Cost-effectiveness of systemic therapies for metastatic pancreatic cancer.

Abstract

ConclusionsThe most cost-effective treatment for metastatic pancreatic cancer depends on the societal wtp threshold. If the societal wtp threshold were to be relatively high or if drug costs were to be substantially reduced, folfirinox might be cost-effective.

Impact of Country-Specific EQ-5D-3L Tariffs on the Economic Value of Systemic Therapies Used in the Treatment of Metastatic Pancreatic Cancer

“…Additional questions to ascertain respondent demographics were included in the survey, and the demographics of the oncologists who responded are presented in Table i here. More information on methods are provided in the original publication 32 .…”

“…We recently published a cost-effectiveness analysis for systemic therapies in pancreatic cancer from a Canadian public payer perspective 32 . In brief, a Markov analytic decision model was used to analyze a hypothetical cohort of patients with metastatic pancreatic cancer treated with one of four chemotherapy regimens.…”

“…Many Canadian cost-effectiveness analyses in cancer have been conducted using the utility scores derived from the U.K. tariffs [28][29][30][31] and, to a lesser extent, the U.S. tariffs 32 obtained from the EQ-5D-3L. The implications of this practice of using non-Canadian tariffs have not been determined, and the Canadian Agency for Drugs and Technologies in Health has not yet made an official recommendation on this topic.…”

“…As an example, we used an earlier analysis that aimed to assess the cost-effectiveness of various therapies for metastatic pancreatic cancer from a Canadian perspective. That study was originally performed using U.S.-based preference tariffs; in the present analysis, it was updated to use alternative country-specific tariffs 32 .…”

Untitled

“…[10] It has been considered the standard treatment for locally advanced or metastatic adenocarcinoma of the pancreas because has a wider spectrum of antitumor activity due to its different cellular pharmacology and mechanism of action. [11,12] The cytotoxic effects of Gem are exerted through incorporation into DNA resulting in inhibition of DNA synthesis and replication at several steps. [13,14] Folfirinox (Fol), is a combination of oxaliplatin, irinotecan, leucovorin, and fluorouracil, emerged as an effective nonGem containing regimen for metastatic pancreatic cancer.…”