Cost of Intralesional Collagenase Clostridium Histiolyticum Therapy Versus Surgery for the Management of Peyronie's Disease: A Claims-Based Analysis (2009–2019)

Abstract

Background Collagenase Clostridium histolyticum (CCH), which was approved by the FDA for the treatment of Peyronie's disease (PD) in 2013, may obviate the need for surgery but its historically high cost must be considered when offering CCH vs surgical intervention to affected patients. Aim To compare trends of intralesional injections vs surgical treatment for PD and assess the contemporary cost of treatment with CCH vs surgical intervention. Methods We reviewed 2009–2019 MarketScan Commercial Claims data to identify all men 18 years and older with PD. CPT and HCPCS codes were used to identify PD treatments for each patient. Associated insurance claims in USD were summed for each treatment type. Outcomes Total and out-of-pocket costs, as well as frequencies, for treatments were calculated on a yearly basis and the Cochran-Armitage test was used to compare frequencies before and after FDA approval of CCH. Results Of 89,205 men diagnosed with PD, 21,605 (24.2%) underwent treatment; most required only intralesional injections, however 1,519 (7.0%) received only surgical therapy and 1,951 (9.0%) required medical and surgical therapy. Intralesional CCH use sharply increased after its FDA-approval in 2013 with a concomitant fall of intralesional verapamil use. The use of both surgical plication and plaque grafting decreased steadily from 2009 to 2019. The median cost per patient for all 3 treatments increased over the study time-period: $1,856 to $3,196 for plication, $2,233 to $3,631 for plaque grafting, and $6,940 to $8,895 per cycle for CCH. Out-of-pocket median patient contribution for plication, plaque grafting, and per cycle intralesional CCH injection were similar over the study period and never exceeded $300. Clinical Implications CCH is significantly more expensive than any surgical treatment option, however, the out-of-pocket patient contribution for surgery and CCH are similar. Strengths & Limitations This study incorporated all procedure costs and is the most contemporary, comprehensive, and accurate reflection of overall and out-of-pocket costs to patients for surgical and intralesional PD therapies. We anticipate these data to allow for a more complete discussion between patients and providers regarding their care. The use of a commercial claims database prohibited assessment of post-procedural costs and treatment outcomes. Conclusion CCH use has increased significantly since its FDA approval in 2013 with out-of-pocket patient contribution comparable to surgical therapy despite significantly higher total treatment costs.

Clinical and psychological effects post intralesional management with Collagenase Clostridium histolyticum in Peyronie's disease. Bibliographic review

“…(4) Es esencial mencionar que lamentablemente la viabilidad económica e implementación de la CCH es inversamente proporcional a sus beneficios, lo que ha resultado en tasas bajas de finalización del tratamiento y lo que dificulta su implementación en países cuyo sistema de salud no oferta esta opción terapéutica. (29) Ahora bien, aunque esto corresponde a una limitación, el uso intralesional de otros agentes menos efectivos como verapamilo o interferón A2b se pueden agregar a un protocolo que implemente simultáneamente la terapia mecánica e IPDE-5, convirtiéndose en una opción rentable, segura y efectiva a los pacientes que se rehúsan a la intervención quirúrgica y residen en países en vías de desarrollo.…”

Мodern Non-Invasive Methods for Treating Peyronie's Disease

“…Only two of the studies showed no change after subsequent therapy [39,44]. The average annual cost of verapamil is about US$60 according to 2019 US data [45].…”

“…There is also a significant price difference between the US and Europe. For example, an intralesional application in a US article is listed as US$300 [45]. Although intralesionally administered drugs are theoretically expected to be more effective than oral drugs due to the targeted direct effect in the penile plaque, published clinical studies show mixed results and this reflects the heterogeneous nature of PD with different manifestations.…”