“…Further, it has been suggested that mismatch in age, activity and body weight between donor and recipient may be crucial factors in the failure of allografts for ACL reconstruction [304]. In addition, the use of allografts is further limited by their higher overall surgical costs; approximately US$ 1,000 extra per clinical case [305,306]. For these reasons, the use of xenografts took off, with numerous products currently available [307,308].…”