Cost analysis favours SPECT over PET and CTA for evaluation of coronary artery disease: the SPARC study

Wall, E. E. van der

doi:10.1007/s12471-014-0558-4

Cited by 9 publications

(7 citation statements)

References 13 publications

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“…Of the two techniques, PET has superior sensitivity and resolution but is far more expensive than SPECT as a result of higher instrumentation costs and lower radionuclide availability. − PET and SPECT provide high-quality morphological information but lack anatomical perspective. Accordingly, they are often combined with computed tomography (CT) to produce a more complete biological representation …”

Section: Decay Properties Of Radiometals In Medicinementioning

confidence: 99%

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

2018

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Radiometals possess an exceptional breadth of decay properties and have been applied to medicine with great success for several decades. The majority of current clinical use involves diagnostic procedures, which use either positron-emission tomography (PET) or single-photon imaging to detect anatomic abnormalities that are difficult to visualize using conventional imaging techniques (e.g., MRI and X-ray). The potential of therapeutic radiometals has more recently been realized and relies on ionizing radiation to induce irreversible DNA damage, resulting in cell death. In both cases, radiopharmaceutical development has been largely geared toward the field of oncology; thus, selective tumor targeting is often essential for efficacious drug use. To this end, the rational design of fourcomponent radiopharmaceuticals has become popularized. This Review introduces fundamental concepts of drug design and applications, with particular emphasis on bifunctional chelators (BFCs), which ensure secure consolidation of the radiometal and targeting vector and are integral for optimal drug performance. Also presented are detailed accounts of production, chelation chemistry, and biological use of selected main group and rare earth radiometals.

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Section: Decay Properties Of Radiometals In Medicinementioning

confidence: 99%

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

2018

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“…Van der Wall et al conducted a cost analysis study on diagnostic modalities (including CTA, PET and SPECT) for diagnosis of suspected CAD. This study showed that SPECT is much more cheaper than CTA and PET over 2 years follow-up of suspected CAD patients [33]. However, it is reported that SPECT is signi cantly more expensive compared with stress echocardiography for CAD diagnosis [34].…”

Section: Discussionmentioning

confidence: 74%

The cost effectiveness of Single-Photon Emission-Computed Tomography compared with stress echocardiography for diagnosis of coronary artery disease

Javan‐Noughabi

Rezapour

Hajahmadi

et al. 2021

Preprint

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Early diagnosis of coronary artery disease is very vital for success in treatment of this disease. However, the appropriate diagnostic modality for diagnosis of coronary artery disease is uncertain. Therefore, we conducted this study to compare the cost-effectiveness of Single-Photon Emission-Computed Tomography (SPECT) versus stress echocardiography for diagnosis of coronary artery disease in Iran. A decision tree model was developed to compare the cost-effectiveness of SPECT versus stress echocardiography. This study was conducted in Tehran, capital of Iran, between April 1, 2017, and September 1, 2018. The cost analysis was conducted from a societal perspective and medical direct costs, nonmedical direct costs and indirect costs were estimated. Effectiveness was defined as the accurate detection of coronary artery disease and invasive coronary angiography was used as a gold standard. The incremental cost-effectiveness ratio was defined as an additional cost per correct diagnosis. SPECT was associated with higher costs and lower effectiveness compared with stress echocardiography. Therefore, stress echocardiography is dominant alternative compared to SPECT. The results also indicated that total cost per patient were $970.49 and $781.8 for SPECT and stress echocardiography, respectively. Also, the percent of true positive and true negative responses were %88 and %79 for SPECT and %90 and %92 for stress echocardiography. The results of this study indicate that stress echocardiography is the cost-effective modality in the diagnosis of coronary artery disease compared with SPECT. According to the results, it is suggested cardiologists use stress echocardiography instead of SPECT for the diagnosis of coronary artery disease. The result of the current study has significant concepts for decision-making in designing clinical guidelines for the diagnosis of coronary artery disease.

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“…Van der Wall et al conducted a cost analysis study on diagnostic modalities (including CTA, PET and SPECT) for diagnosis of suspected CAD. This study showed that SPECT is much more cheaper than CTA and PET over 2 years follow-up of suspected CAD patients [32]. However, it is reported that SPECT is signi cantly more expensive compared with stress echocardiography for CAD diagnosis [33].…”

Section: Discussionmentioning

confidence: 74%

A decision tree model for evaluating the cost effectiveness of Single-Photon Emission-Computed Tomography compared with stress echocardiography for diagnosis of coronary artery disease

Javan‐Noughabi¹,

Rezapour²,

Hajahmadi³

et al. 2020

Preprint

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Background Early diagnosis of coronary artery disease is very vital for success in treatment of this disease. However, the appropriate diagnostic modality for diagnosis of coronary artery disease is uncertain. Therefore, we conducted this study to compare the cost-effectiveness of Single-Photon Emission-Computed Tomography (SPECT) versus stress echocardiography for diagnosis of coronary artery disease in Iran.Methods A decision tree model was developed to compare the cost-effectiveness of SPECT versus stress echocardiography. This study was conducted in Tehran, capital of Iran, between April 1, 2017, and September 1, 2018. The cost analysis was conducted from a societal perspective and medical direct costs, nonmedical direct costs and indirect costs were estimated.. Effectiveness was defined as the accurate detection of coronary artery disease and invasive coronary angiography was used as a gold standard. The incremental cost-effectiveness ratio was defined as an additional cost per correct diagnosis.Results SPECT was associated with higher costs and lower effectiveness compared with stress echocardiography. Therefore stress echocardiography is dominant alternative compared to SPECT. The results also indicated that total cost per patient were $970.49 and $781.8 for SPECT and stress echocardiography, respectively. Also, the percent of true positive and true negative responses were %88 and %79 for SPECT and %90 and %92 for stress echocardiography.Conclusions The results of this study indicate that stress echocardiography is the cost-effective modality in the diagnosis of coronary artery disease compared with SPECT. According to the results, it is suggested cardiologists use stress echocardiography instead of SPECT for the diagnosis of coronary artery disease. The result of the current study has significant concepts for decision-making in designing clinical guidelines for the diagnosis of coronary artery disease.

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Cost analysis favours SPECT over PET and CTA for evaluation of coronary artery disease: the SPARC study

Cited by 9 publications

References 13 publications

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

The cost effectiveness of Single-Photon Emission-Computed Tomography compared with stress echocardiography for diagnosis of coronary artery disease

A decision tree model for evaluating the cost effectiveness of Single-Photon Emission-Computed Tomography compared with stress echocardiography for diagnosis of coronary artery disease

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