Cost-Effective Wireless Microcontroller for Internet Connectivity of Open-Source Chemical Devices

Mercer, Conan; Leech, Dónal

doi:10.1021/acs.jchemed.8b00200

Cited by 16 publications

(12 citation statements)

References 38 publications

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“…Mercer et al . demonstrated that a cost-effective device could be produced using Internet of Things (IoT) connected microcontrollers that could log turbidity data 8 . While insight gained into the precipitation of NaCl from Na 2 S 2 O 3 and HCl was useful in the context of chemical education, insight gained from this type of measurement may also be of interest to scientists studying novel systems.…”

Section: Introductionmentioning

confidence: 99%

Use of open source monitoring hardware to improve the production of MOFs: using STA-16(Ni) as a case study

Massingberd‐Mundy

Poulston

Bennett

et al. 2020

Sci Rep

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Affordable and readily available microelectronics are becoming prevalent in teaching laboratories however these useful and economic tools are not used widely in either academia or industry. Herein we report how a metal organic framework (MOF) synthetic route can be optimized using an in situ monitoring apparatus designed in-house on open source hardware for under $100. We demonstrate that the MOF can be produced at atmospheric pressure, an improvement over previous reports, but also with a reduction in reaction time of 93%. This improvement in reaction time was predicted after a single experiment using the monitoring kit showing how efficiencies in the lab can be gained with very little experimental and monetary overhead while minimising the resources used.

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Section: Introductionmentioning

confidence: 99%

Use of open source monitoring hardware to improve the production of MOFs: using STA-16(Ni) as a case study

Massingberd‐Mundy

Poulston

Bennett

et al. 2020

Sci Rep

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“…In this communication we report on control of microfluidic flow and direction using inexpensive mass‐produced components: the Arduino Uno microcontroller, high torque servos, a commercial syringe pump and electronically commutated motors. Use of a microcontroller, instead of desktop or laptop, is a route towards miniaturisation, integration and automation of immunoassay protocols, identified as goals previously . The microcontroller can implement custom protocols and sequencing events in a rapid and simple manner using high‐level programming language C/C++.…”

Section: Figurementioning

confidence: 99%

Multiplexed Electrochemical Cancer Diagnostics With Automated Microfluidics

et al. 2018

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Microfluidic platforms can lead to miniaturisation, increased throughput and reduced reagent consumption, particularly when the processes are automated. Here, a programmable microcontroller is used for automation of a microfluidic platform configured to electrochemically determine the levels of 8 proteins simultaneously in complex liquid samples. The platform system is composed of a programmable Arduino microcontroller that controls inexpensive valve actuators, pump, magnetic stirrer and electronic display. The programmable microcontroller results in repeatable timing for each step in a complex assay protocol, such as sandwich immunoassays. Application of the platform is demonstrated using a multiplexed electrochemical immunoassay based on capture at the electrode surface of magnetic particles labelled with horseradish peroxidase and detection antibody. The multiplexed assay protocol is completed in less than 30 mins and results in detection of eight proteins associated with prostate cancer. The approach presented can be used to automate and simplify high‐throughput screening campaigns, such as detection of multiple biomarkers in patient samples.

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“…To this end, the iMED uses over the air updates (OTA) mechanism which allows the potentiostat to update itself based on data received while the normal firmware is running (for example, over WiFi). The device also sends all electrochemical data to an open-source cloud-based server for data post-processing [41]. This data is then visualised and accessible via any Internet connected device, such as a smart phone, tablet, laptop or wearable.…”

Section: Introductionmentioning

confidence: 99%

Glucose biosensor based on open-source wireless microfluidic potentiostat

Mercer

Bennett

Conghaile

et al. 2019

Sensors and Actuators B: Chemical

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Wireless potentiostats capable of cyclic voltammetry and amperometry that connect to the Internet are emerging as key attributes of future point-of-care devices. This work presents an "integrated microfluidic electrochemical detector" (iMED) three-electrode multi-potentiostat designed around operational amplifiers connected to a powerful WiFi-based microcontroller as a promising alternative to more expensive and complex strategies reported in the literature. The iMED is integrated with a microfluidic system developed to be controlled by the same microcontroller. The iMED is programmed wirelessly over a standard WiFi network and all electrochemical data is uploaded to an open-source cloud-based server. A wired desktop computer is not necessary for operation or program uploading. This method of integrated microfluidic automation is simple, uses common and inexpensive materials, and is compatible with commercial sample injectors. An integrated biosensor platform contains four screen-printed carbon arrays inside 4 separate microfluidic detection chambers with Pt counter and pseudo Ag/AgCl reference electrodes in situ. The iMED is benchmarked with K 3 [Fe(CN) 6 ] against a commercial potentiostat and then as a glucose biosensor using glucose-oxidising films of [Os(2,2′bipyridine) 2 (polyvinylimidazole) 10 Cl] prepared on screen-printed electrodes with multi walled carbon nanotubes, poly(ethylene glycol) diglycidyl ether and flavin adenine dinucleotidedependent glucose dehydrogenase. Potential application of this cost-effective wireless potentiostat approach to modern bioelectronics and point-of-care diagnosis is demonstrated by production of glucose oxidation currents, under pseudo-physiological conditions, using mediating films with lower redox potentials.

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Cost-Effective Wireless Microcontroller for Internet Connectivity of Open-Source Chemical Devices

Cited by 16 publications

References 38 publications

Use of open source monitoring hardware to improve the production of MOFs: using STA-16(Ni) as a case study

Use of open source monitoring hardware to improve the production of MOFs: using STA-16(Ni) as a case study

Multiplexed Electrochemical Cancer Diagnostics With Automated Microfluidics

Glucose biosensor based on open-source wireless microfluidic potentiostat

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