Cost analysis of ganciclovir and foscarnet in recipients of allogeneic hematopoietic cell transplant with cytomegalovirus viremia

Abstract

Background Ganciclovir (GCV) and foscarnet (FOS) are the most commonly used antivirals for preemptive treatment of cytomegalovirus (CMV) viremia in recipients of allogeneic hematopoietic cell transplantation (alloHCT). The current literature indicates similar efficacy between these agents. Thus, the primary consideration for choice of initial anti‐CMV treatment is the safety profile, time period after alloHCT, and concern of myelosuppression or renal dysfunction. Methods Herein, we retrospectively reviewed medical records of 124 alloHCT recipients who received GCV or FOS between April 27, 2014, and December 31, 2015, during the first year post‐transplant. Healthcare resource use included drug, hospitalization, home health, dialysis, and growth factor costs. Results Total duration of therapy was longer in the GCV group (37 days vs 28 days, P = .21) but hospitalization days were similar (9 days) in both groups. The total treatment cost was significantly lower in the GCV group ($38 100 vs $59 400, P < .05). Conclusion Preemptive anti‐CMV therapy is associated with major healthcare resource costs, which were greater in patients who required FOS than those who were treated with GCV.