Cost-effectiveness of selective internal radiation therapy with Y-90 resin microspheres for intermediate- and advanced-stage hepatocellular carcinoma in Brazil

Agirrezabal, Ion; Grillo, Luiz Sérgio Pereira; Nasser, Felipe; Brennan, Victoria K; Bugano, Diogo Diniz Gomes; Galastri, Francisco Leonardo; Azeredo-da-Silva, André Luís Ferreira; Shergill, Suki; Motta-Leal-Filho, Joaquim Maurício da

doi:10.1080/13696998.2023.2210475

Journal of Medical Economics

2023

DOI: 10.1080/13696998.2023.2210475

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Cost-effectiveness of selective internal radiation therapy with Y-90 resin microspheres for intermediate- and advanced-stage hepatocellular carcinoma in Brazil

Ion Agirrezabal

Luiz Sérgio Pereira Grillo

Felipe Nasser

et al.

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2024

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Cited by 2 publications

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Association of adverse events and quality of life in patients with unresectable hepatocellular carcinoma

Agirrezabal,

Pollock,

Carion

et al. 2024

Qual Life Res

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Purpose Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related deaths globally. Patients are often diagnosed with advanced disease, in which systemic and locoregional therapies are commonly used as first-line treatment. Such treatments can cause adverse events (AEs) that negatively affect quality of life (QoL), which is particularly undesirable where prognosis is poor. The aim of the present study was to evaluate the impact of common AEs on QoL in patients with HCC. Methods Data from the SARAH randomized controlled trial (RCT) were analyzed. Given the large number of distinct AEs that occurred in the trial, AEs were grouped as in the SARAH trial and prioritized using principal component analysis (PCA). Linear mixed-effects models were then applied with age, ECOG status, and AEs as predictors of the QoL change as measured with the EORTC Core Quality of Life Questionnaire (QLQ-C30). Results The PCA resulted in the selection of 28 AEs for inclusion in the linear mixed-effects models. Of the 28 AEs, diarrhea, decreased appetite, abdominal pain, and palmar-plantar erythrodysesthesia syndrome (hand-foot syndrome) were significant drivers of reductions in QoL as measured using the QLQ-C30 global health status scale. Diarrhea, abdominal pain, and hand-foot syndrome were also significant drivers of reduced QoL outcomes. Conclusion The present analysis showed that diarrhea, decreased appetite, abdominal pain, and palmar-plantar erythrodysesthesia were significantly associated with reduced QoL in patients with unresectable HCC. Reducing the incidence and/or severity of these AEs should therefore be a key focus when selecting the optimal treatments for these patients. Supplementary Information The online version contains supplementary material available at 10.1007/s11136-024-03779-w.

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Association of adverse events and quality of life in patients with unresectable hepatocellular carcinoma

Agirrezabal,

Pollock,

Carion

et al. 2024

Qual Life Res

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Efficacy of transarterial radioembolization using Y-90 resin microspheres versus atezolizumab-bevacizumab in unresectable hepatocellular carcinoma: A matching-adjusted indirect comparison

Agirrezabal,

Bouattour,

Pinato

et al. 2024

European Journal of Cancer

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Cost-effectiveness of selective internal radiation therapy with Y-90 resin microspheres for intermediate- and advanced-stage hepatocellular carcinoma in Brazil

Cited by 2 publications

References 70 publications

Association of adverse events and quality of life in patients with unresectable hepatocellular carcinoma

Association of adverse events and quality of life in patients with unresectable hepatocellular carcinoma

Efficacy of transarterial radioembolization using Y-90 resin microspheres versus atezolizumab-bevacizumab in unresectable hepatocellular carcinoma: A matching-adjusted indirect comparison

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