from a horse. Both strains' sequences were located in the same phylogenetic cluster as other biovar equi strain sequences obtained from GenBank. Both horses responded satisfactorily to treatment, which included surgical procedures and wound management. These study cases proved the infection of Mexican horses with C. pseudotuberculosis; however, the prevalence of this pathogen remains unknown.

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“…Similar cluster aggregation was observed for a different biovar of C. pseudotuberculosis based on the whole genome analysis performed by Heggelund et al . ().…”

Section: Discussionmentioning

confidence: 97%

Identification ofCorynebacterium pseudotuberculosisisolated from muscular abscesses in two horses: First report in Mexico

Muñoz-Bucio¹,

Cortés-Pérez²,

Arellano-Reynoso³

et al. 2016

Equine Veterinary Education

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“…in veterinary students [23–26]. One case of infection by Corynebacterium pseudotuberculosis of laboratory origin has been reported [21] and also one case of West Nile virus after performing a necropsy on an infected horse [68]. …”

Section: Resultsmentioning

confidence: 99%

“…The consulted literature only described one case of zoonosis in veterinary students originated in a microbiology laboratory [21] and another in a necropsy room [68]. These findings suggest that biosafety protocols are easier to develop in academic facilities than in external farms.…”

Section: Discussionmentioning

confidence: 99%

Zoonoses in Veterinary Students: A Systematic Review of the Literature

et al. 2017

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BackgroundVeterinary students face diverse potential sources of zoonotic pathogens since the first years of their academic degree. Such sources include different animal species and pathologic materials which are used at university facilities as well as commercial clinics, farms and other external facilities.ObjectivesThe present study utilizes a systematic review of the literature to identify zoonoses described in veterinary students.Data sourcesWeb of Science and PubMed.ResultsOf the 1,254 titles produced by the bibliographic search, 62 were included in this review. Whereas 28 of these articles (45.2%) described individual cases or outbreaks, the remaining 34 (54.8%) reported serological results. The zoonotic etiological agents described were bacteria, in 39 studies (62.9%), parasites, in 12 works (19.4%), virus, in 9 studies (14.5%) and fungi, in 2 (3.2%) of the selected articles. The selected literature included references from 24 different countries and covered the time period of the last 55 years.LimitationsThe fact that common cases of disease or cases of little clinical importance without collective repercussions are not usually published in peer-reviewed journals limits the possibility to reach conclusions from a quantitative point of view. Furthermore, most of the selected works (66.1%) refer to European or North American countries, and thus, the number of cases due to pathogens which could appear more frequently in non-occidental countries might be underestimated.Conclusions/implicationsThe results of the present systematic review highlight the need of including training in zoonotic diseases since the first years of Veterinary Science degrees, especially focusing on biosecurity measures (hygienic measures and the utilization of the personal protective equipment), as a way of protecting students, and on monitoring programs, so as to adequately advise affected students or students suspicious of enduring zoonoses.

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“…Further, C. ulcerans infections in humans have emerged recently and usually involve close contacts with animals, mainly domestic cats and dogs (5, 6). C. pseudotuberculosis is primarily a veterinary pathogen that infects ungulates such as sheep and goats (7), and the rare human infections with C. pseudotuberculosis are associated with occupational risk factors (8–10). Although rarely reported, C. diphtheriae can also infect animals such as cats, cows and horses (11–13).…”

Section: Introductionmentioning

confidence: 99%

“…However, phenotypic methods require strain culture and isolation and are slow. In addition, the biochemical identification of C. pseudotuberculosis and its differentiation from other corynebacteria, especially C. ulcerans , can be difficult (10). Further, these methods cannot determine the toxigenic status of strains.…”

Section: Introductionmentioning

confidence: 99%

Optimization and validation of a quadruplex real-time PCR assay for the diagnosis of diphtheria

Badell

Guillot

Tulliez

et al. 2019

Preprint

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Corynebacterium pseudotuberculosis Pneumonia in a Veterinary Student Infected During Laboratory Work

Cited by 30 publications

References 31 publications

Identification ofCorynebacterium pseudotuberculosisisolated from muscular abscesses in two horses: First report in Mexico

Identification ofCorynebacterium pseudotuberculosisisolated from muscular abscesses in two horses: First report in Mexico

Zoonoses in Veterinary Students: A Systematic Review of the Literature

Optimization and validation of a quadruplex real-time PCR assay for the diagnosis of diphtheria

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