Cosensitization to orange seed and cashew nut

O’Sullivan, Michael; Somerville, C. L.

doi:10.1016/j.anai.2011.06.003

Cited by 20 publications

(14 citation statements)

References 5 publications

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“…These four cases, which had reacted with symptoms to citrus seeds, were IgE positive to lemon seeds and had a positive prick-to-prick skin test reaction. These findings are in line with earlier observations (3)(4)(5). Also, the notion that our cases were clinically tolerant to, and less sensitized to, lemon and orange fruit than the respective seeds (Table 1) stresses the importance of seeds in the cross-reactivity to nuts, as suggested by others (3)(4)(5)7).…”

Section: Ige To Novel Citrus Seed Allergens Among Cashew-allergic Chisupporting

confidence: 94%

“…These findings are in line with earlier observations (3)(4)(5). Also, the notion that our cases were clinically tolerant to, and less sensitized to, lemon and orange fruit than the respective seeds (Table 1) stresses the importance of seeds in the cross-reactivity to nuts, as suggested by others (3)(4)(5)7). Therefore, it might be of importance not only to consider the, perhaps, more obvious risk of cross-reactivity between homologous proteins from different nuts (8,9) when diagnosing and informing nut-allergic patients, but also to consider including potentially cross-reacting fruit seeds, especially because seed proteins can be hidden allergens that may leak from seeds during food processing, but not be visible in the food ingested.…”

Section: Ige To Novel Citrus Seed Allergens Among Cashew-allergic Chisupporting

confidence: 94%

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IgE to novel citrus seed allergens among cashew‐allergic children

Brändström

Lilja

Nilsson

et al. 2016

Pediatric Allergy Immunology

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Section: Ige To Novel Citrus Seed Allergens Among Cashew-allergic Chisupporting

confidence: 94%

Section: Ige To Novel Citrus Seed Allergens Among Cashew-allergic Chisupporting

confidence: 94%

IgE to novel citrus seed allergens among cashew‐allergic children

Brändström

Lilja

Nilsson

et al. 2016

Pediatric Allergy Immunology

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“…A high degree of serological cross-reactivity has been established between cashew nut and pistachio (Pis v 1, Pis v 2 and Pis v 3) by sIgE-inhibition tests. This may be explained by the highly conserved primary and three-dimensional structure of these allergen homologue pairs, present in both cashew nut and pistachio (18)(19)(20)(21)(22) (2,3,19,22,(25)(26)(27). Sensitization against cashew nut allergy seems to be a primary sensitization rather than a cross-reaction between cashew nuts and pollens.…”

Section: Allergensmentioning

confidence: 99%

Systematic review on cashew nut allergy

Valk

Dubois

Wijk

et al. 2014

Allergy

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Recent studies on cashew nut allergy suggest that the prevalence of cashew nut allergy is increasing. Cashew nut consumption by allergic patients can cause severe reactions, including anaphylaxis. This review summarizes current knowledge on cashew nut allergy to facilitate timely clinical recognition and to promote awareness of this emerging food allergy amongst clinicians. The goal of this study is to present a systematic review focused on the clinical aspects of allergy to cashew nut including the characteristics of cashew nut, the prevalence, allergenic components, cross-reactivity, diagnosis and management of cashew nut allergy. The literature search yielded 255 articles of which 40 met our selection criteria and were considered to be relevant for this review. The 40 articles included one prospective study, six retrospective studies and seven case reports. The remaining 26 papers were not directly related to cashew nut allergy. The literature suggests that the prevalence of cashew nut allergy is increasing, although the level of evidence for this is low. A minimal amount of cashew nut allergen may cause a severe allergic reaction, suggesting high potency comparable with other tree nuts and peanuts. Cashew allergy is clearly an underestimated important healthcare problem, especially in children.Although peanut allergy has been on the increase for two decades or more, studies indicate that cashew nut is also becoming an important food allergen (1, 2). The rapid increase in consumption of cashew nuts and the change in eating and cooking habits may be responsible for the increasing significance of cashew nut allergy (2).In this paper, we summarize the relevant information available on epidemiology, allergen components, clinical features, diagnosis, clinical and in vitro cross-sensitization and management of cashew nut allergy. Data sources and literature searchIn our search, we adhered to the methods and procedures of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines for reporting this systematic review, excluding irrelevant items. Registration number in PROSPERO is CRD42013004047.We used Ovid MEDLINE and EMBASE databases to identify relevant articles using the string: (Anacardi* sensitiv*) OR allerg*): de, ab, ti for EMBASE. We also checked references to relevant articles ('snowballing').We aimed to include studies focused on the clinical aspects of cashew nut allergy. We considered only studies in English. There was no restriction on publication date. Mouse model studies were excluded. Initially, all articles on cashew nut allergy or on cashew nuts were included. Thereafter articles on contact dermatitis, genetics, product labelling, poisoning, detection methods and possible medicinal effects of cashew plants were excluded. Forty of 255 articles found with the literature search (244 articles) and by 'snowballing (11 articles) were considered relevant for the review. Of these 40 articles, one article was a prospective study and six articles were retrospective stu...

