We investigate the power spectra of the CMB temperature and matter density in the running vacuum model (RVM) with the time-dependent cosmological constant of Λ = 3νH 2 + Λ 0 , where H is the Hubble parameter. In this model, dark energy decreases in time and decays to both matter and radiation. By using the Markov chain Monte Carlo method, we constrain the model parameter ν as well as the cosmological observables. Explicitly, we obtain ν ≤ 1.54 × 10 −4 (68% confidence level) in the RVM with the best-fit χ 2 RVM = 13968.8, which is slightly smaller than χ 2 ΛCDM = 13969.8 in the ΛCDM model of ν = 0. * Electronic address: