Cost-effectiveness and public health impact of typhoid conjugate vaccine introduction strategies in Bangladesh

Weyant, Christopher; Hooda, Yogesh; Munira, Sira Jam; Lo, Nathan C.; Ryckman, Theresa; Tanmoy, Arif M.; Kanon, Naito; Seidman, Jessica C.; Garrett, Denise; Saha, Samir K.; Goldhaber-Fiebert, Jeremy D.; Saha, Senjuti; Andrews, Jason R.

doi:10.1016/j.vaccine.2024.03.035

Cited by 2 publications

(1 citation statement)

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“…Using an ingredients-based approach, we will record costs for individual line items within categories including capital costs, materials, transportation, personnel, and operations. We will then adapt our previously published natural history and cost-effectiveness models of childhood helminth infections and enteric fever to project the health impacts and costeffectiveness of floor installation (Lo et al 2016(Lo et al , 2018Ryckman et al 2021;Weyant et al 2024). We will populate the model with outcome rates from the control and intervention arms of this trial, simulate age-specific risk over a ten-year period, and project DALYs for each health outcome for households with concrete floors and soil floors.…”

Section: Cost-effectiveness Analysismentioning

confidence: 99%

Effects of household concrete floors on maternal and child health – the CRADLE trial: a randomised controlled trial protocol

Rahman,

Jahan,

Hanif

et al. 2024

Preprint

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Introduction Early life soil-transmitted helminth infection and diarrhea are associated with growth faltering, anemia, impaired child development, and mortality. Exposure to fecally contaminated soil inside the home may be a key contributor to enteric infections, and a large fraction of rural homes in low-income countries have soil floors. The objective of this study is to measure the effect of installing concrete floors in homes with soil floors on child soil-transmitted helminth infection and other maternal and child health outcomes in rural Bangladesh. Methods and analysis The Cement-based flooRs AnD chiLd hEalth (CRADLE) trial is an individually randomised trial in Sirajganj and Tangail districts, Bangladesh. Households with a pregnant woman, a soil floor, walls that are not made of mud will be eligible, and no plan to relocate for 3 years. We will randomise 800 households to intervention or control (1:1) within geographic blocks of 10 households to account for strong geographic clustering of enteric infection. Laboratory staff and data analysts will be blinded; participants will be unblinded. We will install concrete floors when the birth cohort is in utero and measure outcomes at child ages 3, 6, 12, 18, and 24 months. The primary outcome is prevalence of any soil-transmitted helminth infection (Ascaris lumbricoides, Necator americanus, or Trichuris trichiura) detected by qPCR at 6, 12, 18, or 24 months follow-up in the birth cohort. Secondary outcomes include household floor and child hand contamination with E. coli, extended-spectrum beta-lactamase producing E. coli, and soil-transmitted helminth DNA; child diarrhea, growth, and cognitive development; and maternal stress and depression. Ethics and dissemination Study protocols have been approved by institutional review boards at Stanford University and the International Centre for Diarrheal Disease Research, Bangladesh (icddr,b). We will report findings on ClinicalTrials.gov, in peer-reviewed publications, and in stakeholder workshops in Bangladesh. Trial registration numberNCT05372068, pre-results

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Section: Cost-effectiveness Analysismentioning

confidence: 99%