2006
DOI: 10.1161/01.str.0000246611.21999.5d
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Cost-Effectiveness of Recombinant Activated Factor VII in the Treatment of Intracerebral Hemorrhage

Abstract: Background and Purpose-Intracerebral hemorrhage (ICH) is among the most costly and debilitating forms of stroke.Results from a recent Phase IIb clinical trial demonstrate that administration of recombinant activated factor VII (rFVIIa) reduces ICH mortality and improves functional outcome. In the current analysis, we examine the cost-effectiveness of early treatment with rFVIIa for ICH in the United States. Methods-A decision-analytic model was developed to estimate the lifetime costs and outcomes associated w… Show more

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Cited by 34 publications
(45 citation statements)
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“…Many analyses of the cost of adult stroke care have been conducted, and one aspect of these analyses, cost analysis, has been used to evaluate the efficacy of adult stroke treatments. [37][38][39][40] Analysis of pediatric stroke care could be used as one parameter to measure the effectiveness of treatment options. Recent calls for multicenter clinical trials of pediatric stroke 41,42 raise the possibility that opportunities will exist to examine cost data prospectively.…”
Section: Discussionmentioning
confidence: 99%
“…Many analyses of the cost of adult stroke care have been conducted, and one aspect of these analyses, cost analysis, has been used to evaluate the efficacy of adult stroke treatments. [37][38][39][40] Analysis of pediatric stroke care could be used as one parameter to measure the effectiveness of treatment options. Recent calls for multicenter clinical trials of pediatric stroke 41,42 raise the possibility that opportunities will exist to examine cost data prospectively.…”
Section: Discussionmentioning
confidence: 99%
“…The utility weight associated with mRS scores used here was obtained from a previous study 26 and has been used in several other cost-effectiveness analyses of stroke. 27,28 We measured overall cost-effectiveness using the incremental cost-effectiveness ratio (ICER), which is calculated by dividing the difference in average costs per patient between telestroke and usual care by the difference in average QALYs per patient between telestroke and usual care.…”
Section: Cost Inputs That Vary By Mrsmentioning
confidence: 99%
“…We used median utility for mild strokes (0.85) and an average for moderate and major strokes (0.27) as baseline utilities for independent and dependent health states. 19,21 For estimating annual mortality, we multiplied age-specific all-cause mortality rates from the 2006 United States Centers for Disease Control and Prevention life tables 22 by the relative risk of death for persons with independent (1.96) and dependent functional status (3.73) after neurological injury. 23 …”
Section: Utilitiesmentioning
confidence: 99%