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“…Evidence of immunological cross-reactivity between homologous storage proteins in nuts, seeds and legumes is well-known. In addition, there are several reports also for allergy symptoms among peanut and tree nut allergic individuals caused by cross-reactions to storage proteins from fruit and plant seeds [ 14 – 20 ]. In this study, this nut and fruit seed cross-reactivity is further highlighted by the findings from patients reporting allergy to both peanut and kiwi.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, this nut and fruit seed cross-reactivity is further highlighted by the findings from patients reporting allergy to both peanut and kiwi. Storage proteins have stable IgE-binding epitopes that often are resistant to both heating and gastrointestinal processing [ 5 , 14 ]. Seeds from fruits can be ingested both intentionally and accidentally, as seed storage proteins can leak during food processing leading to unintentional contamination of for example fruit juices [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

High frequency of IgE sensitization towards kiwi seed storage proteins among peanut allergic individuals also reporting allergy to kiwi

et al. 2017

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BackgroundIgE sensitization to storage proteins from nuts and seed is often related to severe allergic symptoms. There is a risk of immunological IgE cross-reactivity between storage proteins from different species. The potential clinical implication of such cross-reactivity is that allergens other than the known sensitizer can cause allergic symptoms. Previous studies have suggested that kiwi seed storage proteins may constitute hidden food allergens causing cross-reactive IgE-binding with peanut and other tree nut homologs, thereby mediating a potential risk of causing allergy symptoms among peanut ant tree nut allergic individuals. The objective of this study was to investigate the degree of sensitization towards kiwi fruit seed storage proteins in a cohort of peanut allergic individuals.MethodsA cohort of 59 adolescents and adults with peanut allergy was studied, and self reported allergies to a number of additional foods were collected. Quantitative IgE measurements to seed storage proteins from kiwi and peanut were performed.ResultsIn the cohort, 23 out of the 59 individuals were reporting kiwi fruit allergy (39%). The frequency of IgE sensitization to kiwi fruit and to any kiwi seed storage protein was higher among peanut allergic individuals also reporting kiwi fruit allergy (P = 0.0001 and P = 0.01). A positive relationship was found between IgE levels to 11S globulin (r = 0.65) and 7S globulin (r = 0.48) allergens from kiwi and peanut, but IgE levels to 2S albumin homologs did not correlate. Patients reporting kiwi fruit allergy also reported allergy to hazelnut (P = 0.015), soy (P < 0.0001), pea (P = 0.0002) and almond (P = 0.016) to a higher extent than peanut allergic individuals without kiwi allergy.ConclusionsThirty-nine percent of the peanut allergic patients in this cohort also reported kiwi fruit allergy, they displayed a higher degree of sensitization to kiwi storage proteins from both kiwi and peanut, and they also reported a higher extent of allergy to other nuts and legumes. On the molecular level, there was a correlation between IgE levels to 11S and 7S storage proteins from kiwi and peanut. Taken together, reported symptoms and serological findings to kiwi in this cohort of patients with concurrent allergy to peanut and kiwi fruit, could be explained by a combination of cross-reactivity between the 11S and 7S globulins and co-sensitization to the 2S albumin Act d 13.

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Cosensitization to orange seed and cashew nut

Cited by 20 publications

References 5 publications

IgE to novel citrus seed allergens among cashew‐allergic children

IgE to novel citrus seed allergens among cashew‐allergic children

Systematic review on cashew nut allergy

High frequency of IgE sensitization towards kiwi seed storage proteins among peanut allergic individuals also reporting allergy to kiwi

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