with MADM compared with DM controls without malignancy (P < 0.01), as expected, but NLRs were not significantly different in patients who died compared to those who remained alive (P = 0.11).Abundant research has shown NLR to be related to disease activity of inflammatory diseases, including DM, and to the prognosis of various cancers. 5 However, our results suggest that NLR does not have prognostic value in patients with MADM and is not able to predict the presence or development of malignancy in patients with DM. Thus, calculating an NLR in newly diagnosed patients with DM does not appear to be a useful exercise.The benefits of our study include a well-defined cohort not yet on immunomodulatory therapy, and comparison with matched DM controls without malignancy. Limitations include a relatively small cohort and variable timing of CBC and DM diagnosis.In summary, our results suggest calculating NLR is not useful to predict presence/development of underlying malignancy in patients with newly diagnosed DM, or for predicting prognosis of patients with MADM. However, NLR differences in patients with MADM who died compared with matched DM controls is notable, and the small number of patients who died (n = 4) suggest our results may be inconclusive concerning risk of death (Table 1). Further research aimed at identifying clinical risk factors of malignancy development and/or prognosis in patients with DM, including NLR, is needed. Figure 1 Flow chart of the teledermatology (TD) and face-to-face (F2F) pathways. 2WW, 2-week wait.
References