Cost-Effective Prophylaxis Against Venous Thromboembolism After Total Joint Arthroplasty: Warfarin Versus Aspirin

Is combined use of intravenous and intraarticular tranexamic acid superior to intravenous or intraarticular tranexamic acid alone in total knee arthroplasty? A meta-analysis of randomized controlled trials

“…This result was consistent with those studies that recommend the use of combined TXA on TXA [15, 19]. One highly observable time of DVT or PE was the postoperative of TKA within 30 days [30], and chemoprophylaxis [31, 32] has been recommended to those patients. All of our studies observed the DVT or PE at least 30 days, and chemical prophylaxis was given to all patients or to those high-risk patients.…”

Thromboembolism Prophylaxis in Hip Arthroplasty: Routine and High Risk Patients

“…As patient satisfaction continues to be a key determinant of quality of care and an important component of pay-for-performance metrics, use of a thromboprophylaxis protocol that is easy to administer with good compliance is essential. Furthermore, Mostafavi et al have performed a Markov cost-effectiveness analysis of aspirin versus warfarin following total joint arthroplasty and found aspirin to cost less and save more quality-adjusted life-years versus warfarin in all age groups [41]. Thus, the frequent monitoring required and potential increased risk of readmissions with the use of warfarin may become a greater concern as the number of total joint arthroplasties performed continues to grow.…”

Low-Dose Aspirin Is Adequate for Venous Thromboembolism Prevention Following Total Joint Arthroplasty: A Systematic Review

“…A disadvantage of warfarin is international normalized ratio testing and dose adjustments, which aspirin does not require. Additional laboratory testing, lower complication rates [9,17], and shorter length of hospitalization [3] suggest that aspirin is more cost-effective than warfarin [92,93]. Nam et al [17] found that patients treated with aspirin after THA also had a higher patient satisfaction at 2 weeks and 4-6 weeks postop compared to patients treated with warfarin.…”