Cosmeceutical Therapy: Engaging the Repercussions of UVR Photoaging on the Skin’s Circadian Rhythm

Mahendra, Camille Keisha; Ser, Hooi‐Leng; Pusparajah, Priyia; Htar, Thet Thet; Chuah, Lay Hong; Yap, Wei Hsum; Tang, Yin Quan; Zengin, Gökhan; Tang, Siah Ying; Lee, Wai Leng; Liew, Kai Bin; Ming, Long Chiau; Goh, Bey Hing

doi:10.3390/ijms23052884

Cited by 9 publications

(4 citation statements)

References 154 publications

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“…In addition to the four theories mentioned in this article, genetical factors, DNA repair and stability, cellular senescence and telomeres, mitochondria, apoptosis, estrogen deficiency, circadian rhythms, neuroendocrine, diseases, physical activity, stress, and other environmental factors (e.g., diet, pollution and smoking) are also important in the field of skin aging, and have been studied in animal and experimental studies on cell cultures [ 36 , 37 , 38 , 39 , 40 ]. Additionally, skin as a stress sensor, modulates homeostasis via the neuroendocrine and immune systems, and signaling molecules.…”

Section: Mechanisms Of Skin Aging Processesmentioning

confidence: 99%

Research Progress on Skin Aging and Active Ingredients

Wan

et al. 2023

Molecules

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With the advancement of living standards in modern society and the emergence of an aging population, an increasing number of people are becoming interested in the topic of aging and anti-aging. An important feature of aging is skin aging, and women are particularly concerned about skin aging. In the field of cosmetics, the market share of anti-aging products is increasing year by year. This article reviews the research and development progress of skin aging and related active compounds both domestically and internationally in recent years. The results show that, in terms of the research on skin aging, the popular theories mainly include free radicals and oxidative stress theory, inflammation theory, photoaging theory, and nonenzymatic glycosyl chemistry theory. In terms of research on the active ingredients with anti-aging activities in the skin, there are numerous reports on related products in clinical studies on human subjects, animal experiments, and experimental studies on cell cultures, with a variety of types. Most of the compounds against skin aging are sourced from natural products and their action mechanisms are mainly related to scavenging oxygen free radicals and enhancing antioxidant defenses. This review provides important references for the future research of skin aging and the development of related products. Although there is a great progress in skin aging including related active ingredients, ideal compounds or products are still lacking and need to be further validated. New mechanisms of skin aging, new active ingredients sourced from natural and artificial products, and new pharmaceutical forms including further clinical validations should be further investigated in the future.

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Section: Mechanisms Of Skin Aging Processesmentioning

confidence: 99%

Research Progress on Skin Aging and Active Ingredients

Wan

et al. 2023

Molecules

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“…The circadian rhythm synchronizes each type of skin cell with the natural rhythm of the human body. (14,50) A decline in circadian rhythm and gene expression that can contribute to oxidative stress through chronic or increased accumulation of ROS is associated with aging. (1,51) Important mechanisms of the skin in maintaining homeostasis include the regulation of oxidative stress mechanisms.…”

Section: Melatonin and Skin Agingmentioning

confidence: 99%

“…(12,13) Evident symptoms may be seen in the formation of irregular pigmentation and wrinkles, and in the reduction in skin elasticity. (14,15) Ultraviolet (UV) activates and inhibits various signaling pathways in the dermis and epidermis, leading to a decrease of the extracellular matrix (ECM) content and provoking an uneven skin structure or even collapse of the skin. (11) Melatonin is starting to be considered as a therapeutic option in photoprotection and skin aging due to its antioxidant effects, indicating its critical role in preventing damage due to deoxyribonucleic acid (DNA) repair mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Protective role of melatonin in ultraviolet radiation- induced oxidative stress in human skin photoaging

Suyanto,

Widianti

2023

Univ Med

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The ultraviolet radiation of the sun that reaches the earth is made up of ultraviolet A (95%) and ultraviolet B (5%). Exposure to ultraviolet radiation (UVR) is the main factor in photoaging. Chronic exposure to sunlight acts as an environmental stressor, leading to oxidative damage or stress. Oxidative damage stimulates the accumulation of free radicals, such as reactive oxygen species (ROS) or reactive nitrogen species (RNS) that are responsible for premature skin aging. Photoaged skin is characterized externally by irregular pigmentation, wrinkles, and reduced skin elasticity, and internally by the breakdown of dermal collagen and elastin. Free radicals can be scavenged and the skin can be protected from further oxidative damage by antioxidants. Melatonin is a hormone produced mainly by the pineal gland, as well as many other organs, including the skin. One of the functions of melatonin is exerted by the antioxidative melatoninergic system to prevent ultraviolet (UV)-induced skin photoaging. The aim of this review was to study the protective effect of melatonin on skin photoaging resulting from UVR exposure. The references were tracked using various databases, such as Google Scholar and PubMed with regard to publications in English for the last 5 years (2019-2023). Melatonin inhibits UVR-induced aging in multiple ways, such as protecting skin cells, binding free radicals, accelerating the activity of antioxidant enzymes, preventing increased mitochondrial membrane permeability, and assisting electron transport efficiency in the mitochondrial respiratory chain. Exogenous application of melatonin is usually by the oral route, but for localized effects on the skin, topical administration is recommended, with consideration of preparations with a better half-life and bioavailability. Understanding the protective antioxidant function of melatonin in UV-induced skin photoaging helps to optimize its application. The protective properties of melatonin against UVR-oxidative stress-induced photoaging will be further explored in this review.

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“…On the other hand, UVB, which has a shorter wavelength of 280-320 nm, can only penetrate up to the epidermal layer of our skin [27]. Regardless of their characteristics, overexposure to both UVR causes dysregulation in the skin's circadian rhythm and activates the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) [28][29][30]. The overproduction of both ROS and RNS then quickly overwhelms the skin's antioxidant defense system, causing nitrosative and oxidative stress in the skin [29].…”

Section: Photoprotective Skin Whitening and Skin Repair Cosmeceutical...mentioning

confidence: 99%

The Prospects of Swietenia macrophylla King in Skin Care

et al. 2022

Self Cite

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The importance of cosmetics in our lives is immeasurable. Covering items from daily personal hygienic products to skincare, it has become essential to consumers that the items that they use are safe and effective. Since natural products are from natural sources, and therefore considered “natural” and “green” in the public’s eyes, the rise in demand for such products is not surprising. Even so, factoring in the need to remain on trend and innovative, cosmetic companies are on a constant search for new ingredients and inventive new formulations. Based on numerous literature, the seed of Swietenia macrophylla has been shown to possess several potential “cosmetic-worthy” bioproperties, such as skin whitening, photoprotective, antioxidant, antimicrobial, etc. These properties are vital in the cosmetic business, as they ultimately contribute to the “ageless” beauty that many consumers yearn for. Therefore, with further refinement and research, these active phytocompounds may be a great contribution to the cosmetic field in the near future.

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Cosmeceutical Therapy: Engaging the Repercussions of UVR Photoaging on the Skin’s Circadian Rhythm

Cited by 9 publications

References 154 publications

Research Progress on Skin Aging and Active Ingredients

Research Progress on Skin Aging and Active Ingredients

Protective role of melatonin in ultraviolet radiation- induced oxidative stress in human skin photoaging

The Prospects of Swietenia macrophylla King in Skin Care

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