In the past, a patient went to the room where an ultrasound image diagnosis device was set, and then he or she was examined by a doctor. However, currently a doctor can go and examine the patient with a handheld ultrasound device who stays in a room. However, it was implemented with only fundamental functions, and can not meet the high performance required by the focusing algorithm of ultrasound beam which determines the quality of ultrasound image. In addition, low energy consumption was satisfied for the mobile ultrasound device. To satisfy these requirements, this paper proposes a high-performance and low-power single instruction, multiple data (SIMD) based multi-core processor that supports a representative beamforming algorithm out of several focusing methods of mobile ultrasound image signals. The proposed SIMD multi-core processor, which consists of 16 processing elements (PEs), satisfies the high-performance required by the beamforming algorithm by exploiting considerable data-level parallelism inherent in the echo image data of ultrasound. Experimental results showed that the proposed multi-core processor outperforms a commercial high-performance processor, TI DSP C6416, in terms of execution time (15.8 times better), energy efficiency (6.9 times better), and area efficiency (10 times better).