Cost of colorectal cancer by treatment type from different health economic perspectives: A systematic review

Bhimani, Nazim; Wong, Geoffrey Ym; Molloy, Charles; Dieng, Mbathio; Hugh, Thomas J.

doi:10.1016/j.ejso.2022.06.023

Cited by 13 publications

(7 citation statements)

References 17 publications

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“…Nowadays, the cost of colorectal cancer treatment places a significant economic burden on populations and healthcare systems, such as surgical costs ranging from USD 1149 to 34,606, chemotherapy ranging from USD 1883 to 18,021, and radiotherapy ranging from USD 2037 to 5347 in 2018. Therefore, these costs actually impact healthcare budgets and guide policymakers in making informed decisions [ 9 ]. The current treatment for colorectal cancer depends on the type and stage of disease and includes surgery, chemotherapy, immunotherapy, and radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Imatinib Mesylate-Loaded Rosin/Cinnamon Oil-Based In Situ Forming Gel against Colorectal Cancer Cells

Khaing

Intaraphairot

Mahadlek

et al. 2022

Gels

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Localized delivery systems have been typically designed to enhance drug concentration at a target site and minimize systemic drug toxicity. A rosin/cinnamon oil (CO) in situ forming gel (ISG) was developed for the sustainable delivery of imatinib mesylate (IM) against colorectal cancer cells. CO has been claimed to express a potent anticancer effect against various cancer cells, as well as a synergistic effect with IM on colorectal cancer cells; however, poor aqueous solubility limits its application. The effect of rosin with the adding CO was assessed on physicochemical properties and in vitro drug release from developed IM-loaded rosin/CO-based ISG. Moreover, in vitro cytotoxicity tests were conducted against two colorectal cancer cells. All formulations exhibited Newtonian flow behavior with viscosity less than 266.9 cP with easier injectability. The adding of CO decreased the hardness and increased the adhesive force of the obtained rosin gel. The gel formation increased over time under microscopic observation. CO-added ISG had a particle-like gel appearance, and it promoted a higher release of IM over a period of 28 days. All tested ISG formulations revealed cytotoxicity against HCT-116 and HT-29 cell lines at different incubation times. Thus, CO-loaded rosin-based ISG can act as a potentially sustainable IM delivery system for chemotherapy against colorectal cancer cells.

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Section: Introductionmentioning

confidence: 99%

Imatinib Mesylate-Loaded Rosin/Cinnamon Oil-Based In Situ Forming Gel against Colorectal Cancer Cells

Khaing

Intaraphairot

Mahadlek

et al. 2022

Gels

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“…Compared with other cuisines, Muslim restaurants and Sichuan restaurants occupied larger market shares outside their places of origin, while Beijing restaurants and Taiwan restaurants took the smallest market shares in most districts (Figure 4). Among the 33 first-level administrative districts, Chinese restaurants in Macao covered the fewest kinds of cuisines (9), with Hong Kong coming in a close second (13). Specially, we also noted that most Muslim restaurants were located in Henan rather than Ningxia, Xinjiang, or Gansu, where more Muslims populated.…”

Section: B Spatial Distribution Of Tastesmentioning

confidence: 55%

“…It's worth mentioning that China is the biggest contributor to the global burden of CRC due to its large population [7]. Increasing CRC cases has been a tough challenge for China to overcome, hence, in-depth study on the characteristics of CRC in China becomes necessary [8,9].…”

Section: Introductionmentioning

confidence: 99%

Taste Mapping: Navigating the Spatiotemporal Link Between Diet and Colorectal Cancer

Luo,

Liu,

et al. 2024

IEEE Access

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Colorectal cancer is a major public health problem for its contribution to morbidity and mortality globally, and one of its major inducements is diet. Despite the achievements in the correlation studies about dietary habit and colorectal cancer, as an important component of dietary habit, taste preference has not received enough attention, its quantitative relationship with colorectal cancer has not been fully revealed. Using data from crowdsourced recipes, restaurant points of interest, and regional colorectal cancer mortality rates, this study quantitatively analysed the effects of different tastes on colorectal cancer, established a spatio-temporal link between taste and the disease, elucidating taste's role in the spatial distribution of colorectal cancer. According to the analysis, Chinese taste preference presents significant spatial heterogeneity, and Chinese cuisines most favour 'Spicy' which makes up the top two risk factors of colorectal cancer with 'Pungent'. Also, the interactions of Salty' with other tastes might increase colorectal cancer risk, the same goes for 'Oily'. The proposed quantitative analysis method based on crowdsourcing data can be applied to researches on other diseases, and the study can provide a new method and a new perspective for relevant studies.

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“…These cancers have high mortality rates and bring large consumption of treatment costs. [ 12 , 13 ] From the perspective of cost accounting results, China’s cancer treatment costs are mainly consumed by lung cancer, breast cancer, stomach cancer, liver cancer, etc., and the health output effect of resource input is poor. [ 14 ] Fourth, the institutional flow direction of costs reflects that the role of grassroots in China’s cancer prevention and treatment system is insufficient.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the composition and influencing factors of hospitalization expenses for 1517 patients with lung malignant tumors in Beijing

Zhao,

Tang

2024

Medicine

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This study aimed to analyze the composition of the total hospitalization expenses of patients with lung cancer in Beijing TongRen Hospital from January 2018 to December 2020 before and after the implementation of the “Beijing Medical Consumption Linkage Comprehensive Reform Implementation Plan” (hereinafter referred to as “Reform”). The SPSS 25.0 statistical software was used to perform descriptive statistics on the total hospitalization costs of selected 1517 patients with lung malignant tumors, and single factor and multivariate regression analysis were used to clarify the influencing factors of the patients’ total hospitalization costs. From 2018 to 2020, the total hospitalization costs of patients with lung malignant tumors increased year by year (P < .05), and the average length of hospital stay decreased year by year (P < .05). The total hospitalization expenses of patients with lung malignant tumors mainly include material expenses, surgical expenses, inspection expenses, inspection expenses and medicine expenses. After the implementation of the “Reform,” the proportion of medicine, inspection, nursing and other expenses in the total hospitalization expenses of patients with lung malignant tumors has been significantly reduced (P < .05), and the proportion of surgical expenses has been significantly increased (P < .05). The results of the univariate analysis showed that gender, age, length of stay in the hospital, surgery, and tumor location were the main factors affecting the total hospitalization expenses of patients (P < .05). The results of multivariate analysis showed that gender (female), age (<40 years old), length of stay (≥15 days), surgery (yes), and tumor location (right lung) are the main factors affecting the total hospitalization cost of patients with malignant tumors (P < .05). Under the premise of ensuring the efficacy of patients, the economic burden of patients is reduced by reducing the cost of materials, shortening the length of hospitalization, strengthening hospital management, and controlling the continuous growth of hospitalization costs.

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Cost of colorectal cancer by treatment type from different health economic perspectives: A systematic review

Cited by 13 publications

References 17 publications

Imatinib Mesylate-Loaded Rosin/Cinnamon Oil-Based In Situ Forming Gel against Colorectal Cancer Cells

Imatinib Mesylate-Loaded Rosin/Cinnamon Oil-Based In Situ Forming Gel against Colorectal Cancer Cells

Taste Mapping: Navigating the Spatiotemporal Link Between Diet and Colorectal Cancer

Analysis of the composition and influencing factors of hospitalization expenses for 1517 patients with lung malignant tumors in Beijing

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