Cost-effectiveness of pregabalin for the management of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia: A Canadian perspective

Tarride, Jean‐Éric; Gordon, Allan; Vera-Llonch, Montserrat; Dukes, Ellen; Rousseau, Catherine

doi:10.1016/j.clinthera.2006.11.017

Cited by 80 publications

(70 citation statements)

References 34 publications

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“…30 Pregabalin memiliki struktur yang mirip dengan gabapentin, namun pregabalin memiliki potensi analgesik yang lebih besar. 31 Sen dkk, dalam studinya menyatakan bahwa penggunaan gabapentin dengan dosis 1,2 gram dalam waktu 1 jam sebelum dilakukannya operasi histerektomi dapat mengurangi insiden nyeri kronis pasca operasi selama 6 bulan pasca operasi. 32 Pada studi Sen dkk, menyatakan insiden nyeri pasca operasi pada herniotomi berkurang dengan pemberian gabapentin 1,2 gram 1 jam sebelum operasi selama pemantauan 6 bulan.…”

Section: Gabapentinoidunclassified

Pencegahan nyeri kronis pasca operasi

Suseno¹

2017

MKA

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AbstrakNyeri kronis pasca operasi merupakan salah satu nyeri kronis yang paling sering terjadi. Nyeri kronis tersebut memberikan dampak negatif bagi kesehatan mental, kualitas hidup, dan perekonomian masyarakat. Penyebab dari nyeri kronis pasca operasi belum diketahui secara pasti, tetapi diduga bahwa perubahan plastisitas pada sistem saraf pusat berkontribusi dalam terjadinya nyeri kronis. Pencegahan terjadinya nyeri kronis pasca operasi dapat ditempuh dengan beberapa cara yang bertujuan untuk meminimalisir terjadinya sensitisasi pusat di sistem saraf pusat yang mengakibatkan nyeri kronis. Cara yang ditempuh dalam pencegahan nyeri kronis pasca operasi dengan mempertimbangkan faktor psikososial, pemilihan teknik operasi yang dapat meminimalisir kerusakan saraf perifer, pemilihan teknik anestesi, dan penggunaan preemptive analgesia. Dalam penulisan ini bertujuan untuk membahas mengenai patofisiologi nyeri kronis pasca operasi, cara yang ditempuh untuk mencegah terjadinya nyeri kronis pasca operasi, dan perlunya mempertimbangkan faktor psikososial selain intervensi farmakologis sebagai bagian dari pendekatan holistik dari penatalaksanaan perioperatif untuk mencegah nyeri kronis pasca operasi. Kata kunci: pencegahan; nyeri kronis; pasca operasi Abstract Chronic pain after surgery is one of the most common chronic pain. This type of pain has negative impact on mental health, quality of life, and the economy. The cause of chronic pain after surgery is not known for certain, but it is thought that the changes in plasticity in

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Section: Gabapentinoidunclassified

Pencegahan nyeri kronis pasca operasi

Suseno¹

2017

MKA

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“…The search identified 797 studies, 20 of which met the inclusion criteria. Of the 20 included studies, 14 presented original model structures 4,5,[16][17][18][19][20][21][22][23][24]27,29,30 , and six used existing model structures populated with data and assumptions that differed from those in the original study 3,25,26,[31][32][33] . Herein, where data and scope are compared, we refer to all 20 included studies, but where model type and structural elements are compared, we compare across the 14 original model structures only.…”

Section: Figure 1 Presents a Preferred Reporting Items For Systematicmentioning

confidence: 99%

“…The NRS is a universal scale, where the respondent selects a number from 0-10 that is best reflective of the pain they experience; 0 represents no pain and 10 represents the worst pain imaginable 40,41 . This scale was used in four of the 14 models 4,16,18,27 and in a further four studies 26,[31][32][33] . In one further model the pain data were informed by a daily pain score, but the scale used was not explicitly reported 19 .…”

Section: Approaches To Capture Pain Outcomesmentioning

confidence: 99%

“…The second most widely appraised therapy was gabapentin, used in five European studies 5,24,26,30,31 . Seven studies were conducted in North America 17,19,20,22,23,27,30 , where appraisal of pregabalin and gabapentin was common across cost-effectiveness analyses and over time 17,19,20,22,23,27,30 . Duloxetine has been appraised in two North American studies published since 2011 17,20 .…”

Section: Figure 1 Presents a Preferred Reporting Items For Systematicmentioning

confidence: 99%

“…These complexities include: patient and treatment heterogeneity; challenges in understanding how treatments affect health outcomes, in particular HRQoL; and understanding the HRQoL and cost implications of multiple, consecutive lines of often ineffective treatment. In 2013, the National Institute for Health and Care Excellence (NICE) in England and Wales reviewed previous economic analyses in neuropathic pain to inform guidance on pharmacological management of neuropathic pain 5 , and were critical of 'potentially serious limitations' in each of the 13 studies identified 4,[16][17][18][19][20][21][22][23][24][25][26][27] . However, the NICE reviewers were not specific in their criticism 5 .…”

Section: Introductionmentioning

confidence: 99%

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A systematic review of cost-effectiveness modeling of pharmaceutical therapies in neuropathic pain: variation in practice, key challenges, and recommendations for the future

Critchlow

Hirst

Akehurst

et al. 2016

Journal of Medical Economics

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Objectives: Complexities in the neuropathic-pain care pathway make the condition difficult to manage and difficult to capture in cost-effectiveness models. The aim of this study is to understand, through a systematic review of previous cost-effectiveness studies, some of the key strengths and limitations in data and modeling practices in neuropathic pain. Thus, the aim is to guide future research and practice to improve resource allocation decisions and encourage continued investment to find novel and effective treatments for patients with neuropathic pain. Methods: The search strategy was designed to identify peer-reviewed cost-effectiveness evaluations of non-surgical, pharmaceutical therapies for neuropathic pain published since January 2000, accessing five key databases. All identified publications were reviewed and screened according to pre-defined eligibility criteria. Data extraction was designed to reflect key data challenges and approaches to modeling in neuropathic pain and based on published guidelines. Results: The search strategy identified 20 cost-effectiveness analyses meeting the inclusion criteria, of which 14 had original model structures. Cost-effectiveness modeling in neuropathic pain is established and increasing across multiple jurisdictions; however, amongst these studies, there is substantial variation in modeling approach, and there are common limitations. Capturing the effect of treatments upon health outcomes, particularly health-related quality-of-life, is challenging, and the health effects of multiple lines of ineffective treatment, common for patients with neuropathic pain, have not been consistently or robustly modeled. Conclusions: To improve future economic modeling in neuropathic pain, further research is suggested into the effect of multiple lines of treatment and treatment failure upon patient outcomes and subsequent treatment effectiveness; the impact of treatment-emergent adverse events upon patient outcomes; and consistent and appropriate pain measures to inform models. The authors further encourage transparent reporting of inputs used to inform cost-effectiveness models, with robust, comprehensive and clear uncertainty analysis and, where feasible, open-source modeling is encouraged. ARTICLE HISTORY

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Pain Management

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Gavrin

2015

Thomas’ Hematopoietic Cell Transplantation

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Cost-effectiveness of pregabalin for the management of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia: A Canadian perspective

Cited by 80 publications

References 34 publications

Pencegahan nyeri kronis pasca operasi

Pencegahan nyeri kronis pasca operasi

A systematic review of cost-effectiveness modeling of pharmaceutical therapies in neuropathic pain: variation in practice, key challenges, and recommendations for the future

Pain Management

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