The study assessed the economic analysis of catfish production in Anambra West Metropolis, Anambra state, Nigeria. The sample size for the study comprised one hundred and twenty catfish farmers in Anambra West metropolis who were purposively selected. Data were collected using structured interview schedule by the researcher and other research assistants. Simple descriptive statistics like percentage, frequency, mean scores standard deviation and Net Farm Income were used for data analysis and result presentation. The study found that catfish production is a profitable business in the area with estimated total cost of ₦14,246,163 Net Farm Income of ₦20,000,000 and ROI of 2.47. Catfish producers in the area cited high feed costs, lack of capital and others as major constraints. The study suggests government engagement to manage and lower the import taxes levied on dealers who import foreign feeds and to develop local feed mills to increase feed production and nutritional content.