Cost analysis of prophylaxis with antibiotics to prevent infected knee arthroplasty.

Abstract

A 72 year old woman presented with a five month history of pain of the mid-lumbar spine that had confined her to bed. Her other medical history was

Use of unicompartmental instead of tricompart-mental prostheses for unicompartmental arthrosis in the knee is a cost-effective alternative: 15,437 primary tricompartmental prostheses were compared with 10,624 primary medial or lateral unicompartmental prostheses

“…Murray et al (1997) reported the cost of aTKA revision to be 1.3 times that of a primary TKA and Lavemia et al (1995) found that the cost was 1.1 times that of a primary. However, catastrophes after knee arthroplasty, like infections or others causing arthrodesis, cost much more (Bengtson et al 1989, Hebert et al 1996. That these disasters are rarer after primary UKA than TKA further adds to the financial advantages of the UKA method.…”

The infected knee arthroplasty: A 6-year follow-up of 357 cases

“…Antibiotic prophylaxis is recommended until the wound is healed. This has also been proven to be economically efficient (Bengtson et al 1989b). Respiratory-tract, urinarytract, and other infections should be vigorously treated in patients with a knee arthroplasty (Bengtson et al 1987a).…”

PLGA and PHBV Microsphere Formulations and Solid-State Characterization: Possible Implications for Local Delivery of Fusidic Acid for the Treatment and Prevention of Orthopaedic Infections

“…But even with modern day sterilization, aseptic surgical procedures and ultra-clean operation rooms, orthopaedic surgeries can still be complicated by infections (1). Thus, the treatments (2)(3)(4)(5) and prevention (6)(7)(8)(9) of orthopaedic infections have utilized prolonged systemic antibiotic therapy. However, serious problems can arise from this approach, including a failure to produce therapeutic tissue concentrations of the antibiotics because of relatively low vascularity within necrotic bone and implant in prosthetic joint infections.…”