Cosmetotextiles with Gallic Acid: Skin Reservoir Effect

Abstract

The antioxidant gallic acid (GA) has been incorporated into cotton (CO) and polyamide (PA) through two different vehicles, that is, liposomes and mixed micelles, and their respective absorption/desorption processes have been studied. Moreover, in vitro percutaneous absorption tests of different cosmetotextiles have been performed to demonstrate antioxidant penetration within the layers of the skin. When GA was embedded into the cosmetotextiles, it always promoted a reservoir effect that was much more marked than that observed for polyamide. Similar penetration was observed in the textiles treated with GA in mixed micelles or liposomes in such compartments of the skin as the stratum corneum, epidermis, and even the dermis. GA was detected in receptor fluid only when CO was treated with MM. This methodology may be useful in verifying how encapsulated substances incorporated into textile materials penetrate human skin. Indeed, such materials can be considered strategic delivery systems that release a given active compound into the skin at specific doses.

Onion (Allium cepa L.) Skin: A Rich Resource of Biomolecules for the Sustainable Production of Colored Biofunctional Textiles

“…Over the last decade, functional textiles have tremendously evolved thanks to the active cooperation of chemists, physicians, and textile engineers. Indeed, in parallel with the improvement of the already well-established doping and coating procedures, methods based on microencapsulation and grafting technologies have gained increasing popularity in the production process of these products, ensuring enhanced quality of the resulting vehicles [1,3,4,5].…”

“…In recent years, innovative ‘biofunctional’ applications have been receiving attention in the field of cosmetotextile technology, mostly to meet the needs of people with highly sensitive skin. These kinds of material are indeed becoming diffusely appreciated as an innovative vehicle for the local treatment of skin diseases caused by microbial agents [6,7] or sunlight induced photooxidation [5,8].…”

Vehiculation of Active Principles as a Way to Create Smart and Biofunctional Textiles

“…The in vitro percutaneous absorption tests of the different cosmeto-textile structures that were performed (CO and PA with GA vehicularized with liposomes and mixed micelles) have been developed to show, quantitatively, the GA penetration within the layers of the skin [118].…”

“…The structured device remains stable due to the mutual affinity and the physico-chemical interactions, which can break as the fabric rubs the skin, releasing the active agents [117]. Moreover, ethyl hexyl methoxycinnamate (EHMC), was vehicularized using two liposome-based structures: Internal wool lipids (IWL) and phosphatidylcholine (PC) [118]. As in the case of GA, they were applied onto cotton and polyamide fabrics by exhaustion treatments.…”

“…This effect is even more marked for liposome-treated polyamide. Non-treated and PC-treated polyamide fabrics showed significant differences which will influence the mechanism of drug permeation [118].…”