Cardiac implantable electronic device infection (CIEDI) in the context of corynebacterial bloodstream infection (BSI) remains poorly understood. From 2012-2023 at Mayo Clinic, 4 of 12 patients with corynebacterial BSI had CIEDI: 1 patient was diagnosed during a relapsing BSI episode. Undefined source, persistent BSI, and presence of a prosthetic cardiac valve were common characteristics.