Cosmetic components causing contact urticaria: a review and update

Verhulst, Lien; Goossens, An

doi:10.1111/cod.12679

Cited by 51 publications

(36 citation statements)

References 144 publications

(99 reference statements)

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“…Likewise, purely lipid‐based vehicles can lead to an impaired skin barrier and facilitate deeper penetration of allergens into the skin. The same potential risk has to be observed for a number of natural – partly insufficiently purified – ingredients such as bisabolol, oat extract or lanolin when used in patients with damaged skin .…”

Section: Discussionmentioning

confidence: 95%

Diagnosis and treatment of xerosis cutis – a position paper

Augustin

Wilsmann‐Theis²,

Körber³

et al. 2019

J Deutsche Derma Gesell

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Summary Background and rationale Xerosis cutis (also referred to as xeroderma, dry skin, asteatosis) affects more than 10 million individuals in Germany. It is among the most common dermatological diagnoses and a cardinal symptom of many dermatological, internal and neurological diseases. Even though it has been established that basic skin care plays a significant role in the management of patients with xerosis cutis, there are as yet no evidence‐based algorithms for diagnosis and treatment. Objective The present position paper provides physicians across all specialties with a practical, symptom‐based approach to the prevention, diagnosis and treatment of xerosis cutis. Methods Within a structured decision‐making process, a panel of experienced dermatologists first defined questions relevant to everyday clinical practice, which were then addressed by a systematic review of the literature. Based on the evidence available as well as expert consensus, diagnostic and treatment algorithms were subsequently developed and agreed upon. Results Xerosis cutis is generally diagnosed on clinical grounds. Possible trigger factors must be avoided, and comorbidities should be adequately and specifically treated. Suitable skin care products should be chosen with a view to improving skin hydration and restoring its barrier function. They should therefore contain both rehydrating and lipid‐replenishing components. The “drier” the skin appears, the greater the lipid content should be (preferably using water‐in‐oil formulations). The choice of ingredients is based on a patient's individual symptoms, such as scaling (e.g., urea), fissures/rhagades (e.g., urea or dexpanthenol), erythema (e.g., licochalcone A) and pruritus (e.g., polidocanol). Other factors to be considered include the site affected and patient age. Ingredients or rather combinations thereof for which there is good clinical evidence should be preferentially used. The best evidence by far is available for urea, whose efficacy in the treatment of xerosis is further enhanced by combining it with other natural moisturizing components and ceramides. The “xerosimeter” is a tool developed in an effort to facilitate patient management and for training purposes. It not only includes practical tools for diagnosis and follow‐up but also a classification of ingredients and a structured treatment algorithm. Conclusion The structured symptom‐ and evidence‐based approach proposed herein contains a road map for diagnosis and treatment of xerosis cutis. It aims to raise awareness in terms of prevention and early treatment of this condition and may thus improve quality of life and prevent potential sequelae.

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Section: Discussionmentioning

confidence: 95%

Diagnosis and treatment of xerosis cutis – a position paper

Augustin

Wilsmann‐Theis²,

Körber³

et al. 2019

J Deutsche Derma Gesell

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“…Verhulst and Goossens recently published a review and update of cosmetic products that have been reported to produce contact urticaria. Causative agents cited included phenoxyethanol, polyaminopropyl biguanide, oxybenzone, menthol, and a number of plant‐derived ingredients including wheat and wheat protein hydrolyzates.…”

Section: Skin Reactivitymentioning

confidence: 99%

Dermatological and environmental toxicological impact of the sunscreen ingredient oxybenzone/benzophenone‐3

DiNardo

Downs²

2017

J of Cosmetic Dermatology

170

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SummaryOxybenzone (Benzophenone-3) is an emerging human and environmental contaminant used in sunscreens and personal care products to help minimize the damaging effects of ultraviolet radiation. The Center for Disease Control fourth national report on human exposure to environmental chemicals demonstrated that approximately 97% of the people tested have oxybenzone present in their urine, and independent scientists have reported various concentrations in waterways and fish worldwide. Oxybenzone can also react with chlorine, producing hazardous by-products that can concentrate in swimming pools and wastewater treatment plants.Moreover, adverse reactions could very well be increased by the closed loop of ingesting fish contaminated with oxybenzone and/or washing the ingredient off our bodies and having it return in drinking water as treatment plants do not effectively remove the chemical as part of their processing protocols. In humans, oxybenzone has been reported to produce contact and photocontact allergy reactions, implemented as a possible endocrine disruptor and has been linked to Hirschsprung's disease. Environmentally, oxybenzone has been shown to produce a variety of toxic reactions in coral and fish ranging from reef bleaching to mortality. Lastly, with the rise in skin cancer rates and the availability of more effective sunscreen actives such as micronized zinc oxide and titanium dioxide, serious doubts about the relative prevention benefit of personal care products containing oxybenzone must be raised and compared with the potential negative health and environmental effects caused by the accumulation of this and other chemicals in the ecosystem.

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“…Skin sensitization is one of the principal concerns related to the use of cosmetics and is usually associated with fragrances, preservatives and hair dyes [21][22][23][24].…”

Section: Skin Sensitizationmentioning

confidence: 99%

“…Skin sensitization is one of the principal concerns related to the use of cosmetics and is usually associated with fragrances, preservatives and hair dyes [21][22][23][24]. Most studies have been done in vivo and a lower percentage on humans using the patch test method, to evaluate potential skin irritation caused by cosmetic ingredients (Figure 3).…”

Section: Skin Sensitizationmentioning

confidence: 99%

Alternative Methods to Animal Testing for the Safety Evaluation of Cosmetic Ingredients: An Overview

Vinardell

Mitjans

2017

Cosmetics

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Abstract:The safety of cosmetics sold in Europe is based on the safety evaluation of each individual ingredient conducted by those responsible for putting the product on the market. However, those substances for which some concern exists with respect to human health (e.g., colorants, preservatives, UV-filters, nanomaterials) are evaluated at the European Commission level by a scientific committee, currently called the Scientific Committee on Consumer Safety (SCCS). According to the Cosmetics Regulation (European Commission, 2009), it is prohibited in the European Union (EU) to market cosmetic products and ingredients that have been tested on animals. However, the results of studies performed before the ban continue to be accepted. In the current study, we evaluated the use of in vitro methods in the dossiers submitted to the SCCS in the period between 2013 and 2016 based on the published reports issued by the scientific committee, which provides a scientific opinion on these dossiers. The results of this evaluation were compared with those of an evaluation conducted four years previously. We found that, despite a slight increase in the number of studies performed in vitro, the majority of studies submitted to the SCCS is still done principally in vivo and correspond to studies performed before the ban.

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Cosmetic components causing contact urticaria: a review and update

Cited by 51 publications

References 144 publications

Diagnosis and treatment of xerosis cutis – a position paper

Diagnosis and treatment of xerosis cutis – a position paper

Dermatological and environmental toxicological impact of the sunscreen ingredient oxybenzone/benzophenone‐3

Alternative Methods to Animal Testing for the Safety Evaluation of Cosmetic Ingredients: An Overview

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