Cost-effectiveness of hepatic resection versus percutaneous radiofrequency ablation for early hepatocellular carcinoma

Cucchetti, Alessandro; Piscaglia, Fabio; Cescon, Matteo; Colecchia, Antonio; Ercolani, Giorgio; Bolondi, Luigi; Pinna, Antonio Daniele

doi:10.1016/j.jhep.2013.04.009

Cited by 346 publications

(301 citation statements)

References 39 publications

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“…3 Indeed, according to the recent Barcelona Clinic Liver Cancer staging and treatment strategy guidelines for HCCs, RFA is favoured over surgical resection for very early stage HCCs (single nodule ,2 cm) in patients with Child-Pugh A liver cirrhosis. 4 Furthermore, a recent systematic review paper by Cucchetti et al 5 reported that for very early HCCs (single nodule ,2 cm) in Child-Pugh Class A patients, RFA provided similar life expectancy and quality-adjusted life expectancy at a lower cost than did surgical resection.…”

mentioning

confidence: 99%

“…[5][6][7][8][9][10][11][12] This is in large part owing to the limited ability of currently available RFA devices in creating a sufficiently large ablation zone encompassing HCCs 3-5 cm in diameter along with a safety margin. 7,11,13,14 Therefore, an ideal RFA system would provide the capability to create coagulations .5 cm in short-axis diameter within a reasonable time frame (,30 min) for the treatment of tumours .3 cm in diameter considering a sufficient safety margin (5-10 mm in thickness).…”

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confidence: 99%

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Switching bipolar hepatic radiofrequency ablation using internally cooled wet electrodes: comparison with consecutive monopolar and switching monopolar modes

Yoon

Lee²,

Woo

et al. 2015

BJR

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Objective: To evaluate whether switching bipolar radiofrequency ablation (SB-RFA) using three internally cooled wet (ICW) electrodes can induce coagulations .5 cm in porcine livers with better efficiency than consecutive monopolar (CM) or switching monopolar (SM) modes. The mean D min of coagulations was significantly larger in Group C than in Groups A and B (5.1 6 0.9, 3.9 6 1.2 and 4.4 6 1.0 cm, respectively, p 5 0.002) at a lower delivered RF energy level (76.8 6 14.3, 120.9 6 24.5 and 114.2 6 18.3 kJ, respectively, p , 0.001). Conclusion: SB-RFA using three ICW electrodes can create coagulations .5 cm in diameter with better efficiency than do SM-or CM-RFA. Advances in knowledge: SB-RFA can create large, regular ablation zones with better time-energy efficiency than do CM-or SM-RFA.

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mentioning

confidence: 99%

mentioning

confidence: 99%

Switching bipolar hepatic radiofrequency ablation using internally cooled wet electrodes: comparison with consecutive monopolar and switching monopolar modes

Yoon

Lee²,

Woo

et al. 2015

BJR

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“…In nodules less than 3 cm, surgical resection and ablative treatments are similar in terms of results obtained. For larger individual nodules (3-5 cm), surgical resection seems to favor a longer life expectancy and better cost-effectiveness than ablation; otherwise, in patients with 2-3 nodules less than 3 cm, life expectancy is similar for the two treatments although ablation showed a better cost-effectiveness [14].…”

Section: Early Disease Therapeutic Managementmentioning

confidence: 92%

Report from European Association for the Study of the Liver: HCC Summit, Geneva, Switzerland, 2–5 February 2017

et al. 2017

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The European Association for the Study of the Liver Hepatocellular Carcinoma (HCC) international meeting held in Geneva in February 2017 focused on the state of the art of HCC management, from diagnosis to treatment and the potential development of clinical research in this field. This report reviews some of the most interesting topics discussed at the meeting such as the role of hepatitis C viral infection treatment with direct-acting antivirals in enhancing HCC risk, current prognostic systems, early diagnosis techniques, curative therapies for early HCC and the systemic treatments for advanced disease with a look into future perspectives.

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“…The size limitation of RFA has been overcome with the use of expandable tipped or cool-tip electrodes, allowing effective ablation of areas ≥ 5 cm in diameter [48] . However, RCTs with a large sample size are needed before ablation therapy can be confirmed as an alternative to surgery for potentially resectable HCC.…”

Section: Failure Of Tacementioning

confidence: 99%

Recent advances in multidisciplinary management of hepatocellular carcinoma

Gomaa¹

2015

WJH

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Cost-effectiveness of hepatic resection versus percutaneous radiofrequency ablation for early hepatocellular carcinoma

Cited by 346 publications

References 39 publications

Switching bipolar hepatic radiofrequency ablation using internally cooled wet electrodes: comparison with consecutive monopolar and switching monopolar modes

Switching bipolar hepatic radiofrequency ablation using internally cooled wet electrodes: comparison with consecutive monopolar and switching monopolar modes

Report from European Association for the Study of the Liver: HCC Summit, Geneva, Switzerland, 2–5 February 2017

Recent advances in multidisciplinary management of hepatocellular carcinoma

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