Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer

Pérez‐Ortiz, José Manuel; Moya, Eva M; Cruz-Morcillo, Miguel A. de la; Rodríguez, Juan F.; Gracia, Ignacio; Redondo‐Calvo, Francisco Javier

doi:10.3390/ijms21082766

Cited by 18 publications

(27 citation statements)

References 40 publications

(44 reference statements)

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“…One of the OSCs present in garlic-alliin/s-allyl cysteine sulfoxide (SACS)-has been proposed as one of the potential drugs for colorectal cancer treatment [65]. Moreover, it was proposed that a combination of Allium extracts with 5-fluorouracil (5-FU) or oxaliplatin might be an effective treatment strategy for colon cancer patients [66]. The abovementioned strategy also seems to be promising due to the lower doses of chemotherapeutics needed to achieve similar clinical outcomes compared to chemotherapy alone.…”

Section: Colon Cancermentioning

confidence: 99%

The Potential Application of Allium Extracts in the Treatment of Gastrointestinal Cancers

Forma

Chilimoniuk

Januszewski

et al. 2021

Gastroenterology Insights

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Herbal medicine is currently widely practiced, since natural resources are reported to alleviate side effects during oncological treatment while modifying cancer cell responses at the same time. Allium vegetables and their constituents have recently been extensively investigated due to the numerous possible beneficial properties, establishing them as an additional treatment modality in different cancers. According to the epidemiological evidence, as well as many in vivo and in vitro studies, the abovementioned substances seem to be effective in the prevention and inhibition of the progression of carcinogenesis. Due to high concentrations of organosulfur compounds, which exhibit anticarcinogenic, antimicrobial, as well as anti-inflammatory properties, Allium constituents are believed to constitute a promising prevention and supportive therapy for oncological patients. Besides, it was demonstrated that a combination of Allium extracts with chemotherapy provided satisfactory clinical outcomes while at the same time being cost-effective. The aim of this review was to present and discuss currently investigated Allium extracts and their effects on several gastrointestinal cancers including gastric, colon, liver, esophageal, and pancreatic cancer.

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Section: Colon Cancermentioning

confidence: 99%

The Potential Application of Allium Extracts in the Treatment of Gastrointestinal Cancers

Forma

Chilimoniuk

Januszewski

et al. 2021

Gastroenterology Insights

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“…Various Allium extracts, aqueous or alcoholic, were tested individually as a single agent treatment or combined with cancer therapeutically drugs in several cancer lines like oral and lung [ 34 ], breast, cervical, colon and liver [ 35 , 36 , 37 , 38 , 39 ], leukemia [ 40 ], and squamous carcinoma [ 41 ]. Allium sativum extracts were also proven to have cytotoxic effects on multidrug-resistant human cancer cells by altering the mitochondrial permeability [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and In Vitro Effects of Allium fistulosum L. and Allium sativum L. Extracts on Human Normal and Tumor Cell Lines: A Comparative Study

et al. 2021

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Allium sativum L. (garlic bulbs) and Allium fistulosum L. (Welsh onion leaves) showed quantitative differences of identified compounds: allicin and alliin (380 µg/mL and 1410 µg/mL in garlic; 20 µg/mL and 145 µg/mL in Welsh onion), and the phenolic compounds (chlorogenic acid, p-coumaric acid, ferulic acid, gentisic acid, 4-hydroxybenzoic acid, kaempferol, isoquercitrin, quercitrin, quercetin, and rutin). The chemical composition determined the inhibitory activity of Allium extracts in a dose-dependent manner, on human normal cells (BJ-IC50 0.8841% garlic/0.2433% Welsh onion and HaCaT-IC50 1.086% garlic/0.6197% Welsh onion) and tumor cells (DLD-1-IC50 5.482%/2.124%; MDA-MB-231-IC50 6.375%/2.464%; MCF-7-IC50 6.131%/3.353%; and SK-MES-1-IC50 4.651%/5.819%). At high concentrations, the cytotoxic activity of each extract, on normal cells, was confirmed by: the 50% of the growth inhibition concentration (IC50) value, the cell death induced by necrosis, and biochemical determination of LDH, catalase, and Caspase-3. The four tumor cell lines treated with high concentrations (10%, 5%, 2.5%, and 1.25%) of garlic extract showed different sensibility, appreciated on the base of IC50 value for the most sensitive cell line (SK-MES-1), and the less sensitive (MDA-MB-231) cell line. The high concentrations of Welsh onion extract (5%, 2.5%, and 1.25%) induced pH changes in the culture medium and SK-MES-1 being the less sensitive cell line.

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“…These novel findings together suggest that patients detected more tumor numbers in surgery with high CA19-9 level may need to receive intensive preoperative chemotherapy to eliminate micrometastatic disease and, more importantly, to further identify aggressive disease and select appropriate candidates for surgery. Besides, some elements could inhibit colon cancer cells' proliferation and enhance the valid outcomes of chemotherapy [ 29 , 30 ]. Additionally, the benefit of surgery and high risk of recurrence should be carefully taken into consideration.…”

Section: Discussionmentioning

confidence: 99%

More Liver Metastases Detected Intraoperatively Indicates Worse Prognosis for Colorectal Liver Metastases Patients after Resection Combined with Microwave Ablation

Jiang

Zhang

Wang

et al. 2022

Journal of Oncology

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Background. Whether more tumor numbers detected in surgery compared to preoperative image affecting survival of colorectal liver metastases (CRLM) patients after hepatectomy combined with microwave ablation (MWA) remains unclear. Methods. From 2013 to 2018, 85 CRLM patients who underwent hepatectomy combined with MWA were retrospectively assessed. Compared to the tumor numbers in preoperative image, patients with equal intraoperative tumor numbers were defined as the equal number group ( n = 45 ); patients detected more tumor numbers in surgery were defined as the more number group ( n = 40 ). Clinicopathological factors and prognosis were compared between two groups. Results. Compared to the equal number group, the more number group was characterized by more lymphatic metastasis, synchronous metastasis of liver lesion, and tumor numbers over 5 (all P < 0.05 ). Median survival time was 46.7 months and 26.8 months in the equal and more number group. Significantly worse overall survival (OS) was found in more number group to the equal number group ( P = 0.027 ). In Cox analysis, more tumor number than image and high level of carbohydrate antigen 19-9 (CA19-9) were poor prognostic factors for OS. Conclusion. In patients receiving hepatectomy combined with MWA, detecting more liver metastases in surgery than preoperative image indicates poor long-term survival. These patients were characterized by more lymphatic metastasis, synchronous metastasis of liver lesion, and tumor numbers over 5. Intensive follow-up to detect early recurrence and potent postoperative therapy to improve survival may be justified in patients detected more tumor numbers in surgery with a high CA19-9 level.

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Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer

Cited by 18 publications

References 40 publications

The Potential Application of Allium Extracts in the Treatment of Gastrointestinal Cancers

The Potential Application of Allium Extracts in the Treatment of Gastrointestinal Cancers

Phytochemical Analysis and In Vitro Effects of Allium fistulosum L. and Allium sativum L. Extracts on Human Normal and Tumor Cell Lines: A Comparative Study

More Liver Metastases Detected Intraoperatively Indicates Worse Prognosis for Colorectal Liver Metastases Patients after Resection Combined with Microwave Ablation

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