Cost-effectiveness of lung cancer screening combined with nurse-led smoking cessation intervention: A population-based microsimulation study

Lung Cancer Screening: Implementation Challenges and Health Equity Considerations For the Western Pacific Region

“…A microsimulation model of a nurse-led cessation intervention made LCS more cost-effective in the Chinese setting. 61 Harnessing successful tobacco cessation initiatives outside LCS, such as the empowerment of community health workers to deliver interventions in LMICs, should be explored in the LCS setting. 62 Efforts to support smoking cessation are supported at a policy level as countries in the WPR make progress toward achieving the best practice measures outlined in the MPOWER framework, notably, the increase in the number of countries that offer cost-covered nicotine replacement therapy, and have increased taxation and education campaigns.…”

Cost-effectiveness of Lung Cancer Screening Combining with CVD and COPD Screening: A Microsimulation Study

“…Microsimulation model was used to simulate clinical outcomes, cost, and effectiveness of adults over 45 years under different screening strategies. In this study, the state transition models of LC, CVD and COPD were constructed respectively, and the LC model was detailed in our previous study 7 . The CVD model was modi ed according to the research of Huang et al 16 , which included four states: healthy, non-fatal CVD event, post CVD event, and fatal CVD event.…”

“…Parameters Smoking (starting and quitting probability), LC (incidence and death probability), and LDCT (sensitivity, speci city, screening compliance, over-diagnosis rate, excess relative risk of LC per screening) related transition probabilities are detailed in previous research. 7 Incidence probability of ASCVD. The validated China-PAR model was adopted in this study to predict ASCVD risk in China.…”

“…22 Calculation method adopted was the calculation process of non-LC death probability in previous studies. 7 For the population with non-fatal CVD events, the probability of fatal-CVD events occurring in the rst year was obtained by subtracting the non-CVD mortality (obtained from Yearbook 2012 21 ) from the death probability (obtained from Li et al 20 ). The standardized mortality ratio (SMR) on CVD background mortality 1 year after the occurrence of nonfatal CVD events was obtained from Chen et al 23 , and then the fatal-CVD probability was calculated.…”

“…LDCT can simultaneously detect CVD risk based on coronary artery calci cation (CAC) and earlier-stage COPD through emphysema or air trapping evaluation. 5 Our previous studies, 6,7 as well as many others, [8][9][10][11] have shown that LDCT screening of LC is cost-effective. However, it is still unclear of the effectiveness of screening for all three diseases at the same time.…”