Cost-Effectiveness Analysis of Routine Mumps Immunization in Japan

Sugawara, Tamie; Ohkusa, Yasushi; Taya, Keiko; Oikawa, Kaoru; Haneda, Noriyuki; Kikuchi, Kiyoshi; Kato, Fumihide; Yamaguchi, Seiji; Yoshikawa, Tetuji; Nakano, Takashi; Ihara, Toshiaki; Tutumi, Hiroyuki; Asano, Yoshizo; Kamiya, Hitoshi; Okabe, Nobuhiko

doi:10.11150/kansenshogakuzasshi1970.81.555

Cited by 9 publications

(6 citation statements)

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“…municipalities with public subsidy of mumps vaccination as of May 27, 2016 (12). Calls for routine immunization with mumps vaccines are increasing (13)(14)(15). According to the Subcommittee on Basic Vaccination Policy of the Committee on Immunization and Vaccines of the Health Sciences Council, a prerequisite for instituting routine immunization with a mumps vaccine is the availability of a vaccine that is expected to be safer than previous vaccines, and it was proposed that a new MMR vaccine should be developed (16).…”

Section: Discussionmentioning

confidence: 99%

“…However, as of January 2018, no novel vaccine is expected to be approved. Meanwhile, among studies evaluating the safety (17,18), efficacy (13,17,19), and cost-effectiveness (14,15) of currently available monovalent mumps vaccine strains in Japan, the consensus is that the monovalent mumps vaccines are appropriate for routine immunization. Nevertheless, it is difficult to incorporate them in routine immunization which were previously excluded from use, without obtaining new safety data because of safety concerns in routine immunization.…”

Section: Discussionmentioning

confidence: 99%

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Effects of a Public Subsidy Program for Mumps Vaccine on Reducing the Disease Burden in Nagoya City, Japan

et al. 2019

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Nagoya City initiated a public subsidy program for mumps vaccination using either the Torii or Hoshino strains in August 2010. To determine the effects of the program, we used publicly available information from Nagoya City to investigate the changes in immunization rates and numbers of patients who developed post-immunization adverse reactions, including post-vaccinal aseptic meningitis, in the 7 years since its initiation. We also investigated the numbers of mumps patients reported by sentinel sites in a national database during this period. The immunization rate in one-year-old children increased from 24.3% before the program to 91.0% after 7 years. The mean numbers of reported mumps cases per sentinel site in one-year-old to preschool children-the age groups targeted by the program-were 12.9 in the 7 years before the program and 4.93 in the 7 years after initiation of the program, showing a significant decrease of 1/2.6 (p = 0.01). The number of vaccinations during the 6.5-year period was 140,316, with only one case of aseptic meningitis reported (0.7 cases/100,000 vaccinations). No other serious adverse reactions were observed. The present findings demonstrate that the public subsidy program in Nagoya City is an effective and safe measure against mumps in children.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of a Public Subsidy Program for Mumps Vaccine on Reducing the Disease Burden in Nagoya City, Japan

et al. 2019

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“…This study proposed additional evidence using a static model that Japan must start routine mumps vaccination urgently, considering the current enormous burden of the disease that we calculated in this study. There have been studies that showed the cost-effectiveness of mumps routine vaccination [ 11 12 25 26 ]. The cost-benefit ratio of independent inoculation from a social perspective in our study was 3.69.…”

Section: Discussionmentioning

confidence: 99%

“…Using surveillance data from 2000 to 2016, we calculated the number of annual average symptomatic mumps patients [ 2 5 ]. To estimate the burden of mumps and its related complications, we referred to each preceding study for reports of encephalitis, orchitis, oophoritis, hearing loss, other mumps-related hospitalizations, and outpatient cases [ 6 7 8 9 10 11 ]; however, for meningitis, we used the data from real mumps meningitis cases from our hospital because there were few data available about the burden of mumps meningitis in Japan. For example, Hoshi et al [ 12 ] used data on pneumococcal meningitis as an estimation of the burden of mumps meningitis in a previous study, but these data are not appropriate for the estimation of the burden of mumps meningitis because the clinical courses of mumps meningitis and pneumococcal meningitis are very different [ 6 ].…”

Section: Methodsmentioning

confidence: 99%

“…Regarding other mumps-related hospitalizations and outpatient cases, we used the study of Sugawara et al [ 11 ] with the results of 233,200 and 10,477 JPY as medical costs, respectively, and 9.5 days and 5.0 days×(adult women daily wage) as social cost, and 0.01 and 0.005 as QALYs loss per case. Five days was the mandatory absence period for all mumps cases.…”

Section: Methodsmentioning

confidence: 99%

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Static model simulation for routine mumps vaccination in Japan: with a result of mumps-related complications in a Japanese community hospital

Kitano

Onaka

Ishihara

et al. 2017

Clin Exp Vaccine Res

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PurposeMumps vaccine has not been included in the routine national immunization program in Japan, leading to low vaccine coverage rates and periodic epidemics approximately every 5 years. Our hospital (a secondary community hospital in Japan) experienced an increased number of mumps-related complications with a nationwide epidemic in 2016. Using previously reported data and mumps-related cases in our hospital, we estimated the cost-effectiveness of routine mumps vaccination in Japan with a static model using current epidemiologic data.Materials and MethodsWith a decision tree flowchart of mumps infection and adverse events, we estimated the burden of mumps-related complications in our hospital for 5 years, and calculated the current annual national burden. Finally, we compared the current burden and assumptive burden of the stable state after routine vaccination in Japan using a static model.ResultsThe cost-benefit ratios with sensitivity analysis were 3.69 (1.08-9.52) and 6.84 (1.51-23.73) in independent inoculation and simultaneous inoculation, respectively, from a social perspective in addition to an annual gain of 9,487 (3,227-14,659) quality adjusted life years.ConclusionWe contributed additional evidence in terms of cost-effectiveness that routine mumps vaccination should be introduced in Japan with simultaneous inoculation.

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Interdependency in vaccination policies among Japanese municipalities

Bessho

Ibuka

2018

Health Economics

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Economic theory predicts that vaccination policies at the local level can be negatively affected by the policies of neighboring regions because of free‐riding motives, whereas positive dependency may exist due to policy diffusions among localities. By using the unique variations in the provision of vaccination subsidies in Japan, we assess how vaccination policies in a local government are affected by the decisions of neighboring governments. We find that the provision of vaccination subsidies is positively correlated with the decisions of neighboring localities. Moreover, a correlation is found with neighboring municipalities within the same prefecture but not with those in surrounding prefectures, indicating that the correlations are likely to arise because of mimicking behavior among localities within a prefecture. Our results show that vaccination policies tend to be formed following neighboring municipalities and do not necessarily aim to optimize community health, thus questioning the autonomy of local government authorities regarding vaccination policies.

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Cost-Effectiveness Analysis of Routine Mumps Immunization in Japan

Cited by 9 publications

References 0 publications

Effects of a Public Subsidy Program for Mumps Vaccine on Reducing the Disease Burden in Nagoya City, Japan

Effects of a Public Subsidy Program for Mumps Vaccine on Reducing the Disease Burden in Nagoya City, Japan

Static model simulation for routine mumps vaccination in Japan: with a result of mumps-related complications in a Japanese community hospital

Interdependency in vaccination policies among Japanese municipalities

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