Cost-Effectiveness of Preoperative Topical Antibiotic Prophylaxis for Endophthalmitis Following Cataract Surgery

Felfeli, Tina; Miranda, Rafael N; Kaur, Jeeventh; Chan, Clara C.; Naimark, David

doi:10.1016/j.ajo.2022.11.008

Cited by 2 publications

(1 citation statement)

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“…The prophylactic use of antibiotics perioperatively to reduce endophthalmitis remains controversial and uncertain and varies geographically around the world. The AAO and the ESCRS have both reported that the use of preoperative topical antibiotics is unnecessary and not cost-effective [ 87 ]. Postoperatively, there were no differences in prophylaxis efficacy among various classes of topical antibiotics, including gatifloxacin, ofloxacin, and polymyxin/trimethoprim.…”

Section: Current Prophylactic Measures and Management Approachesmentioning

confidence: 99%

New Approaches to Overcoming Antimicrobial Resistance in Endophthalmitis

Garcia O’Farrill,

Abi Karam,

Villegas

et al. 2024

Pharmaceuticals

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Endophthalmitis is a rare but vision-threatening infection characterized by marked inflammation of intraocular fluids and tissues, uncommonly seen following surgery and intravitreal injection. Antimicrobials are used worldwide in the prophylaxis and treatment of bacterial and fungal infections of the eye and are standard treatment in the preoperative and postoperative care of surgical patients. However, antimicrobials are reported to be overprescribed in many parts of the world, which contributes to antimicrobial resistance (AMR). AMR complicates the prophylaxis and treatment of endophthalmitis. This article examines the prevalence and mechanisms of AMR in ocular microorganisms, emphasizing the importance of understanding AMR patterns for tailored treatments. It also explores prophylaxis and management strategies for endophthalmitis, with a discussion on the use of intracameral antibiotic administration. The use of prophylactic intracameral antibiotics during cataract surgery is common in many parts of the world but is still controversial in some locations, especially in the US. Finally, it highlights the role of stewardship in ophthalmology and its benefits in the treatment of endophthalmitis.

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Section: Current Prophylactic Measures and Management Approachesmentioning

confidence: 99%