Cost of Illness of Cystic Fibrosis in Germany

Abstract

The share of indirect costs as a percentage of total costs for CF was rather low in this study. However, the relevance of indirect costs is likely to increase in the future as the life expectancy of CF patients increases, which is likely to lead to a rising work disability rate and thus increase indirect costs. Moreover we found that infection with Pseudomonas aeruginosa increases costs substantially. Thus, a decrease of the prevalence of P. aeruginosa would lead to substantial savings for society.

Health economic modelling in Cystic Fibrosis: A systematic review

“…However, the economic impact of CF has also increased over the past three decades. Many costs of illness studies have been conducted in Europe and the United States (U.S) (17)(18)(19)(20)(21)(22)(23)(24)(25)(26).…”

“…Cost estimates for treatment based on data collected through regional CF centres, medical records, patient questionnaires, clinical trial and insurance claims or CF specific databases over the last three decades have demonstrated variable results. A wide range in costs, evaluated populations and different methodological approaches to calculate costs were also evident (17)(18)(19)(20)(21)(22)(23)(24)(25)(26). Where stated, medical drug treatment costs have contributed to anywhere between 12 to 85% of total costs.…”

“…Where stated, medical drug treatment costs have contributed to anywhere between 12 to 85% of total costs. Regression analyses demonstrates an increasing cost of care with disease severity (23). Which, over time, has been managed through an increasing range of drugs.…”

“…Within Europe, the cost of CF treatment per patient was, in 1996, €23,989 (20). In 2004, this increased to €41,468 per patient per year (23). However, considerable difference in per patient treatment costs have been demonstrated through estimates generated in other European countries.…”

Ion Channel Associated Diseases: Overview of Molecular Mechanisms

“…Cystic fibrosis (CF) is the most common fatal inherited disease among the white population 30 . CF is an autosomal recessive disorder involving multi organ dysfunction associated with defective epithelial chloride conductance 31–33 .…”