Cost-benefit analysis of prospective pharmacokinetic dosing of nortriptyline in depressed inpatients

Simmons, Shawn T.; Perry, Paul J.; Rickert, E.D.; Browne, J. C. McClure

doi:10.1016/0165-0327(85)90071-0

Cited by 36 publications

(20 citation statements)

References 4 publications

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“…Some studies calculated a benefit/cost ratio. For example, Simmons et al 75 indicated the relation between the input and output of services.…”

Section: Nature Of Economic Appraisalmentioning

confidence: 98%

“…The remaining studies specified the evaluation of only part of the costs, 79,96,118,123,130,151 estimated the costs 1,[64][65][66]112,140,152 or their method of evaluation was unclear. 64,65,67,69,71,75,99,100,109,119,127 About 9% of the studies reviewed explicitly mention the valuation of indirect costs. All the studies which actually gave a value to indirect costs used earnings.…”

Section: Measurement Of Costsmentioning

confidence: 99%

“…To measure information at a patient level one can also record the resources used 54,55,64,65,72,73,119,120,150 or time spent in treatment 74,75,78,96,119,123,124,132,133 by each patient. In some studies special forms or charts are used to register the services used.…”

Section: Measurement Of Costsmentioning

confidence: 99%

“…95 Discounting is not relevant if the study period is less than 1 year. 73,75,77,79,92,114,[119][120][121]123,[131][132][133]147,150,151,156 In our review, 22 studies 54,55,[58][59][60][61]66,[69][70][71]74,78,88,90,93,98,102,113,118,130,[134][135][136]141,145 discounted or indexed the results to a certain year, with discount rates usually varying between 2.5 and 6%. The most frequently used rates were 5 and 6%.…”

Section: Measurement Of Costsmentioning

confidence: 99%

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Economic Evaluation of Mental Health Care Interventions. A Review

Evers¹,

Wijk

Ament³

1997

Health Econ.

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Due to rising costs, the economic aspects of the mental health care sector are receiving increasing attention. This article scrutinizes 91 published studies in the field of mental health care, applying methodological criteria drawn from epidemiology and economics. The purpose of this study is to provide some insight into the quality of economic evaluation in the field of mental health care. The article shows that few good full economic evaluations studies have been undertaken in the domain of mental health care. One reason for this could be that the measurement of effectiveness in mental health care is complicated because of the known difficulties with the reliability of psychiatric diagnosis and the lack of consensus about the etiology and appropriate treatment for many psychiatric illnesses.

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“…Some studies calculated a benefit/cost ratio. For example, Simmons et al 75 indicated the relation between the input and output of services.…”

Section: Nature Of Economic Appraisalmentioning

confidence: 98%

Section: Measurement Of Costsmentioning

confidence: 99%

Section: Measurement Of Costsmentioning

confidence: 99%

Section: Measurement Of Costsmentioning

confidence: 99%

See 2 more Smart Citations

Economic Evaluation of Mental Health Care Interventions. A Review

Evers¹,

Wijk

Ament³

1997

Health Econ.

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“…TDM has been reported to increase not only efficacy and safety of TCAs, but also cost-effectiveness in the treatment of depression and is highly recommended for most tricyclic antidepressants. It reduces the risk of intoxication, and for many TCAs, a plasma concentration-clinical effectiveness relationship has been shown [5][6][7][8][9] . These older agents are limited by their greater risk of overdose, potential effects on cardiac conduction/arrythmias (TCAs), and substantial restrictions on diet and medications (MAOIs).…”

Section: Tricyclic Antidepressants and Monoamine Oxidase Inhibitorsmentioning

confidence: 99%

Therapeutic monitoring of psychoactive drugs - antidepressants: A review

Grundmann¹,

Kacířová²,

Urinovska³

2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Sources of Prediction Error When Using a Bayesian Method to Evaluate Nortriptyline Serum Concentrations

Kehoe¹,

Harralson²,

Jacisin³

et al. 1994

The Journal of Clinical Pharma

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A Bayesian method was used to evaluate nortriptyline (NTP) serum concentrations (Cps) and predict future Cps in two populations: five simulated groups (n = 20 each) with known clearance (CL) and volume of distribution (Vd), and an actual inpatient group (n = 20). The effects of weight, CL, Vd, and magnitude of Cps on absolute prediction error (APE) were evaluated. In simulated groups, Cps after two doses of NTP and for steady-state were calculated for normal, increased, and decreased Vd and CL. In the actual patient group, Cps were measured in the first few days after starting NTP administration and again during maintenance therapy. The first Cps were used in the Bayesian program to estimate CL and Vd to predict the second Cps. In the simulated group, PE and APE differed significantly between normal and decreased values of CL. A large Vd resulted in less of a change in PE or APE in these subjects, but when combined with low CL led to the largest errors. In the actual patient group, PE was -5.9 +/- 19.2 ng/mL and APE was 15.4 +/- 12.6 ng/mL. In these patients, only body weight was correlated with the percent APE (r = 0.607, P = 0.005). The Bayesian method performs well clinically, but increased Vd and decreased CL can lead to higher PE. Clinically, the only factor that predicted higher APE was obesity. This may reflect an effect on Vd, and in these patients, a high APE may occur.

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Cost-benefit analysis of prospective pharmacokinetic dosing of nortriptyline in depressed inpatients

Cited by 36 publications

References 4 publications

Economic Evaluation of Mental Health Care Interventions. A Review

Economic Evaluation of Mental Health Care Interventions. A Review

Therapeutic monitoring of psychoactive drugs - antidepressants: A review

Sources of Prediction Error When Using a Bayesian Method to Evaluate Nortriptyline Serum Concentrations

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